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Index > Protein center > E2f8(Gene name) > Mouse
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  • E2f8 (Gene name),
  • Transcription factor E2F8 (Protein name ),  E2F8_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    E2f8;
    Protein name:
    Transcription factor E2F8(E2F-8);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms heterodimers with E2F7 and, to a lesser extent, homodimers. Dimerization is important for DNA binding.
    Function:
    Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    860
    Sequence:
    50:
    MENQKENLFS | EPHKRGLMKS | PLHPSSKANM | VLAEIQPDLG | PLTTPTKPKE | 
    100:
    VSQGEPWTPT | ANLKMLISAV | SPEIRSRDQK | RGLSDNRSAL | PEARDCLHEH | 
    150:
    LSGDEFEKSQ | PSRKEKSLGL | LCHKFLARYP | KYPNPAVNND | ICLDEVAEEL | 
    200:
    NVERRRIYDI | VNVLESLHMV | SRLAKNRYTW | HGRHNLTKTL | GTLKSVGEEN | 
    250:
    KYAEQIMMIK | RKEYEQEFDF | IKSCGIEDHV | IKSHTGQNGH | SDMCFVELPG | 
    300:
    VEFRAASVNS | RKDKSLRVMS | QKFVMLFLVS | TPQIVSLEIA | AKILIGEDHV | 
    350:
    EDLDKSKYKT | KIRRLYDIAN | VLSSLDLIKK | VHVTEERGRK | PAFKWTGPEI | 
    400:
    SPNNSGSSPI | MPLPASLEAE | QSAKENCAKN | LFSTRGKPSF | TRHPSLIKLV | 
    450:
    KSIENDRRKI | SSAPSSPVKS | NKAESSQNSP | PVPNKMAQLA | AICKMQLEEQ | 
    500:
    SSEPRKKVKV | NLARSGHYKP | LAPLDPTVNT | ELELLTPSLI | QPLGVVPLIP | 
    550:
    SPLSSAVPVI | LPQAPSGPSY | AIYLQPAQAQ | MLTPPPGLSP | TVCPTQPSNA | 
    600:
    TGSKDPTDAP | AEKTATDAAT | TGSLQPAPER | HGAKHRSKET | TGDRGTKRMI | 
    650:
    TAEDSGPSSV | KKPKEDLKAL | ENVPTPTPLF | PSGYLIPLTQ | CSSLGPDSVL | 
    700:
    SNTENSGTPS | PNHRIYGSPI | AGVIPVASSE | LTAVNFPPFH | VTPLKLMVSP | 
    750:
    TSMAAVPVGN | SPALNSGHPA | PAQNPSSAIV | NFTLQHLGLI | SPGVQMSASP | 
    800:
    GPGAGTVPVS | PRVEADNLSS | RQRRATNHDS | PVLGQSQLNG | QPVAGTGAQQ | 
    850:
    PVPVTPKGSQ | LVAENFFRTP | GGPTKPTSSP | YTDFDGANKT | SFGTLFVPQR | 
    860:
    KLEVSTEDIH | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E2F-8
    ELISA Kit for Mouse E2F-8
    ELISA Kit for Mouse E2F-8
    ELISA Kit for Mouse E2F-8
    CLIA Kit for Mouse E2F-8
    CLIA Kit for Mouse E2F-8
    CLIA Kit for Mouse E2F-8
    CLIA Kit for Mouse E2F-8
    Polyclonal Antibody for Mouse E2F-8
    Polyclonal Antibody for Mouse E2F-8
    Polyclonal Antibody for Mouse E2F-8
    Polyclonal Antibody for Mouse E2F-8
    Monoclonal Antibody for Mouse E2F-8
    Monoclonal Antibody for Mouse E2F-8
    Monoclonal Antibody for Mouse E2F-8
    Monoclonal Antibody for Mouse E2F-8
    Protein for Mouse E2F-8
    Protein for Mouse E2F-8
    Protein for Mouse E2F-8
    Protein for Mouse E2F-8

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation."
      Maiti B. , Li J. , de Bruin A. , Gordon F. , Timmers C. , Opavsky R. , Patil K. , Tuttle J. , Cleghorn W. , Leone G.
      J. Biol. Chem.280:18211-18220(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;SELF-ASSOCIATION;MUTAGENESIS OF 118-LEU-GLY-119 AND 266-LEU-ARG-267
      strain: Swiss Webster.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Heart.
      tissue: Liver.
      tissue: Spleen.
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Head.
      tissue: Placenta.
    4. 4.
      "Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development."
      Li J. , Ran C. , Li E. , Gordon F. , Comstock G. , Siddiqui H. , Cleghorn W. , Chen H.-Z. , Kornacker K. , Liu C.-G. , Pandit S.K. , Khanizadeh M. , Weinstein M. , Leone G. , de Bruin A.
      Dev. Cell14:62-75(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    5. 5.
      "E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1."
      Weijts B.G. , Bakker W.J. , Cornelissen P.W. , Liang K.H. , Schaftenaar F.H. , Westendorp B. , de Wolf C.A. , Paciejewska M. , Scheele C.L. , Kent L. , Leone G. , Schulte-Merker S. , de Bruin A.
      EMBO J.31:3871-3884(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
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