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Index > Protein center > Egr2(Gene name) > Mouse
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  • Egr2 (Gene name),
  • Early growth response protein 2 (Protein name ),  EGR2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Egr2(Egr-2;Krox-20;Zfp-25);
    Protein name:
    Early growth response protein 2(EGR-2);
    Alternative:
    Zinc finger protein Krox-20;Zinc finger protein Krox-20(EGR-2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with HCFC1 (By similarity). Interacts with WWP2. Interacts with CITED1. Interacts (via phosphorylated form) with SFN.
    Function:
    Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    470
    Sequence:
    50:
    MMTAKAVDKI | PVTLSGFMHQ | LPDSLYPVED | LAASSVTIFP | NGELGGPFDQ | 
    100:
    MNGVAGDGMI | NIDMTGEKRP | LDLPYPSSFA | PISAPRNQTF | TYMGKFSIDP | 
    150:
    QYPGASCYPE | GIINIVSAGI | LQGVTPPAST | TASSSVTSAS | PNPLATGPLG | 
    200:
    VCTMSQTQPE | LDHLYSPPPP | PPPYSGCTGD | LYQDPSAFLS | PPSTTSTSSL | 
    250:
    AYQPPPSYPS | PKPAMDPGLI | PMIPDYPGFF | PSPCQRDPHG | AAGPDRKPFP | 
    300:
    CPLDSLRVPP | PLTPLSTIRN | FTLGGPGAGV | TGPGASGGGE | GPRLPGSGSA | 
    350:
    AVTATPYNPH | HLPLRPILRP | RKYPNRPSKT | PVHERPYPCP | AEGCDRRFSR | 
    400:
    SDELTRHIRI | HTGHKPFQCR | ICMRNFSRSD | HLTTHIRTHT | GEKPFACDYC | 
    450:
    GRKFARSDER | KRHTKIHLRQ | KERKSSAPSA | PPSAQSSASG | PGGSQAGGSL | 
    470:
    CGNSAIGGPL | ASCTSRTRTP | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse EGR-2
    Cat.:
    E9221r
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse EGR-2
    Cat.:
    E9221p
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse EGR-2
    Cat.:
    E9221m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse EGR-2
    Cat.:
    E9221h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse EGR-2
    Cat.:
    U9221m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse EGR-2
    Cat.:
    U9221h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse EGR-2
    Cat.:
    U9221p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse EGR-2
    Cat.:
    U9221r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse EGR-2
    Cat.:
    P9221Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse EGR-2
    Polyclonal Antibody for Mouse EGR-2
    Cat.:
    P9221Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse EGR-2
    Cat.:
    P9221Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse EGR-2
    Monoclonal Antibody for Mouse EGR-2
    Monoclonal Antibody for Mouse EGR-2
    Monoclonal Antibody for Mouse EGR-2
    Protein for Mouse EGR-2
    Protein for Mouse EGR-2
    Protein for Mouse EGR-2
    Protein for Mouse EGR-2

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    Linearity
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    References
    1. 1.
      "Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos."
      Chavrier P. , Janssen-Timmen U. , Mattei M.-G. , Zerial M. , Bravo R. , Charnay P.
      Mol. Cell. Biol.9:787-797(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT)
    2. 2.
      "A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells."
      Chavrier P. , Zerial M. , Lemaire P. , Almendral J. , Bravo R. , Charnay P.
      EMBO J.7:29-35(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      strain: FVB/N.
      tissue: Mammary gland.
    4. 4.
      "Characterization of a mouse multigene family that encodes zinc finger structures."
      Chavrier P. , Lemaire P. , Revelant O. , Bravo R. , Charnay P.
      Mol. Cell. Biol.8:1319-1326(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 339-417
    5. 5.
      "The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene."
      Chavrier P. , Vesque C. , Galliot B. , Vigneron M. , Dolle P. , Duboule D. , Charnay P.
      EMBO J.9:1209-1218(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Krox-20: a candidate gene for the regulation of pattern formation in the hindbrain."
      Gilardi P. , Schneider-Maunoury S. , Charnay P.
      Biochimie73:85-91(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Mapping functional regions of the segment-specific transcription factor Krox-20."
      Vesque C. , Charnay P.
      Nucleic Acids Res.20:2485-2492(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAINS
    8. 8.
      "An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer."
      Dillon R.L. , Brown S.T. , Ling C. , Shioda T. , Muller W.J.
      Mol. Cell. Biol.27:8648-8657(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CITED1 AND SFN;MUTAGENESIS OF SER-377;DNA-BINDING;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    9. 9.
      "The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination."
      Chen A. , Gao B. , Zhang J. , McEwen T. , Ye S.Q. , Zhang D. , Fang D.
      Mol. Cell. Biol.29:5348-5356(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH WWP2;MUTAGENESIS OF TYR-174 AND TYR-208
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