In bone physiology, the C-terminal telopeptide (or more formally, carboxy-terminal collagen crosslinks, and known by the acronym CTX) is a serum biomarker used to measure the rate of bone turnover. It can be useful in assisting clinicians to determine a patient's nonsurgical treatment response as well as evaluate a patient's risk of developing complications during healing following surgical intervention. The test used to detect the CTX marker is called the Serum CrossLaps, and it is more specific to bone resorption than any other test currently available.
Protein for Rat C-telopeptide of Collagen alpha-1(II) chain
R&D Technical Data
12% SDS-PAGE analysis
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Precision
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤4.3%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤7.5%
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Recovery
Recovery was determined by spiking various levels of CTXII into serum and plasma .
Sample Type
Average(%)
Recovery Range (%)
Serum
97
93-102
Plasma
96
89-104
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Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of CTXII and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1：2
1:4
1:8
1:16
serum(n=5)
85-98%
89-101%
92-106%
90-101%
EDTA plasma(n=5)
84-99%
80-97%
79-98%
83-100%
heparin plasma(n=5)
87-104%
89-103%
86-98%
79-95%
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Vaild Sequence:
