Protein name:
Endothelial differentiation-related factor 1 (EDF-1) ;
Alternative:
Multiprotein-bridging factor 1 (MBF1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with TBP and the transcription factor IID (TFIID) complex, NR5A2, NR1H3 and PPARG. Interaction with TBP is regulated by phosphorylation. Binds NR5A1, ATF1, FOS and JUN via their conserved basic region. Binding to calmodulin is regulated by calcium and phosphorylation of the IQ motif.
Function:
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
Subcellular Location:
Cytoplasm
Nucleus
Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
Protein Attributes:
50:
MAESDWDTVT | VLRKKGPTAA | QAKSKQAILA | AQRRGEDVET | SKKWAAGQNK |
100:
QHSITKNTAK | LDRETEELHH | DRVTLEVGKV | IQQGRQSKGL | TQKDLATKIN |
148:
EKPQVIADYE | SGRAIPNNQV | LGKIERAIGL | KLRGKDIGKP | IEKGPRAK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Bovine
Chicken
ELISA Kit for Human EDF-1
ELISA Kit for Human EDF-1
ELISA Kit for Human EDF-1
ELISA Kit for Human EDF-1
ELISA Kit for Human EDF-1
Polyclonal Antibody for Human EDF-1
Polyclonal Antibody for Human EDF-1
Polyclonal Antibody for Human EDF-1
Polyclonal Antibody for Human EDF-1
Polyclonal Antibody for Human EDF-1
Monoclonal Antibody for Human EDF-1
Monoclonal Antibody for Human EDF-1
Monoclonal Antibody for Human EDF-1
Monoclonal Antibody for Human EDF-1
Monoclonal Antibody for Human EDF-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION;FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;INTERACTION WITH TBP; NR5A1; FOS; JUN AND ATF1;SUBCELLULAR LOCATION;FUNCTION
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Pancreas .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-13 AND 99-113;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Cervix carcinoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CALM AND TBP;MUTAGENESIS OF THR-40; THR-58; THR-91 AND SER-111;PHOSPHORYLATION;SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NR5A2; NR1H3; PPARG AND TFIID COMPLEX;TISSUE SPECIFICITY;FUNCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF THR-65; THR-74 AND SER-87;INTERACTION WITH TBP AND CALM;PHOSPHORYLATION;SUBCELLULAR LOCATION;FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 71-148