Elf4 ELISA Kit for Mouse(Mus musculus) | EIAab.comElf4 ELISA Kit for Mouse(Mus musculus)

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Elf4 (Gene name),

ETS-related transcription factor Elf-4 (Protein name ), ELF4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Elf4(Mef);

Protein name:

ETS-related transcription factor Elf-4;

Alternative:

Myeloid Elf-1-like factor;E74-like factor 4;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.

Function:

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote celular transformation through inhibition of the p16 pathway.

Subcellular Location:

Nucleus PML body Accumulation into PML nuclear bodies is mediated by PML.

Protein Attributes:

Sequence length:

655

Sequence:

50:

100:

150:

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250:

300:

350:

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450:

500:

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600:

650:

655:

EPQDI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.36808

String:

Q9Z2U4

Pfam:

PF12310

KEGG:

mmu:56501

SMR:

Q9Z2U4

Uniprot:

Q9Z2U4

FOR

ELISA Kit for Mouse ETS-related transcription factor Elf-4

CLIA Kit for Mouse ETS-related transcription factor Elf-4

Polyclonal Antibody for Mouse ETS-related transcription factor Elf-4

Monoclonal Antibody for Mouse ETS-related transcription factor Elf-4

Protein for Mouse ETS-related transcription factor Elf-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Murine MEF (myeloid elf-1-like factor) cDNA clone."
Miyazaki Y. , De Blasio T. , Nimer S.D.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells."
Lacorazza H.D. , Miyazaki Y. , Di Cristofano A. , Deblasio A. , Hedvat C. , Zhang J. , Cordon-Cardo C. , Mao S. , Pandolfi P.P. , Nimer S.D.
Immunity17:437-449(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation."
Sashida G. , Liu Y. , Elf S. , Miyata Y. , Ohyashiki K. , Izumi M. , Menendez S. , Nimer S.D.
Mol. Cell. Biol.29:3687-3699(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2."
Yamada T. , Park C.S. , Mamonkin M. , Lacorazza H.D.
Nat. Immunol.10:618-626(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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