"Characterization and comparative analysis of the EGLN gene family."
Taylor M.S.
Gene275:125-132(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor."
Hirsila M. , Koivunen P. , Gunzler V. , Kivirikko K.I. , Myllyharju J.
J. Biol. Chem.278:30772-30780(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , Yamamoto J. , Saito K. , Kawai Y. , Isono Y. , Nakamura Y. , Nagahari K. , Murakami K. , Yasuda T. , Iwayanagi T. , Wagatsuma M. , Shiratori A. , Sudo H. , Hosoiri T. , Kaku Y. , Kodaira H. , Kondo H. , Sugawara M. , Takahashi M. , Kanda K. , Yokoi T. , Furuya T. , Kikkawa E. , Omura Y. , Abe K. , Kamihara K. , Katsuta N. , Sato K. , Tanikawa M. , Yamazaki M. , Ninomiya K. , Ishibashi T. , Yamashita H. , Murakawa K. , Fujimori K. , Tanai H. , Kimata M. , Watanabe M. , Hiraoka S. , Chiba Y. , Ishida S. , Ono Y. , Takiguchi S. , Watanabe S. , Yosida M. , Hotuta T. , Kusano J. , Kanehori K. , Takahashi-Fujii A. , Hara H. , Tanase T.-O. , Nomura Y. , Togiya S. , Komai F. , Hara R. , Takeuchi K. , Arita M. , Imose N. , Musashino K. , Yuuki H. , Oshima A. , Sasaki N. , Aotsuka S. , Yoshikawa Y. , Matsunawa H. , Ichihara T. , Shiohata N. , Sano S. , Moriya S. , Momiyama H. , Satoh N. , Takami S. , Terashima Y. , Suzuki O. , Nakagawa S. , Senoh A. , Mizoguchi H. , Goto Y. , Shimizu F. , Wakebe H. , Hishigaki H. , Watanabe T. , Sugiyama A. , Takemoto M. , Kawakami B. , Yamazaki M. , Watanabe K. , Kumagai A. , Itakura S. , Fukuzumi Y. , Fujimori Y. , Komiyama M. , Tashiro H. , Tanigami A. , Fujiwara T. , Ono T. , Yamada K. , Fujii Y. , Ozaki K. , Hirao M. , Ohmori Y. , Kawabata A. , Hikiji T. , Kobatake N. , Inagaki H. , Ikema Y. , Okamoto S. , Okitani R. , Kawakami T. , Noguchi S. , Itoh T. , Shigeta K. , Senba T. , Matsumura K. , Nakajima Y. , Mizuno T. , Morinaga M. , Sasaki M. , Togashi T. , Oyama M. , Hata H. , Watanabe M. , Komatsu T. , Mizushima-Sugano J. , Satoh T. , Shirai Y. , Takahashi Y. , Nakagawa K. , Okumura K. , Nagase T. , Nomura N. , Kikuchi H. , Masuho Y. , Yamashita R. , Nakai K. , Yada T. , Nakamura Y. , Ohara O. , Isogai T. , Sugano S. more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation."
Epstein A.C.R. , Gleadle J.M. , McNeill L.A. , Hewitson K.S. , O'Rourke J. , Mole D.R. , Mukherji M. , Metzen E. , Wilson M.I. , Dhanda A. , Tian Y.M. , Masson N. , Hamilton D.L. , Jaakkola P. , Barstead R. , Hodgkin J. , Maxwell P.H. , Pugh C.W. , Schofield C.J. , Ratcliffe P.J. more...
Cell107:43-54(2001) [PubMed] [Europe PMC] [Abstract]

"HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus."
Semenza G.L.
Cell107:1-3(2001) [PubMed] [Europe PMC] [Abstract]

"A conserved family of prolyl-4-hydroxylases that modify HIF."
Bruick R.K. , McKnight S.L.
Science294:1337-1340(2001) [PubMed] [Europe PMC] [Abstract]

"Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors."
Oehme F. , Ellinghaus P. , Kolkhof P. , Smith T.J. , Ramakrishnan S. , Huetter J. , Schramm M. , Flamme I.
Biochem. Biophys. Res. Commun.296:343-349(2002) [PubMed] [Europe PMC] [Abstract]

"Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3."
Huang J. , Zhao Q. , Mooney S.M. , Lee F.S.
J. Biol. Chem.277:39792-39800(2002) [PubMed] [Europe PMC] [Abstract]

"Differential regulation of HIF-1alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells."
Cioffi C.L. , Qin Liu X. , Kosinski P.A. , Garay M. , Bowen B.R.
Biochem. Biophys. Res. Commun.303:947-953(2003) [PubMed] [Europe PMC] [Abstract]

"Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing."
Metzen E. , Berchner-Pfannschmidt U. , Stengel P. , Marxsen J.H. , Stolze I. , Klinger M. , Huang W.Q. , Wotzlaw C. , Hellwig-Burgel T. , Jelkmann W. , Acker H. , Fandrey J.
J. Cell Sci.116:1319-1326(2003) [PubMed] [Europe PMC] [Abstract]

"Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor."
Appelhoff R.J. , Tian Y.M. , Raval R.R. , Turley H. , Harris A.L. , Pugh C.W. , Ratcliffe P.J. , Gleadle J.M.
J. Biol. Chem.279:38458-38465(2004) [PubMed] [Europe PMC] [Abstract]

"Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer."
Lee S. , Nakamura E. , Yang H. , Wei W. , Linggi M.S. , Sajan M.P. , Farese R.V. , Freeman R.S. , Carter B.D. , Kaelin W.G. Jr. , Schlisio S.
Cancer Cell8:155-167(2005) [PubMed] [Europe PMC] [Abstract]

"Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL."
Xie L. , Xiao K. , Whalen E.J. , Forrester M.T. , Freeman R.S. , Fong G. , Gygi S.P. , Lefkowitz R.J. , Stamler J.S.
Sci. Signal.2:RA33-RA33(2009) [PubMed] [Europe PMC] [Abstract]

"Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells."
Liu Y. , Huo Z. , Yan B. , Lin X. , Zhou Z.N. , Liang X. , Zhu W. , Liang D. , Li L. , Liu Y. , Zhao H. , Sun Y. , Chen Y.H.
Biochem. Biophys. Res. Commun.401:231-237(2010) [PubMed] [Europe PMC] [Abstract]

"PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer."
Su Y. , Loos M. , Giese N. , Hines O.J. , Diebold I. , Gorlach A. , Metzen E. , Pastorekova S. , Friess H. , Buchler P.
Br. J. Cancer103:1571-1579(2010) [PubMed] [Europe PMC] [Abstract]

"Prolyl hydroxylase domain protein 3 targets Pax2 for destruction."
Yan B. , Jiao S. , Zhang H.S. , Lv D.D. , Xue J. , Fan L. , Wu G.H. , Fang J.
Biochem. Biophys. Res. Commun.409:315-320(2011) [PubMed] [Europe PMC] [Abstract]

"Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites."
Pappalardi M.B. , McNulty D.E. , Martin J.D. , Fisher K.E. , Jiang Y. , Burns M.C. , Zhao H. , Ho T. , Sweitzer S. , Schwartz B. , Annan R.S. , Copeland R.A. , Tummino P.J. , Luo L.
Biochem. J.436:363-369(2011) [PubMed] [Europe PMC] [Abstract]

"Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1."
Luo W. , Hu H. , Chang R. , Zhong J. , Knabel M. , O'Meally R. , Cole R.N. , Pandey A. , Semenza G.L.
Cell145:732-744(2011) [PubMed] [Europe PMC] [Abstract]

"The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase."
Chen N. , Rinner O. , Czernik D. , Nytko K.J. , Zheng D. , Stiehl D.P. , Zamboni N. , Gstaiger M. , Frei C.
Cell Res.21:983-986(2011) [PubMed] [Europe PMC] [Abstract]

"Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice."
Walmsley S.R. , Chilvers E.R. , Thompson A.A. , Vaughan K. , Marriott H.M. , Parker L.C. , Shaw G. , Parmar S. , Schneider M. , Sabroe I. , Dockrell D.H. , Milo M. , Taylor C.T. , Johnson R.S. , Pugh C.W. , Ratcliffe P.J. , Maxwell P.H. , Carmeliet P. , Whyte M.K. more...
J. Clin. Invest.121:1053-1063(2011) [PubMed] [Europe PMC] [Abstract]

"Effects of polynitrogen compounds on the activity of recombinant human HIF-1alpha prolyl hydroxylase 3 in E. coli."
Geng Z. , Zhu J. , Cao J. , Geng J. , Song X. , Zhang Z. , Bian N. , Wang Z.
J. Inorg. Biochem.105:391-399(2011) [PubMed] [Europe PMC] [Abstract]

"PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response."
Xie L. , Pi X. , Mishra A. , Fong G. , Peng J. , Patterson C.
J. Clin. Invest.122:2827-2836(2012) [PubMed] [Europe PMC] [Abstract]

"The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity."
Foxler D.E. , Bridge K.S. , James V. , Webb T.M. , Mee M. , Wong S.C. , Feng Y. , Constantin-Teodosiu D. , Petursdottir T.E. , Bjornsson J. , Ingvarsson S. , Ratcliffe P.J. , Longmore G.D. , Sharp T.V.
Nat. Cell Biol.14:201-208(2012) [PubMed] [Europe PMC] [Abstract]