Protein name:
Transcription factor E2F8 (E2F-8) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms heterodimers with E2F7 and, to a lesser extent, homodimers. Dimerization is important for DNA binding.
Function:
Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MENQKENLFS | EPHKRGLMKS | PLHPSSKANM | VLAEIQPDLG | PLTTPTKPKE |
100:
VSQGEPWTPT | ANLKMLISAV | SPEIRSRDQK | RGLSDNRSAL | PEARDCLHEH |
150:
LSGDEFEKSQ | PSRKEKSLGL | LCHKFLARYP | KYPNPAVNND | ICLDEVAEEL |
200:
NVERRRIYDI | VNVLESLHMV | SRLAKNRYTW | HGRHNLTKTL | GTLKSVGEEN |
250:
KYAEQIMMIK | RKEYEQEFDF | IKSCGIEDHV | IKSHTGQNGH | SDMCFVELPG |
300:
VEFRAASVNS | RKDKSLRVMS | QKFVMLFLVS | TPQIVSLEIA | AKILIGEDHV |
350:
EDLDKSKYKT | KIRRLYDIAN | VLSSLDLIKK | VHVTEERGRK | PAFKWTGPEI |
400:
SPNNSGSSPI | MPLPASLEAE | QSAKENCAKN | LFSTRGKPSF | TRHPSLIKLV |
450:
KSIENDRRKI | SSAPSSPVKS | NKAESSQNSP | PVPNKMAQLA | AICKMQLEEQ |
500:
SSEPRKKVKV | NLARSGHYKP | LAPLDPTVNT | ELELLTPSLI | QPLGVVPLIP |
550:
SPLSSAVPVI | LPQAPSGPSY | AIYLQPAQAQ | MLTPPPGLSP | TVCPTQPSNA |
600:
TGSKDPTDAP | AEKTATDAAT | TGSLQPAPER | HGAKHRSKET | TGDRGTKRMI |
650:
TAEDSGPSSV | KKPKEDLKAL | ENVPTPTPLF | PSGYLIPLTQ | CSSLGPDSVL |
700:
SNTENSGTPS | PNHRIYGSPI | AGVIPVASSE | LTAVNFPPFH | VTPLKLMVSP |
750:
TSMAAVPVGN | SPALNSGHPA | PAQNPSSAIV | NFTLQHLGLI | SPGVQMSASP |
800:
GPGAGTVPVS | PRVEADNLSS | RQRRATNHDS | PVLGQSQLNG | QPVAGTGAQQ |
850:
PVPVTPKGSQ | LVAENFFRTP | GGPTKPTSSP | YTDFDGANKT | SFGTLFVPQR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
Rat
ELISA Kit for Mouse E2F-8
ELISA Kit for Mouse E2F-8
ELISA Kit for Mouse E2F-8
ELISA Kit for Mouse E2F-8
Polyclonal Antibody for Mouse E2F-8
Polyclonal Antibody for Mouse E2F-8
Polyclonal Antibody for Mouse E2F-8
Polyclonal Antibody for Mouse E2F-8
Monoclonal Antibody for Mouse E2F-8
Monoclonal Antibody for Mouse E2F-8
Monoclonal Antibody for Mouse E2F-8
Monoclonal Antibody for Mouse E2F-8
R&D Technical Data
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Precision
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Recovery
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Linearity
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;SELF-ASSOCIATION;MUTAGENESIS OF 118-LEU-GLY-119 AND 266-LEU-ARG-267
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
NOD .
tissue :
Heart .
tissue :
Liver .
tissue :
Spleen .
tissue :
Thymus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Head .
tissue :
Placenta .
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[
Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY