Egln1 ELISA Kit for Mouse(Mus musculus) | EIAab.comEgln1 ELISA Kit for Mouse(Mus musculus)

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Egln1 (Gene name),

Egl nine homolog 1 (Protein name ), EGLN1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Egln1;

Protein name:

Egl nine homolog 1;

Alternative:

SM-20(PHD2);Hypoxia-inducible factor prolyl hydroxylase 2(HIF-PH2;HIF-prolyl hydroxylase 2;HPH-2);SM-20;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer. Interacts with ING4.

Function:

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

400

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q91YE3

UniGene:

Mm.140619

Pfam:

PF03171

STRING:

10090.ENSMUSP00000034469

KEGG:

mmu:112405

Pfam:

PF13640

String:

Q91YE3

Uniprot:

Q91YE3

FOR

ELISA Kit for Mouse Egl nine homolog 1

CLIA Kit for Mouse Egl nine homolog 1

Polyclonal Antibody for Mouse Egl nine homolog 1

Monoclonal Antibody for Mouse Egl nine homolog 1

Protein for Mouse Egl nine homolog 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"Characterization and comparative analysis of the EGLN gene family."
Taylor M.S.
Gene275:125-132(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-400
3.

"Mammalian EGLN genes have distinct patterns of mRNA expression and regulation."
Lieb M.E. , Menzies K. , Moschella M.C. , Ni R. , Taubman M.B.
Biochem. Cell Biol.80:421-426(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-400;TISSUE SPECIFICITY
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-400
tissue: Mammary gland.
5.

"SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation."
Moschella M.C. , Menzies K. , Tsao L. , Lieb M.A. , Kohtz J.D. , Kohtz D.S. , Taubman M.B.
Gene Expr.8:59-66(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
6.

"Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure."
Minamishima Y.A. , Moslehi J. , Bardeesy N. , Cullen D. , Bronson R.T. , Kaelin W.G. Jr.
Blood111:3236-3244(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
7.

"Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene."
Wu S. , Nishiyama N. , Kano M.R. , Morishita Y. , Miyazono K. , Itaka K. , Chung U.I. , Kataoka K.
Mol. Ther.16:1227-1234(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
8.

"Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice."
Duan L.J. , Takeda K. , Fong G.H.
Am. J. Pathol.178:1881-1890(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION

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