Egln3 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comEgln3 ELISA Kit for Rat(Rattus norvegicus)

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Egln3 (Gene name),

Egl nine homolog 3, mitochondrial (Protein name ), EGLN3_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Egln3(Sm20);

Protein name:

Egl nine homolog 3, mitochondrial;

Alternative:

SM-20(PHD3);Hypoxia-inducible factor prolyl hydroxylase 3(HIF-PH3;HIF-prolyl hydroxylase 3;HPH-3);SM-20;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with MORG1.

Function:

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism.

Subcellular Location:

Mitochondrion Cytoplasm

Protein Attributes:

Sequence length:

355

Sequence:

50:

100:

150:

200:

250:

300:

350:

355:

ALAKD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q62630

Pfam:

PF03171

UniGene:

Rn.10994

KEGG:

rno:54702

String:

Q62630

STRING:

10116.ENSRNOP00000007219

Uniprot:

Q62630

FOR

ELISA Kit for Rat Egl nine homolog 3, mitochondrial

CLIA Kit for Rat Egl nine homolog 3, mitochondrial

Polyclonal Antibody for Rat Egl nine homolog 3, mitochondrial

Monoclonal Antibody for Rat Egl nine homolog 3, mitochondrial

Protein for Rat Egl nine homolog 3, mitochondrial

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of a novel growth factor-responsive gene in vascular smooth muscle cells."
Wax S.D. , Rosenfield C.L. , Taubman M.B.
J. Biol. Chem.269:13041-13047(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION
strain: Sprague-Dawley.
tissue: Aortic smooth muscle.
2.

"Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons."
Lipscomb E.A. , Sarmiere P.D. , Crowder R.J. , Freeman R.S.
J. Neurochem.73:429-432(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
3.

"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation."
Epstein A.C.R. , Gleadle J.M. , McNeill L.A. , Hewitson K.S. , O'Rourke J. , Mole D.R. , Mukherji M. , Metzen E. , Wilson M.I. , Dhanda A. , Tian Y.M. , Masson N. , Hamilton D.L. , Jaakkola P. , Barstead R. , Hodgkin J. , Maxwell P.H. , Pugh C.W. , more...
Cell107:43-54(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons."
Lipscomb E.A. , Sarmiere P.D. , Freeman R.S.
J. Biol. Chem.276:5085-5092(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
5.

"Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells."
Menzies K. , Liu B. , Kim W.J. , Moschella M.C. , Taubman M.B.
Biochem. Biophys. Res. Commun.317:801-810(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF INITIATION SITE;INDUCTION;TISSUE SPECIFICITY
6.

"The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)."
Hopfer U. , Hopfer H. , Jablonski K. , Stahl R.A.K. , Wolf G.
J. Biol. Chem.281:8645-8655(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WDR83;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.

"HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation."
Willam C. , Maxwell P.H. , Nichols L. , Lygate C. , Tian Y.M. , Bernhardt W. , Wiesener M. , Ratcliffe P.J. , Eckardt K.U. , Pugh C.W.
J. Mol. Cell. Cardiol.41:68-77(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INDUCTION
8.

"Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells."
Liu Y. , Huo Z. , Yan B. , Lin X. , Zhou Z.N. , Liang X. , Zhu W. , Liang D. , Li L. , Liu Y. , Zhao H. , Sun Y. , Chen Y.H.
Biochem. Biophys. Res. Commun.401:231-237(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL2;FUNCTION

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