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Index > Protein center > Eed(Gene name) > Mouse
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  • Eed (Gene name),
  • Polycomb protein EED (Protein name ),  EED_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Eed;
    Protein name:
    Polycomb protein EED;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2 (By similarity). The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12 (By similarity). Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit (By similarity). Interacts with HDAC, HDAC2, histone H1 and YY1 (By similarity). May interact with ITGA4, ITGAE and ITGB7 (By similarity). Interacts with EZH2. Interacts with MLL in adult brain.
    Function:
    Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extra-embryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.
    Subcellular Location:
    Nucleus Chromosome Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extra-embryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST.
    Protein Attributes:
    Sequence length:
    441
    Sequence:
    50:
    MSEREVSTAP | AGTDMPAAKK | QKLSSDENSN | PDLSGDENDD | AVSIESGTNT | 
    100:
    ERPDTPTNTP | NAPGRKSWGK | GKWKSKKCKY | SFKCVNSLKE | DHNQPLFGVQ | 
    150:
    FNWHSKEGDP | LVFATVGSNR | VTLYECHSQG | EIRLLQSYVD | ADADENFYTC | 
    200:
    AWTYDSNTSH | PLLAVAGSRG | IIRIINPITM | QCIKHYVGHG | NAINELKFHP | 
    250:
    RDPNLLLSVS | KDHALRLWNI | QTDTLVAIFG | GVEGHRDEVL | SADYDLLGEK | 
    300:
    IMSCGMDHSL | KLWRINSKRM | MNAIKESYDY | NPNKTNRPFI | SQKIHFPDFS | 
    350:
    TRDIHRNYVD | CVRWLGDLIL | SKSCENAIVC | WKPGKMEDDI | DKIKPSESNV | 
    400:
    TILGRFDYSQ | CDIWYMRFSM | DFWQKMLALG | NQVGKLYVWD | LEVEDPHKAK | 
    441:
    CTTLTHHKCG | AAIRQTSFSR | DSSILIAVCD | DASIWRWDRL | R
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Polycomb protein EED
    ELISA Kit for Mouse Polycomb protein EED
    ELISA Kit for Mouse Polycomb protein EED
    ELISA Kit for Mouse Polycomb protein EED
    CLIA Kit for Mouse Polycomb protein EED
    CLIA Kit for Mouse Polycomb protein EED
    CLIA Kit for Mouse Polycomb protein EED
    CLIA Kit for Mouse Polycomb protein EED
    Polyclonal Antibody for Mouse Polycomb protein EED
    Polyclonal Antibody for Mouse Polycomb protein EED
    Polyclonal Antibody for Mouse Polycomb protein EED
    Polyclonal Antibody for Mouse Polycomb protein EED
    Monoclonal Antibody for Mouse Polycomb protein EED
    Monoclonal Antibody for Mouse Polycomb protein EED
    Monoclonal Antibody for Mouse Polycomb protein EED
    Monoclonal Antibody for Mouse Polycomb protein EED
    Protein for Mouse Polycomb protein EED
    Protein for Mouse Polycomb protein EED
    Protein for Mouse Polycomb protein EED
    Protein for Mouse Polycomb protein EED

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    Precision
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    Recovery
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    Linearity
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE PRC2/EED-EZH1 COMPLEX
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 81-441 IN COMPLEX WITH EZH2;MUTAGENESIS OF LEU-246; LEU-315 AND GLY-316
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