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Index > Protein center > E2F7(Gene name) > Human
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  • E2F7 (Gene name),
  • Transcription factor E2F7 (Protein name ),  E2F7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    E2F7;
    Protein name:
    Transcription factor E2F7(E2F-7);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA binding.
    Function:
    Along with E2F8, inhibitor of E2F-dependent transcription that is important for the control of the E2F1-TP53 apoptotic pathway. Directly represses E2F1 transcription (By similarity). Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    911
    Sequence:
    50:
    MEVNCLTLKD | LISPRQPRLD | FAVEDGENAQ | KENIFVDRSR | MAPKTPIKNE | 
    100:
    PIDLSKQKKF | TPERNPITPV | KFVDRQQAEP | WTPTANLKML | ISAASPDIRD | 
    150:
    REKKKGLFRP | IENKDDAFTD | SLQLDVVGDS | AVDEFEKQRP | SRKQKSLGLL | 
    200:
    CQKFLARYPS | YPLSTEKTTI | SLDEVAVSLG | VERRRIYDIV | NVLESLHLVS | 
    250:
    RVAKNQYGWH | GRHSLPKTLR | NLQRLGEEQK | YEEQMAYLQQ | KELDLIDYKF | 
    300:
    GERKKDGDPD | SQEQQLLDFS | EPDCPSSSAN | SRKDKSLRIM | SQKFVMLFLV | 
    350:
    SKTKIVTLDV | AAKILIEESQ | DAPDHSKFKT | KVRRLYDIAN | VLTSLALIKK | 
    400:
    VHVTEERGRK | PAFKWIGPVD | FSSSDEELVD | VSASVLPELK | RETYGQIQVC | 
    450:
    AKQKLARHGS | FNTVQASERI | QRKVNSEPSS | PYREEQGSGG | YSLEIGSLAA | 
    500:
    VYRQKIEDNS | QGKAFASKRV | VPPSSSLDPV | APFPVLSVDP | EYCVNPLAHP | 
    550:
    VFSVAQTDLQ | AFSMQNGLNG | QVDVSLASAA | SAVESLKPAL | LAGQPLVYVP | 
    600:
    SASLFMLYGS | LQEGPASGSG | SERDDRSSEA | PATVELSSAP | SAQKRLCEER | 
    650:
    KPQEEDEPAT | KRQSREYEDG | PLSLVMPKKP | SDSTDLASPK | TMGNRASIPL | 
    700:
    KDIHVNGQLP | AAEEISGKAT | ANSLVSSEWG | NPSRNTDVEK | PSKENESTKE | 
    750:
    PSLLQYLCVQ | SPAGLNGFNV | LLSGSQTPPT | VGPSSGQLPS | FSVPCMVLPS | 
    800:
    PPLGPFPVLY | SPAMPGPVSS | TLGALPNTGP | VNFSLPGLGS | IAQLLVGPTA | 
    850:
    VVNPKSSTLP | SADPQLQSQP | SLNLSPVMSR | SHSVVQQPES | PVYVGHPVSV | 
    900:
    VKLHQSPVPV | TPKSIQRTHR | ETFFKTPGSL | GDPVLKRRER | NQSRNTSSAQ | 
    911:
    RRLEIPSGGA | D
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human E2F-7
    ELISA Kit for Human E2F-7
    ELISA Kit for Human E2F-7
    ELISA Kit for Human E2F-7
    CLIA Kit for Human E2F-7
    CLIA Kit for Human E2F-7
    CLIA Kit for Human E2F-7
    CLIA Kit for Human E2F-7
    Polyclonal Antibody for Human E2F-7
    Polyclonal Antibody for Human E2F-7
    Polyclonal Antibody for Human E2F-7
    Polyclonal Antibody for Human E2F-7
    Monoclonal Antibody for Human E2F-7
    Monoclonal Antibody for Human E2F-7
    Monoclonal Antibody for Human E2F-7
    Monoclonal Antibody for Human E2F-7
    Protein for Human E2F-7
    Protein for Human E2F-7
    Protein for Human E2F-7
    Protein for Human E2F-7

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 595-911 (ISOFORM 2);VARIANT LEU-72
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-911 (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 504-911 (ISOFORM 3);VARIANT LEU-72
      tissue: Testis.
    4. 4.
      "E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes."
      Di Stefano L. , Jensen M.R. , Helin K.
      EMBO J.22:6289-6298(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;FUNCTION;SELF-ASSOCIATION;MUTAGENESIS OF 147-LEU-GLY-148
    5. 5.
      "E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains."
      Logan N. , Delavaine L. , Graham A. , Reilly C. , Wilson J. , Brummelkamp T.R. , Hijmans E.M. , Bernards R. , La Thangue N.B.
      Oncogene23:5138-5150(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SELF-ASSOCIATION;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-185 AND ARG-334
    6. 6.
      "Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development."
      Li J. , Ran C. , Li E. , Gordon F. , Comstock G. , Siddiqui H. , Cleghorn W. , Chen H.-Z. , Kornacker K. , Liu C.-G. , Pandit S.K. , Khanizadeh M. , Weinstein M. , Leone G. , de Bruin A.
      Dev. Cell14:62-75(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;SUBUNIT;MUTAGENESIS OF ARG-185 AND ARG-334
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1."
      Weijts B.G. , Bakker W.J. , Cornelissen P.W. , Liang K.H. , Schaftenaar F.H. , Westendorp B. , de Wolf C.A. , Paciejewska M. , Scheele C.L. , Kent L. , Leone G. , Schulte-Merker S. , de Bruin A.
      EMBO J.31:3871-3884(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HIF1A
    11. 11.
      "E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation."
      Endo-Munoz L. , Dahler A. , Teakle N. , Rickwood D. , Hazar-Rethinam M. , Abdul-Jabbar I. , Sommerville S. , Dickinson I. , Kaur P. , Paquet-Fifield S. , Saunders N.
      Cancer Res.69:1800-1808(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Loss of E2F7 expression is an early event in squamous differentiation and causes derepression of the key differentiation activator Sp1."
      Hazar-Rethinam M. , Cameron S.R. , Dahler A.L. , Endo-Munoz L.B. , Smith L. , Rickwood D. , Saunders N.A.
      J. Invest. Dermatol.131:1077-1084(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression."
      Carvajal L.A. , Hamard P.J. , Tonnessen C. , Manfredi J.J.
      Genes Dev.26:1533-1545(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    14. 14.
      "The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence."
      Aksoy O. , Chicas A. , Zeng T. , Zhao Z. , McCurrach M. , Wang X. , Lowe S.W.
      Genes Dev.26:1546-1557(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
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