Gene name:
EHMT1(EUHMTASE1;GLP;KIAA1876;KMT1D);
Protein name:
Histone-lysine N-methyltransferase EHMT1;
Alternative:
G9a-like protein 1(GLP;GLP1);Euchromatic histone-lysine N-methyltransferase 1(Eu-HMTase1);Lysine N-methyltransferase 1D;Histone H3-K9 methyltransferase 5(H3-K9-HMTase 5);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer; heterodimerizes with EHMT2/G9a. Interacts with WIZ and EHMT2. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts (via ANK repeats) with RELA (when monomethylated at 'Lys-310').
Function:
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.
Subcellular Location:
Nucleus
Chromosome
Associates with euchromatic regions.
Protein Attributes:
50:
MAAADAEAVP | ARGEPQQDCC | VKTELLGEET | PMAADEGSAE | KQAGEAHMAA |
100:
DGETNGSCEN | SDASSHANAA | KHTQDSARVN | PQDGTNTLTR | IAENGVSERD |
150:
SEAAKQNHVT | ADDFVQTSVI | GSNGYILNKP | ALQAQPLRTT | STLASSLPGH |
200:
AAKTLPGGAG | KGRTPSAFPQ | TPAAPPATLG | EGSADTEDRK | LPAPGADVKV |
250:
HRARKTMPKS | VVGLHAASKD | PREVREARDH | KEPKEEINKN | ISDFGRQQLL |
300:
PPFPSLHQSL | PQNQCYMATT | KSQTACLPFV | LAAAVSRKKK | RRMGTYSLVP |
350:
KKKTKVLKQR | TVIEMFKSIT | HSTVGSKGEK | DLGASSLHVN | GESLEMDSDE |
400:
DDSEELEEDD | GHGAEQAAAF | PTEDSRTSKE | SMSEADRAQK | MDGESEEEQE |
450:
SVDTGEEEEG | GDESDLSSES | SIKKKFLKRK | GKTDSPWIKP | ARKRRRRSRK |
500:
KPSGALGSES | YKSSAGSAEQ | TAPGDSTGYM | EVSLDSLDLR | VKGILSSQAE |
550:
GLANGPDVLE | TDGLQEVPLC | SCRMETPKSR | EITTLANNQC | MATESVDHEL |
600:
GRCTNSVVKY | ELMRPSNKAP | LLVLCEDHRG | RMVKHQCCPG | CGYFCTAGNF |
650:
MECQPESSIS | HRFHKDCASR | VNNASYCPHC | GEESSKAKEV | TIAKADTTST |
700:
VTPVPGQEKG | SALEGRADTT | TGSAAGPPLS | EDDKLQGAAS | HVPEGFDPTG |
750:
PAGLGRPTPG | LSQGPGKETL | ESALIALDSE | KPKKLRFHPK | QLYFSARQGE |
800:
LQKVLLMLVD | GIDPNFKMEH | QNKRSPLHAA | AEAGHVDICH | MLVQAGANID |
850:
TCSEDQRTPL | MEAAENNHLE | AVKYLIKAGA | LVDPKDAEGS | TCLHLAAKKG |
900:
HYEVVQYLLS | NGQMDVNCQD | DGGWTPMIWA | TEYKHVDLVK | LLLSKGSDIN |
950:
IRDNEENICL | HWAAFSGCVD | IAEILLAAKC | DLHAVNIHGD | SPLHIAAREN |
1000:
RYDCVVLFLS | RDSDVTLKNK | EGETPLQCAS | LNSQVWSALQ | MSKALQDSAP |
1050:
DRPSPVERIV | SRDIARGYER | IPIPCVNAVD | SEPCPSNYKY | VSQNCVTSPM |
1100:
NIDRNITHLQ | YCVCIDDCSS | SNCMCGQLSM | RCWYDKDGRL | LPEFNMAEPP |
1150:
LIFECNHACS | CWRNCRNRVV | QNGLRARLQL | YRTRDMGWGV | RSLQDIPPGT |
1200:
FVCEYVGELI | SDSEADVREE | DSYLFDLDNK | DGEVYCIDAR | FYGNVSRFIN |
1250:
HHCEPNLVPV | RVFMAHQDLR | FPRIAFFSTR | LIEAGEQLGF | DYGERFWDIK |
1298:
GKLFSCRCGS | PKCRHSSAAL | AQRQASAAQE | AQEDGLPDTS | SAAAADPL

Vaild Sequence:
Related Databases
Uniprot: