Gene name:
Eif3c (Eif3s8) ;
Protein name:
Eukaryotic translation initiation factor 3 subunit C (eIF3c) ;
Alternative:
eIF3 p110 ;Eukaryotic translation initiation factor 3 subunit 8 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSRFFTTGSD | SESESSLSGE | ELVTKPVSGN | YGKQPLLLSE | DEEDTKRVVR |
100:
SAKDKRFEEL | TNLIRTIRNA | MKIRDVTKCL | EEFELLGKAY | GKAKSIVDKE |
150:
GVPRFYIRIL | ADLEDYLNEL | WEDKEGKKKM | NKNNAKALST | LRQKIRKYNR |
200:
DFESHITNYK | QNPEQSADED | AEKNEEDSEG | SSDEDEDEDG | VGNTTFLKKK |
250:
QESSGESRKF | HKKMEDDDED | SEDSEDEEWD | TSSTSSDSDS | EEEEGKQTVL |
300:
ASKFLKKAPT | TEEDKKAAEK | KREDKAKKKH | DRKSKRLDEE | EEDNEGGEWE |
350:
RVRGGVPLVK | EKPKMFAKGT | EITHAVVIKK | LNEILQVRGK | KGTDRATQIE |
400:
LLQLLVQIAA | ENNLGVGVIV | KIKFNIIASL | YDYNPNLATY | MKPEMWQMCL |
450:
DCINELMDTL | VAHSNIFVGE | NILEESENLH | NFDQPLRVRG | CILTLVERMD |
500:
EEFTKIMQNT | DPHSQEYVEH | LKDEAQVCAI | IERVQRYLEE | KGTTEEICQI |
550:
YLRRILHTYY | KFDYKAHQRQ | LTPPEGSSKS | EQDQAENEGE | DSAVLMERLC |
600:
KYIYAKDRTD | RIRTCAILCH | IYHHALHSRW | YQARDLMLMS | HLQDNIQHAD |
650:
PPVQILYNRT | MVQLGICAFR | QGLTKDAHNA | LLDIQSSGRA | KELLGQGLLL |
700:
RSLQERNQEQ | EKVERRRQVP | FHLHINLELL | ECVYLVSAML | LEIPYMAAHE |
750:
SDARRRMISK | QFHHQLRVGE | RQPLLGPPES | MREHVVAASK | AMKMGDWKTC |
800:
HSFIINEKMN | GKVWDLFPEA | DKVRTMLVRK | IQEESLRTYL | FTYSSVYDSI |
850:
SMETLSDMFE | LDLPTVHSII | SKMIINEELM | ASLDQPTQTV | VMHRTEPTAQ |
900:
QNLALQLAEK | LGSLVENNER | VFDHKQGTYG | GYFRDQKDGY | RKNEGYMRRG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Bovine
Human
ELISA Kit for Mouse eIF3c
ELISA Kit for Mouse eIF3c
ELISA Kit for Mouse eIF3c
ELISA Kit for Mouse eIF3c
Polyclonal Antibody for Mouse eIF3c
Polyclonal Antibody for Mouse eIF3c
Polyclonal Antibody for Mouse eIF3c
Polyclonal Antibody for Mouse eIF3c
Monoclonal Antibody for Mouse eIF3c
Monoclonal Antibody for Mouse eIF3c
Monoclonal Antibody for Mouse eIF3c
Monoclonal Antibody for Mouse eIF3c
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Eye .
tissue :
Mammary tumor .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF THE EIF-3 COMPLEX;IDENTIFICATION IN THE EIF-3 COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Teratocarcinoma .
5.
"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
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Tweedie-Cullen R.
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Mansuy I.M.
Mol. Cell. Proteomics6:283-293(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain cortex .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
7.
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Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-99 AND LYS-641;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .