E2F4 ELISA Kit for Human(Homo sapiens) | EIAab.comE2F4 ELISA Kit for Human(Homo sapiens) | EIAab.com

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E2F4 (Gene name),

Transcription factor E2F4 (Protein name ), E2F4_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

E2F4;

Protein name:

Transcription factor E2F4(E2F-4);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. The E2F4/DP-1 dimer interacts preferentially with pocket protein RBL1, which inhibits the E2F transactivation domain. Lower affinity interaction has been found with retinoblastoma protein RB1. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Interacts with HCFC1. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

Function:

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-4 binds with high affinity to RBL1 and RBL2. In some instances, can also bind RB protein.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

413

Sequence:

50:

MAEAGPQAPP | PPGTPSRHEK | SLGLLTTKFV | SLLQEAKDGV | LDLKLAADTL |

100:

AVRQKRRIYD | ITNVLEGIGL | IEKKSKNSIQ | WKGVGPGCNT | REIADKLIEL |

150:

KAEIEELQQR | EQELDQHKVW | VQQSIRNVTE | DVQNSCLAYV | THEDICRCFA |

200:

GDTLLAIRAP | SGTSLEVPIP | EGLNGQKKYQ | IHLKSVSGPI | EVLLVNKEAW |

250:

SSPPVAVPVP | PPEDLLQSPS | AVSTPPPLPK | PALAQSQEAS | RPNSPQLTPT |

300:

AVPGSAEVQG | MAGPAAEITV | SGGPGTDSKD | SGELSSLPLG | PTTLDTRPLQ |

350:

SSALLDSSSS | SSSSSSSSSN | SNSSSSSGPN | PSTSFEPIKA | DPTGVLELPK |

400:

ELSEIFDPTR | ECMSSELLEE | LMSSEVFAPL | LRLSPPPGDH | DYIYNLDESE |

413:

GVCDLFDVPV | LNL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

MIM:

UniGene:

SMR:

STRING:

9606.ENSP00000368686

String:

KEGG:

Uniprot:

FOR

ELISA Kit for Human E2F-4

ELISA Kit for Human E2F-4

CLIA Kit for Human E2F-4

CLIA Kit for Human E2F-4

Polyclonal Antibody for Human E2F-4

Polyclonal Antibody for Human E2F-4

Monoclonal Antibody for Human E2F-4

Monoclonal Antibody for Human E2F-4

Protein for Human E2F-4

Protein for Human E2F-4

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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References

1.

"E2F-4, a new member of the E2F transcription factor family, interacts with p107."
Ginsberg D. , Vairo G. , Chittenden T. , Xiao Z.-X. , Xu G. , Wydner K.L. , Decaprio J.A. , Lawrence J.B. , Livingston D.M.
Genes Dev.8:2665-2679(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-319 INS;INTERACTION WITH RBL1;FUNCTION
tissue: Cervix carcinoma.
2.

"E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo."
Beijersbergen R.L. , Kerkhoven R.M. , Zhu L. , Carlee L. , Voorhoeve P.M. , Bernards R.
Genes Dev.8:2680-2690(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH RBL1;FUNCTION
tissue: Colon carcinoma.
3.

"E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle."
Sardet C. , Vidal M. , Cobrinik D. , Geng Y. , Onufryk C. , Chen A. , Weinberg R.A.
Proc. Natl. Acad. Sci. U.S.A.92:2403-2407(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Genomic structure and mutation screening of the E2F4 gene in human tumors."
Schwemmle S. , Pfeifer G.P.
Int. J. Cancer86:672-677(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

NIEHS SNPs program
Submitted (2002-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
10.

"The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130."
Williams C.D. , Linch D.C. , Soerensen T.S. , La Thangue N.B. , Thomas N.S.B.
Br. J. Haematol.96:688-696(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBL2
11.

"E2F transcriptional activation requires TRRAP and GCN5 cofactors."
Lang S.E. , McMahon S.B. , Cole M.D. , Hearing P.
J. Biol. Chem.276:32627-32634(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRRAP
12.

"HCF-1 functions as a coactivator for the zinc finger protein Krox20."
Luciano R.L. , Wilson A.C.
J. Biol. Chem.278:51116-51124(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCFC1
13.

"Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release."
Rubin S.M. , Gall A.-L. , Zheng N. , Pavletich N.P.
Cell123:1093-1106(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WITH RB1; RBL1; TFDP1 AND TFDP2
14.

"LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."
Schmit F. , Korenjak M. , Mannefeld M. , Schmitt K. , Franke C. , von Eyss B. , Gagrica S. , Haenel F. , Brehm A. , Gaubatz S.
Cell Cycle6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE DREAM COMPLEX
15.

"Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."
Litovchick L. , Sadasivam S. , Florens L. , Zhu X. , Swanson S.K. , Velmurugan S. , Chen R. , Washburn M.P. , Liu X.S. , DeCaprio J.A.
Mol. Cell26:539-551(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE DREAM COMPLEX
16.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
17.

"Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence."
Martin N. , Benhamed M. , Nacerddine K. , Demarque M.D. , van Lohuizen M. , Dejean A. , Bischof O.
EMBO J.31:95-109(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PML
18.

"Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP."
Zheng N. , Fraenkel E. , Pabo C.O. , Pavletich N.P.
Genes Dev.13:666-674(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 11-86
19.

"Various AGC repeat numbers in the coding region of the human transcription factor gene E2F-4."
Zhong X. , Hemmi H. , Koike J. , Tsujita K. , Shimatake H.
Hum. Mutat.15:296-297(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM

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