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Index > Protein center > EIF2D(Gene name) > Human
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  • EIF2D (Gene name),
  • Eukaryotic translation initiation factor 2D (Protein name ),  EIF2D_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EIF2D(HCA56;LGTN);
    Protein name:
    Eukaryotic translation initiation factor 2D(eIF2d);
    Alternative:
    Ligatin;Hepatocellular carcinoma-associated antigen 56;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    584
    Sequence:
    50:
    MFAKAFRVKS | NTAIKGSDRR | KLRADVTTAF | PTLGTDQVSE | LVPGKEELNI | 
    100:
    VKLYAHKGDA | VTVYVSGGNP | ILFELEKNLY | PTVYTLWSYP | DLLPTFTTWP | 
    150:
    LVLEKLVGGA | DLMLPGLVMP | PAGLPQVQKG | DLCAISLVGN | RAPVAIGVAA | 
    200:
    MSTAEMLTSG | LKGRGFSVLH | TYQDHLWRSG | NKSSPPSIAP | LALDSADLSE | 
    250:
    EKGSVQMDST | LQGDMRHMTL | EGEEENGEVH | QAREDKSLSE | APEDTSTRGL | 
    300:
    NQDSTDSKTL | QEQMDELLQQ | CFLHALKCRV | KKADLPLLTS | TFLGSHMFSC | 
    350:
    CPEGRQLDIK | KSSYKKLSKF | LQQMQQEQII | QVKELSKGVE | SIVAVDWKHP | 
    400:
    RITSFVIPEP | SPTSQTIQEG | SREQPYHPPD | IKPLYCVPAS | MTLLFQESGH | 
    450:
    KKGSFLEGSE | VRTIVINYAK | KNDLVDADNK | NLVRLDPILC | DCILEKNEQH | 
    500:
    TVMKLPWDSL | LTRCLEKLQP | AYQVTLPGQE | PIVKKGRICP | IDITLAQRAS | 
    550:
    NKKVTVVRNL | EAYGLDPYSV | AAILQQRCQA | STTVNPAPGA | KDSLQVQIQG | 
    584:
    NQVHHLGWLL | LEEYQLPRKH | IQGLEKALKP | GKKK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    KEGG:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human eIF2d
    ELISA Kit for Human eIF2d
    ELISA Kit for Human eIF2d
    ELISA Kit for Human eIF2d
    ELISA Kit for Human eIF2d
    CLIA Kit for Human eIF2d
    CLIA Kit for Human eIF2d
    CLIA Kit for Human eIF2d
    CLIA Kit for Human eIF2d
    CLIA Kit for Human eIF2d
    Polyclonal Antibody for Human eIF2d
    Polyclonal Antibody for Human eIF2d
    Polyclonal Antibody for Human eIF2d
    Polyclonal Antibody for Human eIF2d
    Polyclonal Antibody for Human eIF2d
    Monoclonal Antibody for Human eIF2d
    Monoclonal Antibody for Human eIF2d
    Monoclonal Antibody for Human eIF2d
    Monoclonal Antibody for Human eIF2d
    Monoclonal Antibody for Human eIF2d
    Protein for Human eIF2d
    Protein for Human eIF2d
    Protein for Human eIF2d
    Protein for Human eIF2d
    Protein for Human eIF2d

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor."
      Dmitriev S.E. , Terenin I.M. , Andreev D.E. , Ivanov P.A. , Dunaevsky J.E. , Merrick W.C. , Shatsky I.N.
      J. Biol. Chem.285:26779-26787(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SUBCELLULAR LOCATION
    2. 2.
      "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
      Wang Y. , Han K.-J. , Pang X.-W. , Vaughan H.A. , Qu W. , Dong X.-Y. , Peng J.-R. , Zhao H.-T. , Rui J.-A. , Leng X.-S. , Cebon J. , Burgess A.W. , Chen W.-F.
      J. Immunol.169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Hepatoma.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cervix.
      tissue: Lymph.
      tissue: Testis.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 196-584 (ISOFORM 1)
      tissue: Testis.
    8. 8.
      "Molecular cloning of the cDNA for ligatin."
      Jakoi E.R. , Brown A.L. , Ho Y.S. , Snyderman R.
      J. Cell Sci.93:227-232(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 234-308
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling."
      Skabkin M.A. , Skabkina O.V. , Dhote V. , Komar A.A. , Hellen C.U. , Pestova T.V.
      Genes Dev.24:1787-1801(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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