Gene name:
EIF2D (HCA56;LGTN) ;
Protein name:
Eukaryotic translation initiation factor 2D (eIF2d) ;
Alternative:
Ligatin ;Hepatocellular carcinoma-associated antigen 56 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MFAKAFRVKS | NTAIKGSDRR | KLRADVTTAF | PTLGTDQVSE | LVPGKEELNI |
100:
VKLYAHKGDA | VTVYVSGGNP | ILFELEKNLY | PTVYTLWSYP | DLLPTFTTWP |
150:
LVLEKLVGGA | DLMLPGLVMP | PAGLPQVQKG | DLCAISLVGN | RAPVAIGVAA |
200:
MSTAEMLTSG | LKGRGFSVLH | TYQDHLWRSG | NKSSPPSIAP | LALDSADLSE |
250:
EKGSVQMDST | LQGDMRHMTL | EGEEENGEVH | QAREDKSLSE | APEDTSTRGL |
300:
NQDSTDSKTL | QEQMDELLQQ | CFLHALKCRV | KKADLPLLTS | TFLGSHMFSC |
350:
CPEGRQLDIK | KSSYKKLSKF | LQQMQQEQII | QVKELSKGVE | SIVAVDWKHP |
400:
RITSFVIPEP | SPTSQTIQEG | SREQPYHPPD | IKPLYCVPAS | MTLLFQESGH |
450:
KKGSFLEGSE | VRTIVINYAK | KNDLVDADNK | NLVRLDPILC | DCILEKNEQH |
500:
TVMKLPWDSL | LTRCLEKLQP | AYQVTLPGQE | PIVKKGRICP | IDITLAQRAS |
550:
NKKVTVVRNL | EAYGLDPYSV | AAILQQRCQA | STTVNPAPGA | KDSLQVQIQG |
584:
NQVHHLGWLL | LEEYQLPRKH | IQGLEKALKP | GKKK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Mouse
Human
Rabbit
ELISA Kit for Human eIF2d
ELISA Kit for Human eIF2d
ELISA Kit for Human eIF2d
ELISA Kit for Human eIF2d
ELISA Kit for Human eIF2d
Polyclonal Antibody for Human eIF2d
Polyclonal Antibody for Human eIF2d
Polyclonal Antibody for Human eIF2d
Polyclonal Antibody for Human eIF2d
Polyclonal Antibody for Human eIF2d
Monoclonal Antibody for Human eIF2d
Monoclonal Antibody for Human eIF2d
Monoclonal Antibody for Human eIF2d
Monoclonal Antibody for Human eIF2d
Monoclonal Antibody for Human eIF2d
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SUBCELLULAR LOCATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue :
Hepatoma .
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more...
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Placenta .
4.
"The DNA sequence and biological annotation of human chromosome 1."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Cervix .
tissue :
Lymph .
tissue :
Testis .
7.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
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Rosenfelder H.
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Duda A.
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Michel G.
,
Wedler H.
,
Koehrer K.
,
Ottenwaelder B.
,
Poustka A.
,
Wiemann S.
,
Schupp I.
more...
BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 196-584 (ISOFORM 1)
tissue :
Testis .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 234-308
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.
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Cited for : FUNCTION
12.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]