Protein name:
Polycomb protein EED ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2 (By similarity). The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12 (By similarity). Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit (By similarity). Interacts with HDAC, HDAC2, histone H1 and YY1 (By similarity). May interact with ITGA4, ITGAE and ITGB7 (By similarity). Interacts with EZH2. Interacts with MLL in adult brain.
Function:
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extra-embryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.
Subcellular Location:
Nucleus
Chromosome
Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extra-embryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST.
Protein Attributes:
50:
MSEREVSTAP | AGTDMPAAKK | QKLSSDENSN | PDLSGDENDD | AVSIESGTNT |
100:
ERPDTPTNTP | NAPGRKSWGK | GKWKSKKCKY | SFKCVNSLKE | DHNQPLFGVQ |
150:
FNWHSKEGDP | LVFATVGSNR | VTLYECHSQG | EIRLLQSYVD | ADADENFYTC |
200:
AWTYDSNTSH | PLLAVAGSRG | IIRIINPITM | QCIKHYVGHG | NAINELKFHP |
250:
RDPNLLLSVS | KDHALRLWNI | QTDTLVAIFG | GVEGHRDEVL | SADYDLLGEK |
300:
IMSCGMDHSL | KLWRINSKRM | MNAIKESYDY | NPNKTNRPFI | SQKIHFPDFS |
350:
TRDIHRNYVD | CVRWLGDLIL | SKSCENAIVC | WKPGKMEDDI | DKIKPSESNV |
400:
TILGRFDYSQ | CDIWYMRFSM | DFWQKMLALG | NQVGKLYVWD | LEVEDPHKAK |
441:
CTTLTHHKCG | AAIRQTSFSR | DSSILIAVCD | DASIWRWDRL | R
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Chicken
Bovine
ELISA Kit for Mouse Polycomb protein EED
ELISA Kit for Mouse Polycomb protein EED
ELISA Kit for Mouse Polycomb protein EED
ELISA Kit for Mouse Polycomb protein EED
CLIA Kit for Mouse Polycomb protein EED
CLIA Kit for Mouse Polycomb protein EED
CLIA Kit for Mouse Polycomb protein EED
CLIA Kit for Mouse Polycomb protein EED
Polyclonal Antibody for Mouse Polycomb protein EED
Polyclonal Antibody for Mouse Polycomb protein EED
Polyclonal Antibody for Mouse Polycomb protein EED
Polyclonal Antibody for Mouse Polycomb protein EED
Monoclonal Antibody for Mouse Polycomb protein EED
Monoclonal Antibody for Mouse Polycomb protein EED
Monoclonal Antibody for Mouse Polycomb protein EED
Monoclonal Antibody for Mouse Polycomb protein EED
Protein for Mouse Polycomb protein EED
Protein for Mouse Polycomb protein EED
Protein for Mouse Polycomb protein EED
Protein for Mouse Polycomb protein EED
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);CHARACTERIZATION OF MUTANTS ASN-193 AND PRO-196;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain :
Swiss Webster .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;ALTERNATIVE INITIATION;TISSUE SPECIFICITY;MUTAGENESIS OF ILE-193 AND LEU-196
4.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Embryo .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
Czech II .
tissue :
Mammary tumor .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH EZH2;MUTAGENESIS OF ILE-193 AND LEU-196
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CHARACTERIZATION OF MUTANTS ASN-193 AND PRO-196
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CHARACTERIZATION OF MUTANT ASN-193
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
18.
"Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation."
Kuzmichev A.
,
Margueron R.
,
Vaquero A.
,
Preissner T.S.
,
Scher M.
,
Kirmizis A.
,
Ouyang X.
,
Brockdorff N.
,
Abate-Shen C.
,
Farnham P.J.
,
Reinberg D.
Proc. Natl. Acad. Sci. U.S.A.102:1859-1864(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EZH2
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH EZH2 AND KMT2A/MLL1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF LEU-196
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ALTERNATIVE INITIATION;INTERACTION WITH EZH2
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE PRC2/EED-EZH1 COMPLEX
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE PRC2 COMPLEX
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ARNTL/BMAL1
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 81-441 IN COMPLEX WITH EZH2;MUTAGENESIS OF LEU-246; LEU-315 AND GLY-316