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Index > Protein center > E2f7(Gene name) > Mouse
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  • E2f7 (Gene name),
  • Transcription factor E2F7 (Protein name ),  E2F7_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    E2f7;
    Protein name:
    Transcription factor E2F7(E2F-7);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA binding.
    Function:
    Along with E2F8, inhibitor of E2F-dependent transcription that is important for embryonic development and for the control of the E2f1-Tp53 apoptotic pathway. Directly represses E2F1 transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    904
    Sequence:
    50:
    MEVNCLTLKD | LISPRQTRLD | FAIEDAENAQ | KENIFVDRSR | MTPKTPMKNE | 
    100:
    PIDLSKQRIF | TPDRNPITPV | KPVDRQPQVE | PWTPTANLKM | LISAASPDIR | 
    150:
    DREKKKELFR | PIENKEDAFV | NSLQLDVAGD | GAVDEYEKQR | PSRKQKSLGL | 
    200:
    LCQKFLARYP | SYPLSTEKTT | ISLDEVAVSL | GVERRRIYDI | VNVLESLHLV | 
    250:
    SRVAKNQYGW | HGRHSLPKTL | RTLQRLGEEQ | KYEEQMACLQ | QKELDLMGYR | 
    300:
    FGERRKDGSP | DPRDPHLLDF | SEADYPSSSA | NSRKDKSLRI | MSQKFVMLFL | 
    350:
    VSKTKIVTLD | VAAKILIEES | QDTPDHSKFK | TKVRRLYDIA | NVLTSLALIK | 
    400:
    KVHVTEERGR | KPAFKWIGPV | DFSSIDEELL | DVSASILPEL | KKEAYGQIRV | 
    450:
    CAKERLVRYG | SFNTVHTSEK | IQRKVSSEPS | SPQGERQGSA | YSLEIGSLAA | 
    500:
    IYRQKVEDNS | QEEAFVSNTA | VPPASILDPA | LSMDSEYCVK | PLAQPVFSVA | 
    550:
    QTDLPAFSAQ | NGPSGQVGVP | VPSAASDTEN | LKPALLAGQP | LVYVPSTQLF | 
    600:
    MLYGSVQEGL | SPESRSEEDG | GGSDVPADLS | VTPSAQKRLC | EERDPQEEED | 
    650:
    EPAMKRQSQE | FEDSPLSLVM | PKKPSSSTDL | ACPVTMGNGS | SPPLEDACVK | 
    700:
    GQLPAAEEVT | GKAAPNCYVA | SECGNPARNP | DTEKPSNENE | ITKDPSLMQY | 
    750:
    LYVQSPAGLN | GFNMVLPGTQ | TPHTVAPSPA | QLPSFGVPCM | FLQSPGLGPF | 
    800:
    PVLYSPAIPG | PISSAPGTHP | NPGPMNFGLS | TLASASHLLI | SPAAMVNPKP | 
    850:
    STLPCTDPQL | RCQPSLNLNP | VMPGSHGVIH | PESPCYVRHP | VSMVKAEQSP | 
    900:
    APATPKSIQR | RHRETFFKTP | GSLGDPVFRR | KERNQSRNTS | SAQRRLEISS | 
    904:
    SGPD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E2F-7
    ELISA Kit for Mouse E2F-7
    ELISA Kit for Mouse E2F-7
    ELISA Kit for Mouse E2F-7
    CLIA Kit for Mouse E2F-7
    CLIA Kit for Mouse E2F-7
    CLIA Kit for Mouse E2F-7
    CLIA Kit for Mouse E2F-7
    Polyclonal Antibody for Mouse E2F-7
    Polyclonal Antibody for Mouse E2F-7
    Polyclonal Antibody for Mouse E2F-7
    Polyclonal Antibody for Mouse E2F-7
    Monoclonal Antibody for Mouse E2F-7
    Monoclonal Antibody for Mouse E2F-7
    Monoclonal Antibody for Mouse E2F-7
    Monoclonal Antibody for Mouse E2F-7
    Protein for Mouse E2F-7
    Protein for Mouse E2F-7
    Protein for Mouse E2F-7
    Protein for Mouse E2F-7

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation."
      de Bruin A. , Maiti B. , Jakoi L. , Timmers C. , Buerki R. , Leone G.
      J. Biol. Chem.278:42041-42049(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      strain: C57BL/6J.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Forelimb.
      tissue: Spleen.
      tissue: Thymus.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Embryo.
    5. 5.
      "Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development."
      Li J. , Ran C. , Li E. , Gordon F. , Comstock G. , Siddiqui H. , Cleghorn W. , Chen H.-Z. , Kornacker K. , Liu C.-G. , Pandit S.K. , Khanizadeh M. , Weinstein M. , Leone G. , de Bruin A.
      Dev. Cell14:62-75(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    6. 6.
      "E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1."
      Weijts B.G. , Bakker W.J. , Cornelissen P.W. , Liang K.H. , Schaftenaar F.H. , Westendorp B. , de Wolf C.A. , Paciejewska M. , Scheele C.L. , Kent L. , Leone G. , Schulte-Merker S. , de Bruin A.
      EMBO J.31:3871-3884(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    8. 8.
      "The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence."
      Aksoy O. , Chicas A. , Zeng T. , Zhao Z. , McCurrach M. , Wang X. , Lowe S.W.
      Genes Dev.26:1546-1557(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    11. 11.
      "E2F7 represses a network of oscillating cell cycle genes to control S-phase progression."
      Westendorp B. , Mokry M. , Groot Koerkamp M.J. , Holstege F.C. , Cuppen E. , de Bruin A.
      Nucleic Acids Res.40:3511-3523(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;DEVELOPMENTAL STAGE
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