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Index > Protein center > Egln3(Gene name) > Mouse
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  • Egln3 (Gene name),
  • Egl nine homolog 3 (Protein name ),  EGLN3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Egln3;
    Protein name:
    Egl nine homolog 3;
    Alternative:
    SM-20(PHD3);Hypoxia-inducible factor prolyl hydroxylase 3(HIF-PH3;HIF-prolyl hydroxylase 3;HPH-3);SM-20;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with MORG1.
    Function:
    Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    239
    Sequence:
    50:
    MPLGHIMRLD | LEKIALEYIV | PCLHEVGFCY | LDNFLGEVVG | DCVLERVKQL | 
    100:
    HYNGALRDGQ | LAGPRAGVSK | RHLRGDQITW | IGGNEEGCEA | INFLLSLIDR | 
    150:
    LVLYCGSRLG | KYYVKERSKA | MVACYPGNGT | GYVRHVDNPN | GDGRCITCIY | 
    200:
    YLNKNWDAKL | HGGVLRIFPE | GKSFVADVEP | IFDRLLFFWS | DRRNPHEVQP | 
    239:
    SYATRYAMTV | WYFDAEERAE | AKKKFRNLTR | KTESALAKD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Egl nine homolog 3
    ELISA Kit for Mouse Egl nine homolog 3
    ELISA Kit for Mouse Egl nine homolog 3
    CLIA Kit for Mouse Egl nine homolog 3
    CLIA Kit for Mouse Egl nine homolog 3
    CLIA Kit for Mouse Egl nine homolog 3
    Polyclonal Antibody for Mouse Egl nine homolog 3
    Polyclonal Antibody for Mouse Egl nine homolog 3
    Polyclonal Antibody for Mouse Egl nine homolog 3
    Monoclonal Antibody for Mouse Egl nine homolog 3
    Monoclonal Antibody for Mouse Egl nine homolog 3
    Monoclonal Antibody for Mouse Egl nine homolog 3
    Protein for Mouse Egl nine homolog 3
    Protein for Mouse Egl nine homolog 3
    Protein for Mouse Egl nine homolog 3

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation."
      Moschella M.C. , Menzies K. , Tsao L. , Lieb M.A. , Kohtz J.D. , Kohtz D.S. , Taubman M.B.
      Gene Expr.8:59-66(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE
      tissue: Embryo.
    2. 2.
      "Characterization and comparative analysis of the EGLN gene family."
      Taylor M.S.
      Gene275:125-132(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Dendritic cell.
      tissue: Lung.
      tissue: Retina.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N-3.
      strain: NMRI.
      tissue: Mammary gland.
    5. 5.
      "Mammalian EGLN genes have distinct patterns of mRNA expression and regulation."
      Lieb M.E. , Menzies K. , Moschella M.C. , Ni R. , Taubman M.B.
      Biochem. Cell Biol.80:421-426(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    7. 7.
      "A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo."
      Minamishima Y.A. , Moslehi J. , Padera R.F. , Bronson R.T. , Liao R. , Kaelin W.G. Jr.
      Mol. Cell. Biol.29:5729-5741(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    8. 8.
      "Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL."
      Xie L. , Xiao K. , Whalen E.J. , Forrester M.T. , Freeman R.S. , Fong G. , Gygi S.P. , Lefkowitz R.J. , Stamler J.S.
      Sci. Signal.2:RA33-RA33(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
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