Gene name:
Dynll1 (Dlc1;Dncl1;Dnclc1) ;
Protein name:
Dynein light chain 1, cytoplasmic ;
Alternative:
Dynein light chain LC8-type 1 ;8 kDa dynein light chain (DLC8) ;Protein inhibitor of neuronal nitric oxide synthase (PIN;mPIN) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1 (By similarity). Interacts with GCOM1.
Function:
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
Subcellular Location:
Cytoplasm
cytoskeleton
Nucleus
Mitochondrion
Protein Attributes:
50:
MCDRKAVIKN | ADMSEEMQQD | SVECATQALE | KYNIEKDIAA | HIKKEFDKKY |
89:
NPTWHCIVGR | NFGSYVTHET | KHFIYFYLGQ | VAILLFKSG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Rabbit
Human
Bovine
ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
Protein for Mouse Dynein light chain 1, cytoplasmic
Protein for Mouse Dynein light chain 1, cytoplasmic
Protein for Mouse Dynein light chain 1, cytoplasmic
Protein for Mouse Dynein light chain 1, cytoplasmic
Protein for Mouse Dynein light chain 1, cytoplasmic
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Intra-renal localization of mPIN (Protein Inhibitor of Nitric oxide synthase)."
Mount D.B.
Submitted (1997-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6J .
2.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Hippocampus .
tissue :
Kidney .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Mammary tumor .
4.
"Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection."
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Ashley M.D.
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J. Biol. Chem.286:19331-19339(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BCL2L11
5.
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J.
,
Chen Y.
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Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .