Efnb2 ELISA Kit for Mouse(Mus musculus) | EIAab.comEfnb2 ELISA Kit for Mouse(Mus musculus)

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Efnb2 (Gene name),

Ephrin-B2 (Protein name ), EFNB2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Efnb2(Elf2;Epl5;Eplg5;Htkl;Lerk5);

Protein name:

Ephrin-B2;

Alternative:

EPH-related receptor tyrosine kinase ligand 5(LERK-5);ELF-2;HTK ligand(HTK-L);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with PDZRN3. Binds to the ephrin receptor EPHA3, EPHA4 and EPHB4.

Function:

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

336

Sequence:

50:

100:

150:

200:

250:

300:

336:

SVFCPHYEKV | SGDYGHPVYI | VQEMPPQSPA | NIYYKV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00812

SMR:

P52800

UniGene:

Mm.209813

String:

P52800

KEGG:

mmu:13642

Uniprot:

P52800

FOR

ELISA Kit for Mouse Ephrin-B2

CLIA Kit for Mouse Ephrin-B2

Polyclonal Antibody for Mouse Ephrin-B2

Monoclonal Antibody for Mouse Ephrin-B2

Protein for Mouse Ephrin-B2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases."
Cerretti D.P. , Vanden Bos T. , Nelson N. , Kozlosky C.J. , Reddy P. , Maraskovsky E. , Park L.S. , Lyman S.D. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Fletcher R.A.
Mol. Immunol.32:1197-1205(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk."
Bennett B.D. , Zeigler F.C. , Gu Q. , Fendly B. , Goddard A.D. , Gillett N. , Matthews W.
Proc. Natl. Acad. Sci. U.S.A.92:1866-1870(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: CB57BL/6J X SJL/J.
3.

"ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites."
Bergemann A.D. , Cheng H.J. , Brambilla R. , Klein R. , Flanagan J.G.
Mol. Cell. Biol.15:4921-4929(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: ICR.
tissue: Brain.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
5.

"Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons."
Imondi R. , Wideman C. , Kaprielian Z.
Development127:1397-1410(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Crystal structure of an ephrin ectodomain."
Toth J. , Cutforth T. , Gelinas A.D. , Bethoney K.A. , Bard J. , Harrison C.J.
Dev. Cell1:83-92(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 30-170
7.

"Crystal structure of an Eph receptor-ephrin complex."
Himanen J.-P. , Rajashankar K.R. , Lackmann M. , Cowan C.A. , Henkemeyer M. , Nikolov D.B.
Nature414:933-938(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 31-168 IN COMPLEX WITH EPHB2

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