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Index > Protein center > EDEM3(Gene name) > Human
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  • EDEM3 (Gene name),
  • ER degradation-enhancing alpha-mannosidase-like 3 (Protein name ),  EDEM3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EDEM3(C1orf22);
    Protein name:
    ER degradation-enhancing alpha-mannosidase-like 3;
    Alternative:
    Alpha-1,2-mannosidase EDEM3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity.
    Subcellular Location:
    Endoplasmic reticulum lumen
    Protein Attributes:
    Sequence length:
    932
    Sequence:
    50:
    MSEAGGRGCG | SPVPQRARWR | LVAATAAFCL | VSATSVWTAG | AEPMSREEKQ | 
    100:
    KLGNQVLEMF | DHAYGNYMEH | AYPADELMPL | TCRGRVRGQE | PSRGDVDDAL | 
    150:
    GKFSLTLIDS | LDTLVVLNKT | KEFEDAVRKV | LRDVNLDNDV | VVSVFETNIR | 
    200:
    VLGGLLGGHS | LAIMLKEKGE | YMQWYNDELL | QMAKQLGYKL | LPAFNTTSGL | 
    250:
    PYPRINLKFG | IRKPEARTGT | ETDTCTACAG | TLILEFAALS | RFTGATIFEE | 
    300:
    YARKALDFLW | EKRQRSSNLV | GVTINIHTGD | WVRKDSGVGA | GIDSYYEYLL | 
    350:
    KAYVLLGDDS | FLERFNTHYD | AIMRYISQPP | LLLDVHIHKP | MLNARTWMDA | 
    400:
    LLAFFPGLQV | LKGDIRPAIE | THEMLYQVIK | KHNFLPEAFT | TDFRVHWAQH | 
    450:
    PLRPEFAEST | YFLYKATGDP | YYLEVGKTLI | ENLNKYARVP | CGFAAMKDVR | 
    500:
    TGSHEDRMDS | FFLAEMFKYL | YLLFADKEDI | IFDIEDYIFT | TEAHLLPLWL | 
    550:
    STTNQSISKK | NTTSEYTELD | DSNFDWTCPN | TQILFPNDPL | YAQSIREPLK | 
    600:
    NVVDKSCPRG | IIRVEESFRS | GAKPPLRARD | FMATNPEHLE | ILKKMGVSLI | 
    650:
    HLKDGRVQLV | QHAIQAASSI | DAEDGLRFMQ | EMIELSSQQQ | KEQQLPPRAV | 
    700:
    QIVSHPFFGR | VVLTAGPAQF | GLDLSKHKET | RGFVASSKPS | NGCSELTNPE | 
    750:
    AVMGKIALIQ | RGQCMFAEKA | RNIQNAGAIG | GIVIDDNEGS | SSDTAPLFQM | 
    800:
    AGDGKDTDDI | KIPMLFLFSK | EGSIILDAIR | EYEEVEVLLS | DKAKDRDPEM | 
    850:
    ENEEQPSSEN | DSQNQSGEQI | SSSSQEVDLV | DQESSEENSL | NSHPESLSLA | 
    900:
    DMDNAASISP | SEQTSNPTEN | HETTNLNGEC | TDLDNQLQEQ | SETEEDSNPN | 
    932:
    VSWGKKVQPI | DSILADWNED | IEAFEMMEKD | EL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human ER degradation-enhancing alpha-mannosidase-like 3
    ELISA Kit for Human ER degradation-enhancing alpha-mannosidase-like 3
    CLIA Kit for Human ER degradation-enhancing alpha-mannosidase-like 3
    CLIA Kit for Human ER degradation-enhancing alpha-mannosidase-like 3
    Polyclonal Antibody for Human ER degradation-enhancing alpha-mannosidase-like 3
    Polyclonal Antibody for Human ER degradation-enhancing alpha-mannosidase-like 3
    Monoclonal Antibody for Human ER degradation-enhancing alpha-mannosidase-like 3
    Monoclonal Antibody for Human ER degradation-enhancing alpha-mannosidase-like 3
    Protein for Human ER degradation-enhancing alpha-mannosidase-like 3
    Protein for Human ER degradation-enhancing alpha-mannosidase-like 3

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-319 AND 853-932 (ISOFORM 1)
      tissue: Brain.
      tissue: Lung.
    4. 4.
      "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus."
      Sood R. , Bonner T.I. , Malakowska I. , Stephan D.A. , Robbins C.M. , Connors T.D. , Morgenbesser S.D. , Su K. , Faruque M.U. , Pinkett H. , Graham C. , Baxevanis A.D. , Klinger K.W. , Landes G.M. , Trent J.M. , Carpten J.D.
      Genomics73:211-222(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-932 (ISOFORM 1)
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 553-932 (ISOFORM 1);VARIANT SER-820
      tissue: Testis.
    6. 6.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-195
      tissue: Liver.
    7. 7.
      "EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step."
      Ninagawa S. , Okada T. , Sumitomo Y. , Kamiya Y. , Kato K. , Horimoto S. , Ishikawa T. , Takeda S. , Sakuma T. , Yamamoto T. , Mori K.
      J. Cell Biol.206:347-356(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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