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Index > Protein center > EHMT1(Gene name) > Human
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  • EHMT1 (Gene name),
  • Histone-lysine N-methyltransferase EHMT1 (Protein name ),  EHMT1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EHMT1(EUHMTASE1;GLP;KIAA1876;KMT1D);
    Protein name:
    Histone-lysine N-methyltransferase EHMT1;
    Alternative:
    G9a-like protein 1(GLP;GLP1);Euchromatic histone-lysine N-methyltransferase 1(Eu-HMTase1);Lysine N-methyltransferase 1D;Histone H3-K9 methyltransferase 5(H3-K9-HMTase 5);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer; heterodimerizes with EHMT2/G9a. Interacts with WIZ and EHMT2. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts (via ANK repeats) with RELA (when monomethylated at 'Lys-310').
    Function:
    Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.
    Subcellular Location:
    Nucleus Chromosome Associates with euchromatic regions.
    Protein Attributes:
    Sequence length:
    1298
    Sequence:
    50:
    MAAADAEAVP | ARGEPQQDCC | VKTELLGEET | PMAADEGSAE | KQAGEAHMAA | 
    100:
    DGETNGSCEN | SDASSHANAA | KHTQDSARVN | PQDGTNTLTR | IAENGVSERD | 
    150:
    SEAAKQNHVT | ADDFVQTSVI | GSNGYILNKP | ALQAQPLRTT | STLASSLPGH | 
    200:
    AAKTLPGGAG | KGRTPSAFPQ | TPAAPPATLG | EGSADTEDRK | LPAPGADVKV | 
    250:
    HRARKTMPKS | VVGLHAASKD | PREVREARDH | KEPKEEINKN | ISDFGRQQLL | 
    300:
    PPFPSLHQSL | PQNQCYMATT | KSQTACLPFV | LAAAVSRKKK | RRMGTYSLVP | 
    350:
    KKKTKVLKQR | TVIEMFKSIT | HSTVGSKGEK | DLGASSLHVN | GESLEMDSDE | 
    400:
    DDSEELEEDD | GHGAEQAAAF | PTEDSRTSKE | SMSEADRAQK | MDGESEEEQE | 
    450:
    SVDTGEEEEG | GDESDLSSES | SIKKKFLKRK | GKTDSPWIKP | ARKRRRRSRK | 
    500:
    KPSGALGSES | YKSSAGSAEQ | TAPGDSTGYM | EVSLDSLDLR | VKGILSSQAE | 
    550:
    GLANGPDVLE | TDGLQEVPLC | SCRMETPKSR | EITTLANNQC | MATESVDHEL | 
    600:
    GRCTNSVVKY | ELMRPSNKAP | LLVLCEDHRG | RMVKHQCCPG | CGYFCTAGNF | 
    650:
    MECQPESSIS | HRFHKDCASR | VNNASYCPHC | GEESSKAKEV | TIAKADTTST | 
    700:
    VTPVPGQEKG | SALEGRADTT | TGSAAGPPLS | EDDKLQGAAS | HVPEGFDPTG | 
    750:
    PAGLGRPTPG | LSQGPGKETL | ESALIALDSE | KPKKLRFHPK | QLYFSARQGE | 
    800:
    LQKVLLMLVD | GIDPNFKMEH | QNKRSPLHAA | AEAGHVDICH | MLVQAGANID | 
    850:
    TCSEDQRTPL | MEAAENNHLE | AVKYLIKAGA | LVDPKDAEGS | TCLHLAAKKG | 
    900:
    HYEVVQYLLS | NGQMDVNCQD | DGGWTPMIWA | TEYKHVDLVK | LLLSKGSDIN | 
    950:
    IRDNEENICL | HWAAFSGCVD | IAEILLAAKC | DLHAVNIHGD | SPLHIAAREN | 
    1000:
    RYDCVVLFLS | RDSDVTLKNK | EGETPLQCAS | LNSQVWSALQ | MSKALQDSAP | 
    1050:
    DRPSPVERIV | SRDIARGYER | IPIPCVNAVD | SEPCPSNYKY | VSQNCVTSPM | 
    1100:
    NIDRNITHLQ | YCVCIDDCSS | SNCMCGQLSM | RCWYDKDGRL | LPEFNMAEPP | 
    1150:
    LIFECNHACS | CWRNCRNRVV | QNGLRARLQL | YRTRDMGWGV | RSLQDIPPGT | 
    1200:
    FVCEYVGELI | SDSEADVREE | DSYLFDLDNK | DGEVYCIDAR | FYGNVSRFIN | 
    1250:
    HHCEPNLVPV | RVFMAHQDLR | FPRIAFFSTR | LIEAGEQLGF | DYGERFWDIK | 
    1298:
    GKLFSCRCGS | PKCRHSSAAL | AQRQASAAQE | AQEDGLPDTS | SAAAADPL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    Pfam:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Histone-lysine N-methyltransferase EHMT1
    ELISA Kit for Human Histone-lysine N-methyltransferase EHMT1
    CLIA Kit for Human Histone-lysine N-methyltransferase EHMT1
    CLIA Kit for Human Histone-lysine N-methyltransferase EHMT1
    Polyclonal Antibody for Human Histone-lysine N-methyltransferase EHMT1
    Polyclonal Antibody for Human Histone-lysine N-methyltransferase EHMT1
    Monoclonal Antibody for Human Histone-lysine N-methyltransferase EHMT1
    Monoclonal Antibody for Human Histone-lysine N-methyltransferase EHMT1
    Protein for Human Histone-lysine N-methyltransferase EHMT1
    Protein for Human Histone-lysine N-methyltransferase EHMT1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Teratocarcinoma.
    2. 2.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 583-1298 (ISOFORM 1)
      tissue: Brain.
      tissue: Testis.
    4. 4.
      "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells."
      Ogawa H. , Ishiguro K. , Gaubatz S. , Livingston D.M. , Nakatani Y.
      Science296:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-1298 (ISOFORM 1);FUNCTION;CATALYTIC ACTIVITY;IDENTIFICATION IN COMPLEX WITH E2F6; TFDP1; MAX; MGA; BAT8; CBX3; RING1; RNF2; MBLR; L3MBTL2 AND YAF2
      tissue: Cervix carcinoma.
    5. 5.
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      Submitted (1999-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 382-1298 (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Nakayama M. , Nakajima D. , Kikuno R. , Ohara O.
      DNA Res.8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 382-1298 (ISOFORM 3);TISSUE SPECIFICITY
      tissue: Brain.
    7. 7.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1089-1298 (ISOFORM 1)
      tissue: Lymph node.
    9. 9.
      "Loss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome."
      Kleefstra T. , Brunner H.G. , Amiel J. , Oudakker A.R. , Nillesen W.M. , Magee A. , Genevieve D. , Cormier-Daire V. , van Esch H. , Fryns J.-P. , Hamel B.C.J. , Sistermans E.A. , de Vries B.B.A. , van Bokhoven H.
      Am. J. Hum. Genet.79:370-377(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN KLESTS
    10. 10.
      "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP."
      Ueda J. , Tachibana M. , Ikura T. , Shinkai Y.
      J. Biol. Chem.281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WIZ AND EHMT2
    11. 11.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    12. 12.
      "CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation."
      Mulligan P. , Westbrook T.F. , Ottinger M. , Pavlova N. , Chang B. , Macia E. , Shi Y.J. , Barretina J. , Liu J. , Howley P.M. , Elledge S.J. , Shi Y.
      Mol. Cell32:718-726(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDYL AND REST;IDENTIFICATION IN A COMPLEX WITH REST; CDYL; SETB1; EHMT2 AND WIZ
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion."
      Kokura K. , Sun L. , Bedford M.T. , Fang J.
      EMBO J.29:3673-3687(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MPHOSPH8
    15. 15.
      "G9a and Glp methylate lysine 373 in the tumor suppressor p53."
      Huang J. , Dorsey J. , Chuikov S. , Perez-Burgos L. , Zhang X. , Jenuwein T. , Reinberg D. , Berger S.L.
      J. Biol. Chem.285:9636-9641(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP53
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "The ankyrin repeats of G9a and GLP histone methyltransferases are mono-and dimethyllysine binding modules."
      Collins R.E. , Northrop J.P. , Horton J.R. , Lee D.Y. , Zhang X. , Stallcup M.R. , Cheng X.
      Nat. Struct. Mol. Biol.15:245-250(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.99 ANGSTROMS) OF 765-999 IN COMPLEX WITH HISTONE H3;DOMAIN ANK REPEATS;MUTAGENESIS OF GLU-905
    20. 20.
      "Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases."
      Chang Y. , Ganesh T. , Horton J.R. , Spannhoff A. , Liu J. , Sun A. , Zhang X. , Bedford M.T. , Shinkai Y. , Snyder J.P. , Cheng X.
      J. Mol. Biol.400:1-7(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 982-1266 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE; ZINC ION AND E72 INHIBITOR;ENZYME REGULATION
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 982-1266 IN COMPLEX WITH HISTONE H3; S-ADENOSYL-L-HOMOCYSTEINE AND ZINC IONS
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-43 AND PHE-1173
    23. 23.
      "Further clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotype."
      Kleefstra T. , van Zelst-Stams W.A. , Nillesen W.M. , Cormier-Daire V. , Houge G. , Foulds N. , van Dooren M. , Willemsen M.H. , Pfundt R. , Turner A. , Wilson M. , McGaughran J. , Rauch A. , Zenker M. , Adam M.P. , Innes M. , Davies C. , Lopez A.G. , more...
      J. Med. Genet.46:598-606(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT KLESTS TYR-1075
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