E4f1 ELISA Kit for Mouse(Mus musculus) | EIAab.comE4f1 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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E4f1 (Gene name),

Transcription factor E4F1 (Protein name ), E4F1_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

E4f1;

Protein name:

Transcription factor E4F1;

Alternative:

Putative E3 ubiquitin-protein ligase E4F1;E4F transcription factor 1;Transcription factor phi AP3;Transcription factor E4F;p120E4F;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer; binds DNA as a dimer (By similarity). Forms a complex with CDKN2A and TP53. Interacts with HDAC1, HMGA2 and RASSF1 (By similarity). Interactions with TP53, RB1, ANP32A and probably BMI1 and FHL2 regulate E4F1 activity.

Function:

May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.

Subcellular Location:

Nucleus nucleoplasm Cytoplasm A small fraction is detected in the cytoplasm (By similarity). Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis.

Protein Attributes:

Sequence length:

783

Sequence:

50:

MEGAMAVRVT | AAHTAEARAE | AGREAGEGGV | AAAAALSSGG | FLGLPAPFSE |

100:

EDEDDVHRCG | RCQVEFTALE | DFVQHKIQKT | CHRAPQEALP | TTPAATALLD |

150:

QEVVPTAAEG | GPDEPITVAH | IVVEATSLAE | DISHAPDLVG | SGHIKEVIVA |

200:

AEAEPGDVEM | AEAPGSPNHQ | ELGLLGEGEQ | AHVKLLVNKE | GRYVCMLCHK |

250:

TFKTGSILKA | HMVTHSSRKD | HECKLCGASF | RTKGSLIRHH | RRHTDERPYK |

300:

CAKCGKSFRE | SGALTRHLKS | LTPCTEKIRF | SISKDTAVGK | EEVPAGSSAS |

350:

TVGTVTSSVA | GDPMETSPVI | HLVTDAKGTV | IHEVHVQMQE | LPLGMKALTP |

400:

ESPDSEELPC | SSENSRENLL | HQAMQNSGIV | LERVAGEESA | LEPAPPSGSS |

450:

PQCLGDGSPE | LPLLKVEQIE | TQVASEAATV | PRTHPCPQCS | ETFPTAATLE |

500:

AHKRGHIAPR | PFTCTQCGKA | FPKAYLLKKH | QEVHVHERRF | RCGDCGKLYK |

550:

TIAHVRGHRR | VHSDERPFPC | PQCGKRYKTK | NAQQVHFRTH | LEEKPHVCQF |

600:

CSRGFREKGS | LVRHVRHHTG | EKPFKCYKCG | RGFAEHGTLN | RHLRTKGGCL |

650:

LEVEELLVSE | ESPSAAATVL | AEDPHTVLVE | FSSVVADTQE | YIIEATADDT |

700:

ETSEATEIIE | GTQTEVDSHI | MKVVQQIVHQ | AGAGHQIIVQ | NVTMDQETAL |

750:

GSEATAADTI | TIATPESLTE | QVAMTLASAI | SEGTVLTARA | GPNSTEQATV |

783:

TMVSSEDIEI | LEHGGELVIA | SPEGQLEVQT | VIV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

SMR:

String:

KEGG:

Pfam:

Uniprot:

FOR

ELISA Kit for Mouse Transcription factor E4F1

ELISA Kit for Mouse Transcription factor E4F1

CLIA Kit for Mouse Transcription factor E4F1

CLIA Kit for Mouse Transcription factor E4F1

Polyclonal Antibody for Mouse Transcription factor E4F1

Polyclonal Antibody for Mouse Transcription factor E4F1

Monoclonal Antibody for Mouse Transcription factor E4F1

Monoclonal Antibody for Mouse Transcription factor E4F1

Protein for Mouse Transcription factor E4F1

Protein for Mouse Transcription factor E4F1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Repression of the murine Il-1 beta expression by the murine analog of E4F transcription factor."
Lebedeva T.V. , Singh A.K.
Submitted (1999-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-783 (ISOFORM 1)
strain: C57BL/6J.
tissue: Embryonic testis.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-783 (ISOFORM 5)
strain: C57BL/6.
strain: FVB/N.
strain: NMRI.
tissue: Brain.
tissue: Mammary tumor.
4.

"Repression of adenovirus E1A enhancer activity by a novel zinc finger-containing DNA-binding protein related to the GLI-Kruppel protein."
Fognani C. , Della Valle G. , Babiss L.E.
EMBO J.12:4985-4992(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-783 (ISOFORM 1);FUNCTION;DNA-BINDING;SUBCELLULAR LOCATION;PHOSPHORYLATION;TISSUE SPECIFICITY
strain: BALB/c.
tissue: Liver.
5.

"Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice."
Rooney R.J. , Daniels R.R. , Jenkins N.A. , Gilbert D.J. , Rothammer K. , Morris S.W. , Higgs D.R. , Copeland N.G.
Mamm. Genome9:320-323(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
6.

"p53 is involved in the p120E4F-mediated growth arrest."
Sandy P. , Gostissa M. , Fogal V. , Cecco L.D. , Szalay K. , Rooney R.J. , Schneider C. , Del Sal G.
Oncogene19:188-199(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP53
7.

"pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F."
Fajas L. , Paul C. , Zugasti O. , Le Cam L. , Polanowska J. , Fabbrizio E. , Medema R. , Vignais M.-L. , Sardet C.
Proc. Natl. Acad. Sci. U.S.A.97:7738-7743(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RB1
8.

"The E4F protein is required for mitotic progression during embryonic cell cycles."
Le Cam L. , Lacroix M. , Ciemerych M.A. , Sardet C. , Sicinski P.
Mol. Cell. Biol.24:6467-6475(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;SUBCELLULAR LOCATION
9.

"The role of LANP and ataxin 1 in E4F-mediated transcriptional repression."
Cvetanovic M. , Rooney R.J. , Garcia J.J. , Toporovskaya N. , Zoghbi H.Y. , Opal P.
EMBO Rep.8:671-677(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ANP32A

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