EIF3H ELISA Kit for Human(Homo sapiens) | EIAab.comEIF3H ELISA Kit for Human(Homo sapiens)

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EIF3H (Gene name),

Eukaryotic translation initiation factor 3 subunit H (Protein name ), EIF3H_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

EIF3H(EIF3S3);

Protein name:

Eukaryotic translation initiation factor 3 subunit H(eIF3h);

Alternative:

eIF-3-gamma;Eukaryotic translation initiation factor 3 subunit 3;eIF3 p40 subunit;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.

Function:

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

352

Sequence:

50:

100:

150:

200:

250:

300:

350:

352:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O15372

STRING:

9606.ENSP00000276682

MIM:

603912

Pfam:

PF01398

SMR:

O15372

KEGG:

hsa:8667

UniGene:

Hs.492599

Uniprot:

O15372

FOR

ELISA Kit for Human eIF3h

CLIA Kit for Human eIF3h

Polyclonal Antibody for Human eIF3h

Monoclonal Antibody for Human eIF3h

Protein for Human eIF3h

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly."
Asano K. , Vornlocher H.-P. , Richter-Cook N.J. , Merrick W.C. , Hinnebusch A.G. , Hershey J.W.B.
J. Biol. Chem.272:27042-27052(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

"The gene encoding the p40 subunit of the translation initiation factor eIF3 has 8 exons, maps to the Langer-Giedion syndrome region on chromosome 8q24, but is not the TRPS gene."
Schmidt O.G. , von Holtum D. , Gross S. , Horsthemke B. , Luedecke H.-J.
Submitted (1998-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
4.

"mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events."
Holz M.K. , Ballif B.A. , Gygi S.P. , Blenis J.
Cell123:569-580(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RPS6KB1;IDENTIFICATION BY MASS SPECTROMETRY
5.

"Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association."
Kolupaeva V.G. , Unbehaun A. , Lomakin I.B. , Hellen C.U.T. , Pestova T.V.
RNA11:470-486(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE EIF-3 COMPLEX
6.

"The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways."
Lee J.P. , Brauweiler A. , Rudolph M. , Hooper J.E. , Drabkin H.A. , Gemmill R.M.
Mol. Cancer Res.8:93-106(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF139
7.

"Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit."
LeFebvre A.K. , Korneeva N.L. , Trutschl M. , Cvek U. , Duzan R.D. , Bradley C.A. , Hershey J.W.B. , Rhoads R.E.
J. Biol. Chem.281:22917-22932(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE EIF-3 COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
8.

"Reconstitution reveals the functional core of mammalian eIF3."
Masutani M. , Sonenberg N. , Yokoyama S. , Imataka H.
EMBO J.26:3373-3383(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE EIF-3 COMPLEX
9.

"Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry."
Damoc E. , Fraser C.S. , Zhou M. , Videler H. , Mayeur G.L. , Hershey J.W.B. , Doudna J.A. , Robinson C.V. , Leary J.A.
Mol. Cell. Proteomics6:1135-1146(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE EIF-3 COMPLEX;CHARACTERIZATION OF THE EIF-3 COMPLEX;PHOSPHORYLATION AT SER-183;MASS SPECTROMETRY
10.

"Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3."
Zhou M. , Sandercock A.M. , Fraser C.S. , Ridlova G. , Stephens E. , Schenauer M.R. , Yokoi-Fong T. , Barsky D. , Leary J.A. , Hershey J.W.B. , Doudna J.A. , Robinson C.V.
Proc. Natl. Acad. Sci. U.S.A.105:18139-18144(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE EIF-3 COMPLEX;CHARACTERIZATION OF THE EIF-3 COMPLEX;MASS SPECTROMETRY;INTERACTION WITH EIF3B; EIF3F AND EIF3M
11.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Structural roles for human translation factor eIF3 in initiation of protein synthesis."
Siridechadilok B. , Fraser C.S. , Hall R.J. , Doudna J.A. , Nogales E.
Science310:1513-1515(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING;ELECTRON MICROSCOPY

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