Dynll1(Dncl1;Dnclc1;Pin);

Dynein light chain 1, cytoplasmic;

Dynein light chain LC8-type 1;8 kDa dynein light chain(DLC8);Protein inhibitor of neuronal nitric oxide synthase(PIN);

Rat (Rattus norvegicus). 

Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1 (By similarity). Interacts with rabies virus phosphoprotein. Interacts with GCOM1.

Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Cytoplasm cytoskeleton Nucleus Mitochondrion Associated with microtubules.

89

N/A

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Rn.35769

10116.ENSRNOP00000061342

P63170

PF01221

rno:58945

P63170