EFNB2 ELISA Kit for Human(Homo sapiens) | EIAab.comEFNB2 ELISA Kit for Human(Homo sapiens) | EIAab.com

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EFNB2 (Gene name),

Ephrin-B2 (Protein name ), EFNB2_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

EFNB2(EPLG5;HTKL;LERK5);

Protein name:

Ephrin-B2;

Alternative:

HTK ligand(HTK-L);EPH-related receptor tyrosine kinase ligand 5(LERK-5);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PDZRN3 (By similarity). Binds to the receptor tyrosine kinases EPHA4, EPHB4 and EPHA3. Binds to Hendra virus and Nipah virus G protein.

Function:

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

333

Sequence:

50:

MAVRRDSVWK | YCWGVLMVLC | RTAISKSIVL | EPIYWNSSNS | KFLPGQGLVL |

100:

YPQIGDKLDI | ICPKVDSKTV | GQYEYYKVYM | VDKDQADRCT | IKKENTPLLN |

150:

CAKPDQDIKF | TIKFQEFSPN | LWGLEFQKNK | DYYIISTSNG | SLEGLDNQEG |

200:

GVCQTRAMKI | LMKVGQDASS | AGSTRNKDPT | RRPELEAGTN | GRSSTTSPFV |

250:

KPNPGSSTDG | NSAGHSGNNI | LGSEVALFAG | IASGCIIFIV | IIITLVVLLL |

300:

KYRRRHRKHS | PQHTTTLSLS | TLATPKRSGN | NNGSEPSDII | IPLRTADSVF |

333:

CPHYEKVSGD | YGHPVYIVQE | MPPQSPANIY | YKV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000245323

Pfam:

UniGene:

KEGG:

MIM:

SMR:

String:

Uniprot:

FOR

ELISA Kit for Human Ephrin-B2

ELISA Kit for Human Ephrin-B2

CLIA Kit for Human Ephrin-B2

CLIA Kit for Human Ephrin-B2

Polyclonal Antibody for Human Ephrin-B2

Polyclonal Antibody for Human Ephrin-B2

Monoclonal Antibody for Human Ephrin-B2

Monoclonal Antibody for Human Ephrin-B2

Protein for Human Ephrin-B2

Protein for Human Ephrin-B2

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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References

1.

"Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases."
Cerretti D.P. , Vanden Bos T. , Nelson N. , Kozlosky C.J. , Reddy P. , Maraskovsky E. , Park L.S. , Lyman S.D. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Fletcher R.A.
Mol. Immunol.32:1197-1205(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk."
Bennett B.D. , Zeigler F.C. , Gu Q. , Fendly B. , Goddard A.D. , Gillett N. , Matthews W.
Proc. Natl. Acad. Sci. U.S.A.92:1866-1870(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
3.

"Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas."
Vogt T. , Stolz W. , Welsh J. , Jung B. , Kerbel R.S. , Kobayashi H. , Landthaler M. , McClelland M.
Clin. Cancer Res.4:791-797(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"The DNA sequence and analysis of human chromosome 13."
Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
6.

"Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells."
Fueller T. , Korff T. , Kilian A. , Dandekar G. , Augustin H.G.
J. Cell Sci.116:2461-2470(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS
7.

"EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus."
Negrete O.A. , Levroney E.L. , Aguilar H.C. , Bertolotti-Ciarlet A. , Nazarian R. , Tajyar S. , Lee B.
Nature436:401-405(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NIPAH VIRUS PROTEIN G
8.

"Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus."
Negrete O.A. , Wolf M.C. , Aguilar H.C. , Enterlein S. , Wang W. , Muehlberger E. , Su S.V. , Bertolotti-Ciarlet A. , Flick R. , Lee B.
PLoS Pathog.2:78-86(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NIPAH VIRUS PROTEIN G;MUTAGENESIS OF 121-LEU-TRP-122
9.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity."
Chrencik J.E. , Brooun A. , Kraus M.L. , Recht M.I. , Kolatkar A.R. , Han G.W. , Seifert J.M. , Widmer H. , Auer M. , Kuhn P.
J. Biol. Chem.281:28185-28192(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 28-165 IN COMPLEX WITH EPHB4;DISULFIDE BONDS
11.

"Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2."
Bowden T.A. , Aricescu A.R. , Gilbert R.J. , Grimes J.M. , Jones E.Y. , Stuart D.I.
Nat. Struct. Mol. Biol.15:567-572(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 28-165 IN COMPLEXES WITH NIPAH VIRUS AND HENDRA VIRUS GLYCOPROTEINS
12.

"Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling."
Bowden T.A. , Aricescu A.R. , Nettleship J.E. , Siebold C. , Rahman-Huq N. , Owens R.J. , Stuart D.I. , Jones E.Y.
Structure17:1386-1397(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 27-167 IN COMPLEX WITH EPHA4;DISULFIDE BONDS
13.

"Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity."
Qin H. , Noberini R. , Huan X. , Shi J. , Pasquale E.B. , Song J.
J. Biol. Chem.285:644-654(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 27-169 IN COMPLEX WITH EPHA4

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