E2f2 ELISA Kit for Mouse(Mus musculus) | EIAab.comE2f2 ELISA Kit for Mouse(Mus musculus)

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E2f2 (Gene name),

Transcription factor E2F2 (Protein name ), E2F2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

E2f2;

Protein name:

Transcription factor E2F2(E2F-2);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-2 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Binds EAPP.

Function:

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to RB1 protein, in a cell-cycle dependent manner.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

443

Sequence:

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