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Index > Protein center > Edf1(Gene name) > Mouse
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  • Edf1 (Gene name),
  • Endothelial differentiation-related factor 1 (Protein name ),  EDF1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    Edf1;
    Protein name:
    Endothelial differentiation-related factor 1(EDF-1);
    Alternative:
    Multiprotein-bridging factor 1(MBF1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with TBP and the transcription factor IID (TFIID) complex, NR5A2, NR1H3 and PPARG. Interaction with TBP is regulated by phosphorylation. Binds NR5A1, ATF1, FOS and JUN via their conserved basic region. Binding to calmodulin is regulated by calcium and phosphorylation of the IQ motif.
    Function:
    Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
    Subcellular Location:
    Cytoplasm Nucleus Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
    Protein Attributes:
    Sequence length:
    148
    Sequence:
    50:
    MAESDWDTVT | VLRKKGPTAA | QAKSKQAILA | AQRRGEDVET | SKKWAAGQNK | 
    100:
    QHSITKNTAK | LDRETEELHH | DRVTLEVGKV | IQRGRQSKGL | TQKDLATKIN | 
    148:
    EKPQVIADYE | SGRAIPNNQV | LGKIERAIGL | KLRGKDIGKP | IEKGPKAK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    KEGG:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse EDF-1
    ELISA Kit for Mouse EDF-1
    ELISA Kit for Mouse EDF-1
    ELISA Kit for Mouse EDF-1
    ELISA Kit for Mouse EDF-1
    CLIA Kit for Mouse EDF-1
    CLIA Kit for Mouse EDF-1
    CLIA Kit for Mouse EDF-1
    CLIA Kit for Mouse EDF-1
    CLIA Kit for Mouse EDF-1
    Polyclonal Antibody for Mouse EDF-1
    Polyclonal Antibody for Mouse EDF-1
    Polyclonal Antibody for Mouse EDF-1
    Polyclonal Antibody for Mouse EDF-1
    Polyclonal Antibody for Mouse EDF-1
    Monoclonal Antibody for Mouse EDF-1
    Monoclonal Antibody for Mouse EDF-1
    Monoclonal Antibody for Mouse EDF-1
    Monoclonal Antibody for Mouse EDF-1
    Monoclonal Antibody for Mouse EDF-1
    Protein for Mouse EDF-1
    Protein for Mouse EDF-1
    Protein for Mouse EDF-1
    Protein for Mouse EDF-1
    Protein for Mouse EDF-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains."
      Inoue S. , Sano H. , Ohta M.
      Biochem. Biophys. Res. Commun.268:553-561(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    2. 2.
      "Cloning and characterization of murine EDF-1."
      De Benedictis L. , Mariotti M. , Dragoni I. , Maier J.A.M.
      Gene275:299-304(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Kidney.
      tissue: Tongue.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    5. 5.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
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