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Index > Protein center > Efnb1(Gene name) > Mouse
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  • Efnb1 (Gene name),
  • Ephrin-B1 (Protein name ),  EFNB1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Efnb1(Epl2;Eplg2;Lerk2;Stra1);
    Protein name:
    Ephrin-B1;
    Alternative:
    ELK ligand(ELK-L);CEK5 receptor ligand(CEK5-L);Stimulated by retinoic acid gene 1 protein;EPH-related receptor tyrosine kinase ligand 2(LERK-2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with GRIP1 and GRIP2.
    Function:
    Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    345
    Sequence:
    50:
    MARPGQRWLS | KWLVAMVVLT | LCRLATPLAK | NLEPVSWSSL | NPKFLSGKGL | 
    100:
    VIYPKIGDKL | DIICPRAEAG | RPYEYYKLYL | VRPEQAAACS | TVLDPNVLVT | 
    150:
    CNKPHQEIRF | TIKFQEFSPN | YMGLEFKKYH | DYYITSTSNG | SLEGLENREG | 
    200:
    GVCRTRTMKI | VMKVGQDPNA | VTPEQLTTSR | PSKESDNTVK | TATQAPGRGS | 
    250:
    QGDSDGKHET | VNQEEKSGPG | AGGGGSGDSD | SFFNSKVALF | AAVGAGCVIF | 
    300:
    LLIIIFLTVL | LLKLRKRHRK | HTQQRAAALS | LSTLASPKGG | SGTAGTEPSD | 
    345:
    IIIPLRTTEN | NYCPHYEKVS | GDYGHPVYIV | QEMPPQSPAN | IYYKV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ephrin-B1
    ELISA Kit for Mouse Ephrin-B1
    ELISA Kit for Mouse Ephrin-B1
    ELISA Kit for Mouse Ephrin-B1
    CLIA Kit for Mouse Ephrin-B1
    CLIA Kit for Mouse Ephrin-B1
    CLIA Kit for Mouse Ephrin-B1
    CLIA Kit for Mouse Ephrin-B1
    Polyclonal Antibody for Mouse Ephrin-B1
    Polyclonal Antibody for Mouse Ephrin-B1
    Polyclonal Antibody for Mouse Ephrin-B1
    Polyclonal Antibody for Mouse Ephrin-B1
    Monoclonal Antibody for Mouse Ephrin-B1
    Monoclonal Antibody for Mouse Ephrin-B1
    Monoclonal Antibody for Mouse Ephrin-B1
    Monoclonal Antibody for Mouse Ephrin-B1
    Protein for Mouse Ephrin-B1
    Protein for Mouse Ephrin-B1
    Protein for Mouse Ephrin-B1
    Protein for Mouse Ephrin-B1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elk."
      Fletcher F.A. , Renshaw B. , Hollingsworth T. , Baum P. , Lyman S.D. , Jenkins N.A. , Gilbert D.J. , Copeland N.G. , Davison B.L.
      Genomics24:127-132(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/Sv.
    2. 2.
      "Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2)."
      Bouillet P. , Oulad-Abdelghani M. , Vicaire S. , Garnier J.-M. , Schuhbaur B. , Dolle P. , Chambon P.
      Dev. Biol.170:420-433(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase."
      Shao H. , Lou L. , Pandey A. , Pasquale E.B. , Dixit V.M.
      J. Biol. Chem.269:26606-26609(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary gland.
    5. 5.
      "Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons."
      Imondi R. , Wideman C. , Kaprielian Z.
      Development127:1397-1410(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P. , Tweedie-Cullen R. , Livingstone-Zatchej M. , Weinandy F. , Waidelich M. , Longo D. , Gehrig P. , Potthast F. , Rutishauser D. , Gerrits B. , Panse C. , Schlapbach R. , Mansuy I.M.
      Mol. Cell. Proteomics6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain cortex.
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