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Index > Protein center > Dynll1(Gene name) > Mouse
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  • Dynll1 (Gene name),
  • Dynein light chain 1, cytoplasmic (Protein name ),  DYL1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Dynll1(Dlc1;Dncl1;Dnclc1);
    Protein name:
    Dynein light chain 1, cytoplasmic;
    Alternative:
    Dynein light chain LC8-type 1;8 kDa dynein light chain(DLC8);Protein inhibitor of neuronal nitric oxide synthase(PIN;mPIN);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1 (By similarity). Interacts with GCOM1.
    Function:
    Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
    Subcellular Location:
    Cytoplasm cytoskeleton Nucleus Mitochondrion
    Protein Attributes:
    Sequence length:
    89
    Sequence:
    50:
    MCDRKAVIKN | ADMSEEMQQD | SVECATQALE | KYNIEKDIAA | HIKKEFDKKY | 
    89:
    NPTWHCIVGR | NFGSYVTHET | KHFIYFYLGQ | VAILLFKSG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    E13866r
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    E13866m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    E13866h
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    E13866b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    U13866b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    U13866h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    U13866r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    U13866m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    P13866Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    P13866Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Cat.:
    P13866Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Monoclonal Antibody for Mouse Dynein light chain 1, cytoplasmic
    Protein for Mouse Dynein light chain 1, cytoplasmic
    Protein for Mouse Dynein light chain 1, cytoplasmic
    Protein for Mouse Dynein light chain 1, cytoplasmic
    Protein for Mouse Dynein light chain 1, cytoplasmic
    Protein for Mouse Dynein light chain 1, cytoplasmic

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    References
    1. 1.
      "Intra-renal localization of mPIN (Protein Inhibitor of Nitric oxide synthase)."
      Mount D.B.
      Submitted (1997-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6J.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Hippocampus.
      tissue: Kidney.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    4. 4.
      "Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection."
      Thompson S. , Pearson A.N. , Ashley M.D. , Jessick V. , Murphy B.M. , Gafken P. , Henshall D.C. , Morris K.T. , Simon R.P. , Meller R.
      J. Biol. Chem.286:19331-19339(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL2L11
    5. 5.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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