ACTN1 ELISA Kit for Human(Homo sapiens) | EIAab.comACTN1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ACTN1(Gene name) > Human

ACTN1 (Gene name),

Alpha-actinin-1 (Protein name ), ACTN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ACTN1;

Protein name:

Alpha-actinin-1;

Alternative:

F-actin cross-linking protein;Alpha-actinin cytoskeletal isoform;Non-muscle alpha-actinin-1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP. Interacts with PSD.

Function:

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

Subcellular Location:

Cytoplasm cytoskeleton Cytoplasm myofibril sarcomere Z line Cell membrane Cell projection ruffle Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures.

Protein Attributes:

Sequence length:

892

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

892:

ELPPDQAEYC | IARMAPYTGP | DSVPGALDYM | SFSTALYGES | DL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P12814

MIM:

102575

Pfam:

PF00307

UniGene:

Hs.509765

String:

P12814

KEGG:

hsa:87

STRING:

9606.ENSP00000377941

Uniprot:

P12814

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ELISA Kit for Human Alpha-actinin-1

Cat.:

E0376h

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96T

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ELISA Kit for Human Alpha-actinin-1

Cat.:

E0376c

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96T

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ELISA Kit for Human Alpha-actinin-1

Cat.:

E0376r

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96T

ELISA Kit for Human Alpha-actinin-1

Cat.:

E0376b

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96T

ELISA Kit for Human Alpha-actinin-1

Cat.:

E0376m

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96T

CLIA Kit for Human Alpha-actinin-1

Cat.:

U0376c

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96T

CLIA Kit for Human Alpha-actinin-1

Cat.:

U0376h

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96T

CLIA Kit for Human Alpha-actinin-1

Cat.:

U0376m

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96T

CLIA Kit for Human Alpha-actinin-1

Cat.:

U0376r

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96T

CLIA Kit for Human Alpha-actinin-1

Cat.:

U0376b

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96T

Polyclonal Antibody for Human Alpha-actinin-1

Cat.:

P0376Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Alpha-actinin-1

Cat.:

P0376Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Alpha-actinin-1

Cat.:

P0376Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Alpha-actinin-1

Protein for Human Alpha-actinin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The cDNA sequence of a human placental alpha-actinin."
Millake D.B. , Blanchard A.D. , Patel B. , Critchley D.R.
Nucleic Acids Res.17:6725-6725(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Placenta.
2.

"Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene."
Youssoufian H. , McAfee M. , Kwiatkowski D.J.
Am. J. Hum. Genet.47:62-71(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis."
Thorsen K. , Sorensen K.D. , Brems-Eskildsen A.S. , Modin C. , Gaustadnes M. , Hein A.M. , Kruhoffer M. , Laurberg S. , Borre M. , Wang K. , Brunak S. , Krainer A.R. , Torring N. , Dyrskjot L. , Andersen C.L. , Orntoft T.F.
Mol. Cell. Proteomics7:1214-1224(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
4.

"A new mRNA isoform from ACTN1 gene."
Mancini U.M. , Tajara E.H.
Submitted (2006-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Tongue.
5.

"Actinin alpha 1 alternative splicing variant."
Mansilla F. , Orntoft T.F. , Birkenkamp-Demtroeder K.
Submitted (2008-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
8.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
tissue: Skin.
11.

"Expression of human alpha-actinin in human hepatocellular carcinoma."
Nishiyama M. , Ozturk M. , Frohlich M. , Mafune K. , Steele G. Jr. , Wands J.R.
Cancer Res.50:6291-6294(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 297-892 (ISOFORM 1)
12.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-21
tissue: Platelet.
13.

"Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes."
Egerton M. , Moritz R.L. , Druker B. , Kelso A. , Simpson R.J.
Biochem. Biophys. Res. Commun.224:666-674(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 134-146
14.

"Identification of the cytoskeletal protein alpha-actinin as a platelet thrombospondin-binding protein."
Dubernard V. , Faucher D. , Launay J.-M. , Legrand C.
FEBS Lett.364:109-114(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 566-577; 727-738 AND 835-863;SUBCELLULAR LOCATION
15.

"Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy."
Salmikangas P. , Mykkaenen O.M. , Groenholm M. , Heiska L. , Kere J. , Carpen O.
Hum. Mol. Genet.8:1329-1336(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TTID
16.

"Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."
Frey N. , Richardson J.A. , Olson E.N.
Proc. Natl. Acad. Sci. U.S.A.97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYOZ2
17.

"The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase."
Izaguirre G. , Aguirre L. , Hu Y.P. , Lee H.Y. , Schlaepfer D.D. , Aneskievich B.J. , Haimovich B.
J. Biol. Chem.276:28676-28685(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-12
18.

"The lipoma preferred partner LPP interacts with alpha-actinin."
Li B. , Zhuang L. , Reinhard M. , Trueb B.
J. Cell Sci.116:1359-1366(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LPP
19.

"Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring."
Kremerskothen J. , Kindler S. , Finger I. , Veltel S. , Barnekow A.
J. Neurochem.96:1659-1666(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDN
20.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-95; LYS-195 AND LYS-676;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models."
Borrego-Diaz E. , Kerff F. , Lee S.H. , Ferron F. , Li Y. , Dominguez R.
J. Struct. Biol.155:230-238(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 30-253
24.

"ACTN1 mutations cause congenital macrothrombocytopenia."
Kunishima S. , Okuno Y. , Yoshida K. , Shiraishi Y. , Sanada M. , Muramatsu H. , Chiba K. , Tanaka H. , Miyazaki K. , Sakai M. , Ohtake M. , Kobayashi R. , Iguchi A. , Niimi G. , Otsu M. , Takahashi Y. , Miyano S. , Saito H. , more...
Am. J. Hum. Genet.92:431-438(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BDPLT15 LYS-32; GLN-46; ILE-105; LYS-225; TRP-738 AND GLN-752;VARIANT TRP-197;CHARACTERIZATION OF VARIANTS BDPLT15 LYS-32 AND ILE-105

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