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Index > Protein center > EIF2B4(Gene name) > Human
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  • EIF2B4 (Gene name),
  • Translation initiation factor eIF-2B subunit delta (Protein name ),  EI2BD_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EIF2B4(EIF2BD);
    Protein name:
    Translation initiation factor eIF-2B subunit delta;
    Alternative:
    eIF-2B GDP-GTP exchange factor subunit delta;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
    Function:
    Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    523
    Sequence:
    50:
    MAAVAVAVRE | DSGSGMKAEL | PPGPGAVGRE | MTKEEKLQLR | KEKKQQKKKR | 
    100:
    KEEKGAEPET | GSAVSAAQCQ | VGPTRELPES | GIQLGTPREK | VPAGRSKAEL | 
    150:
    RAERRAKQEA | ERALKQARKG | EQGGPPPKAS | PSTAGETPSG | VKRLPEYPQV | 
    200:
    DDLLLRRLVK | KPERQQVPTR | KDYGSKVSLF | SHLPQYSRQN | SLTQFMSIPS | 
    250:
    SVIHPAMVRL | GLQYSQGLVS | GSNARCIALL | RALQQVIQDY | TTPPNEELSR | 
    300:
    DLVNKLKPYM | SFLTQCRPLS | ASMHNAIKFL | NKEITSVGSS | KREEEAKSEL | 
    350:
    RAAIDRYVQE | KIVLAAQAIS | RFAYQKISNG | DVILVYGCSS | LVSRILQEAW | 
    400:
    TEGRRFRVVV | VDSRPWLEGR | HTLRSLVHAG | VPASYLLIPA | ASYVLPEVSK | 
    450:
    VLLGAHALLA | NGSVMSRVGT | AQLALVARAH | NVPVLVCCET | YKFCERVQTD | 
    500:
    AFVSNELDDP | DDLQCKRGEH | VALANWQNHA | SLRLLNLVYD | VTPPELVDLV | 
    523:
    ITELGMIPCS | SVPVVLRVKS | SDQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Translation initiation factor eIF-2B subunit delta
    ELISA Kit for Human Translation initiation factor eIF-2B subunit delta
    ELISA Kit for Human Translation initiation factor eIF-2B subunit delta
    ELISA Kit for Human Translation initiation factor eIF-2B subunit delta
    ELISA Kit for Human Translation initiation factor eIF-2B subunit delta
    CLIA Kit for Human Translation initiation factor eIF-2B subunit delta
    CLIA Kit for Human Translation initiation factor eIF-2B subunit delta
    CLIA Kit for Human Translation initiation factor eIF-2B subunit delta
    CLIA Kit for Human Translation initiation factor eIF-2B subunit delta
    CLIA Kit for Human Translation initiation factor eIF-2B subunit delta
    Polyclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Polyclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Polyclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Polyclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Polyclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Monoclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Monoclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Monoclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Monoclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Monoclonal Antibody for Human Translation initiation factor eIF-2B subunit delta
    Protein for Human Translation initiation factor eIF-2B subunit delta
    Protein for Human Translation initiation factor eIF-2B subunit delta
    Protein for Human Translation initiation factor eIF-2B subunit delta
    Protein for Human Translation initiation factor eIF-2B subunit delta
    Protein for Human Translation initiation factor eIF-2B subunit delta

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Adrenal gland.
    2. 2.
      "cDNA cloning, genomic organization and chromosomal localization of the human eIF2B delta subunit."
      Wightman P.J. , Bonthron D.T.
      Submitted (1998-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3)
    3. 3.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
      tissue: Testis.
    6. 6.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-86;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-86;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 10.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-86;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    13. 13.
      "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter."
      van der Knaap M.S. , Leegwater P.A.J. , Koenst A.A.M. , Visser A. , Naidu S. , Oudejans C.B.M. , Schutgens R.B.H. , Pronk J.C.
      Ann. Neurol.51:264-270(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VWM VAL-228; GLN-357 AND CYS-374;VARIANT GLY-306
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VWM ARG-465 AND HIS-489
    15. 15.
      "Identification of ten novel mutations in patients with eIF2B-related disorders."
      Ohlenbusch A. , Henneke M. , Brockmann K. , Goerg M. , Hanefeld F. , Kohlschutter A. , Gartner J.
      Hum. Mutat.25:411-411(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VWM GLN-209; ARG-269 AND CYS-374
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