Gene name:
EIF2AK1 (PRO1362;HRI;KIAA1369) ;
Protein name:
Eukaryotic translation initiation factor 2-alpha kinase 1 ;
Alternative:
Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase ;Heme-controlled repressor (HCR) ;Hemin-sensitive initiation factor 2-alpha kinase ;Heme-regulated inhibitor ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Synthesized in an inactive form that binds to the N-terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation. Forms oligomers. Has been reported as a non-covalently bound homodimer, as well as a hexamer in the absence of hemin. Converted to an inactive disulfide linked homodimer in the presence of hemin.
Function:
Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MQGGNSGVRK | REEEGDGAGA | VAAPPAIDFP | AEGPDPEYDE | SDVPAEIQVL |
100:
KEPLQQPTFP | FAVANQLLLV | SLLEHLSHVH | EPNPLRSRQV | FKLLCQTFIK |
150:
MGLLSSFTCS | DEFSSLRLHH | NRAITHLMRS | AKERVRQDPC | EDISRIQKIR |
200:
SREVALEAQT | SRYLNEFEEL | AILGKGGYGR | VYKVRNKLDG | QYYAIKKILI |
250:
KGATKTVCMK | VLREVKVLAG | LQHPNIVGYH | TAWIEHVHVI | QPRADRAAIE |
300:
LPSLEVLSDQ | EEDREQCGVK | NDESSSSSII | FAEPTPEKEK | RFGESDTENQ |
350:
NNKSVKYTTN | LVIRESGELE | STLELQENGL | AGLSASSIVE | QQLPLRRNSH |
400:
LEESFTSTEE | SSEENVNFLG | QTEAQYHLML | HIQMQLCELS | LWDWIVERNK |
450:
RGREYVDESA | CPYVMANVAT | KIFQELVEGV | FYIHNMGIVH | RDLKPRNIFL |
500:
HGPDQQVKIG | DFGLACTDIL | QKNTDWTNRN | GKRTPTHTSR | VGTCLYASPE |
550:
QLEGSEYDAK | SDMYSLGVVL | LELFQPFGTE | MERAEVLTGL | RTGQLPESLR |
600:
KRCPVQAKYI | QHLTRRNSSQ | RPSAIQLLQS | ELFQNSGNVN | LTLQMKIIEQ |
630:
EKEIAELKKQ | LNLLSQDKGV | RDDGKDGGVG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rabbit
Rat
Mouse
ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 1
ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 1
ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 1
ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 1
CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 1
CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 1
CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 1
CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Polyclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Polyclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Polyclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Polyclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Monoclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Monoclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Monoclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Monoclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Protein for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Protein for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Protein for Human Eukaryotic translation initiation factor 2-alpha kinase 1
Protein for Human Eukaryotic translation initiation factor 2-alpha kinase 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Hair follicle dermal papilla .
2.
"Cloning and sequencing of a novel human cDNA homologous to rat hemin-sensitive initiation factor 2a kinase mRNA."
Tu Q.
,
Yu L.
,
Hu P.R.
,
Fu Q.
,
Cui Y.Y.
,
Zhao S.Y.
Submitted (1998-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
"Cloning of the human heme-regulated eukaryotic initiation factor 2-alpha kinase from TNF-alpha stimulated dermal microvascular endothelial cells."
Cannon G.
,
Naik S.M.
,
Boss J.M.
,
Caughman S.W.
Submitted (1999-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Skin .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
5.
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M.
,
Han Z.-G.
,
Song H.-D.
,
Peng Y.-D.
,
Huang Q.-H.
,
Ren S.-X.
,
Gu Y.-J.
,
Huang C.-H.
,
Li Y.-B.
,
Jiang C.-L.
,
Fu G.
,
Zhang Q.-H.
,
Gu B.-W.
,
Dai M.
,
Mao Y.-F.
,
Gao G.-F.
,
Rong R.
,
Ye M.
,
Zhou J.
,
Xu S.-H.
,
Gu J.
,
Shi J.-X.
,
Jin W.-R.
,
Zhang C.-K.
,
Wu T.-M.
,
Huang G.-Y.
,
Chen Z.
,
Chen M.-D.
,
Chen J.-L.
more...
Proc. Natl. Acad. Sci. U.S.A.97:9543-9548(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Hypothalamus .
6.
"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S.
,
Weil B.
,
Wellenreuther R.
,
Gassenhuber J.
,
Glassl S.
,
Ansorge W.
,
Boecher M.
,
Bloecker H.
,
Bauersachs S.
,
Blum H.
,
Lauber J.
,
Duesterhoeft A.
,
Beyer A.
,
Koehrer K.
,
Strack N.
,
Mewes H.-W.
,
Ottenwaelder B.
,
Obermaier B.
,
Tampe J.
,
Heubner D.
,
Wambutt R.
,
Korn B.
,
Klein M.
,
Poustka A.
more...
Genome Res.11:422-435(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Amygdala .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Bone marrow .
8.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-558
tissue :
Placenta .
tissue :
Tongue .
9.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
,
Rosenfelder H.
,
Duda A.
,
Schmidt C.P.
,
Ernst U.
,
Wellenreuther R.
,
Mehrle A.
,
Schuster C.
,
Bahr A.
,
Bloecker H.
,
Heubner D.
,
Hoerlein A.
,
Michel G.
,
Wedler H.
,
Koehrer K.
,
Ottenwaelder B.
,
Poustka A.
,
Wiemann S.
,
Schupp I.
more...
BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Amygdala .
10.
"Human chromosome 7: DNA sequence and biology."
Scherer S.W.
,
Cheung J.
,
MacDonald J.R.
,
Osborne L.R.
,
Nakabayashi K.
,
Herbrick J.-A.
,
Carson A.R.
,
Parker-Katiraee L.
,
Skaug J.
,
Khaja R.
,
Zhang J.
,
Hudek A.K.
,
Li M.
,
Haddad M.
,
Duggan G.E.
,
Fernandez B.A.
,
Kanematsu E.
,
Gentles S.
,
Christopoulos C.C.
,
Choufani S.
,
Kwasnicka D.
,
Zheng X.H.
,
Lai Z.
,
Nusskern D.R.
,
Zhang Q.
,
Gu Z.
,
Lu F.
,
Zeesman S.
,
Nowaczyk M.J.
,
Teshima I.
,
Chitayat D.
,
Shuman C.
,
Weksberg R.
,
Zackai E.H.
,
Grebe T.A.
,
Cox S.R.
,
Kirkpatrick S.J.
,
Rahman N.
,
Friedman J.M.
,
Heng H.H.Q.
,
Pelicci P.G.
,
Lo-Coco F.
,
Belloni E.
,
Shaffer L.G.
,
Pober B.
,
Morton C.C.
,
Gusella J.F.
,
Bruns G.A.P.
,
Korf B.R.
,
Quade B.J.
,
Ligon A.H.
,
Ferguson H.
,
Higgins A.W.
,
Leach N.T.
,
Herrick S.R.
,
Lemyre E.
,
Farra C.G.
,
Kim H.-G.
,
Summers A.M.
,
Gripp K.W.
,
Roberts W.
,
Szatmari P.
,
Winsor E.J.T.
,
Grzeschik K.-H.
,
Teebi A.
,
Minassian B.A.
,
Kere J.
,
Armengol L.
,
Pujana M.A.
,
Estivill X.
,
Wilson M.D.
,
Koop B.F.
,
Tosi S.
,
Moore G.E.
,
Boright A.P.
,
Zlotorynski E.
,
Kerem B.
,
Kroisel P.M.
,
Petek E.
,
Oscier D.G.
,
Mould S.J.
,
Doehner H.
,
Doehner K.
,
Rommens J.M.
,
Vincent J.B.
,
Venter J.C.
,
Li P.W.
,
Mural R.J.
,
Adams M.D.
,
Tsui L.-C.
more...
Science300:767-772(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Ovary .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 450-630;VARIANT ARG-558
tissue :
Fetal liver .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CDC37 AND THE HSP90 COMPLEX
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] THR-117; THR-132; LYS-134; SER-139; HIS-145; SER-202; LEU-292; HIS-319 AND ARG-558