E2F8 ELISA Kit for Bovine(Bos taurus) | EIAab.comE2F8 ELISA Kit for Bovine(Bos taurus) | EIAab.com

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E2F8 (Gene name),

Transcription factor E2F8 (Protein name ), E2F8_BOVIN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

E2F8;

Protein name:

Transcription factor E2F8(E2F-8);

Alternative:

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA-binding. Interacts with HIF1A.

Function:

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

866

Sequence:

50:

MENEKENLFF | EPHKRGLMKT | PLKESTAANI | VLADIQPDFG | PLTTPTKPKE |

100:

ISQGEPWTPT | ANLKMLISAV | SPEIRNRDQK | RGLFDNRNGL | SDVKDCLHEH |

150:

FSGDEYEKSQ | PSRKEKSLGL | LCHKFLARYP | NYPNPAVNND | ICLDEVAEEL |

200:

NVERRRIYDI | VNVLESLHMV | SRLAKNRYTW | HGRHNLNQIL | ETLKSVGEEN |

250:

KYAEQIMMIK | KKEYEQEFEV | SKSYNTEDPI | IKSNTGQNGH | PDMCCAERPG |

300:

VELRAASVNS | RKDKSLKVMS | QKFVTLFLVS | TPQIVSLEIA | AKILTWEDHV |

350:

EDLDRSKFKT | KIRRLYDIAN | VLSSLDLIKK | VHVTEERGRK | PAFKWTGPEI |

400:

SPNPSGLSPV | LPCAASDLEA | RQSSKENCAK | NLFSTRGKPN | FTRHPSLIKL |

450:

VKSIESDRRK | INSAPSSPIK | THKAESTQNS | VPFRSKMAQL | AAICKMQLEE |

500:

QSSEPRKNVT | VQLAGSGHCK | SVAPLDTPAN | AEPEMMAPSL | IQPLGVVPLL |

550:

PSPLSPAVPV | ILPQTPSGTS | YAIYLQPAQA | QTITPPPGLS | PTVCPTTSSN |

600:

AMISEDSTDA | TGENADSDAP | KSSVSTRPGS | LLPGPERQGA | KNREREPARE |

650:

KGSKRASMLE | DSGSKKKFKE | DQKAPENVST | TLFPSGYLIP | LTQCSTLGAE |

700:

SILSSNENSG | TLSPNHSIYS | SPIAGVIPVT | SSELTAVNFP | SFQVTPLKLM |

750:

VSPTSMAAVP | VGNSPALSSS | HPLPIQNPSS | AIVNFTLQHL | GLISPGVQVS |

800:

TSPGPGTIAV | SPRIEAVSVT | PENAGAEQGR | ATKCDASILS | QNQTNGQSFA |

850:

GTGAQQPVPV | TPKGSQPVAE | SFFRTPGGPT | KPTGSPCTDF | DGANYTSVGT |

866:

LLVPQRKLEV | SVEDVH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

KEGG:

Pfam:

Uniprot:

FOR

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R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"A whole-genome assembly of the domestic cow, Bos taurus."
Zimin A.V. , Delcher A.L. , Florea L. , Kelley D.R. , Schatz M.C. , Puiu D. , Hanrahan F. , Pertea G. , Van Tassell C.P. , Sonstegard T.S. , Marcais G. , Roberts M. , Subramanian P. , Yorke J.A. , Salzberg S.L.
Genome Biol.10:R42.01-R42.10(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: Hereford.

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