Aimp1 ELISA Kit for Mouse(Mus musculus) | EIAab.comAimp1 ELISA Kit for Mouse(Mus musculus)

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Aimp1 (Gene name),

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Protein name ), AIMP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Aimp1(Emap2;Scye1);

Protein name:

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;

Alternative:

Multisynthase complex auxiliary component p43;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer (By similarity). Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts (via N-terminus) with RARS (via N-terminus). Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with HSP90B1/gp96 (via C-terminus). Interacts with PSMA7.

Function:

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Subcellular Location:

Nucleus Cytoplasm cytosol Cytoplasmic vesicle secretory vesicle Secreted Endoplasmic reticulum Golgi apparatus Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels. Also secreted in response to hypoxia and both apoptotic and necrotic cell death.

Protein Attributes:

Sequence length:

310

Sequence:

50:

100:

150:

200:

250:

300:

310:

AQTMANSGIK |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.235137

SMR:

P31230

Pfam:

PF01588

String:

P31230

Uniprot:

P31230

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ELISA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

E2214h

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96T

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ELISA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

E2214m

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

U2214m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

U2214h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

P2214Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Cat.:

P2214Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Protein for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II."
Kao J. , Houck K. , Fan Y. , Haehnel I. , Libutti S.K. , Kayton M.L. , Grikscheit T. , Chabot J. , Nowygrod R. , Greenberg S. , Kuang W.J. , Leung D.W. , Hayward J.R. , Kisiel W. , Heath M. , Brett J. , Stern D.M.
J. Biol. Chem.269:25106-25119(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.

"Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms."
Kao J. , Ryan J. , Brett G. , Chen J. , Shen H. , Fan Y.-G. , Godman G. , Familletti P.C. , Wang F. , Pan Y.-C.E. , Stern D. , Clauss M.
J. Biol. Chem.267:20239-20247(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 145-164;FUNCTION
4.

"A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response."
Kao J. , Fan Y. , Haehnel I. , Brett J. , Greenberg S. , Clauss M. , Kayton M. , Houck K. , Kisiel W. , Seljelid R. , Burnier J. , Stern D.
J. Biol. Chem.269:9774-9782(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Regulation of endothelial monocyte-activating polypeptide II release by apoptosis."
Knies U.E. , Behrensdorf H.A. , Mitchell C.A. , Deutsch U. , Risau W. , Drexler H.C.A. , Clauss M.
Proc. Natl. Acad. Sci. U.S.A.95:12322-12327(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.

"The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component."
Shalak V. , Kaminska M. , Mitnacht-Kraus R. , Vandenabeele P. , Clauss M. , Mirande M.
J. Biol. Chem.276:23769-23776(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE
7.

"The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair."
Park S.G. , Shin H. , Shin Y.K. , Lee Y. , Choi E.-C. , Park B.-J. , Kim S.
Am. J. Pathol.166:387-398(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Hormonal activity of AIMP1/p43 for glucose homeostasis."
Park S.G. , Kang Y.S. , Kim J.Y. , Lee C.S. , Ko Y.G. , Lee W.J. , Lee K.-U. , Yeom Y.I. , Kim S.
Proc. Natl. Acad. Sci. U.S.A.103:14913-14918(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.

"Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases."
Han J.M. , Park S.G. , Liu B. , Park B.-J. , Kim J.Y. , Jin C.H. , Song Y.W. , Li Z. , Kim S.
Am. J. Pathol.170:2042-2054(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HSP90B1;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE
10.

"AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2."
Lee Y.S. , Han J.M. , Son S.H. , Choi J.W. , Jeon E.J. , Bae S.-C. , Park Y.I. , Kim S.
Biochem. Biophys. Res. Commun.371:395-400(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMURF2;INDUCTION
11.

"AIMP1/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability."
Kim E. , Kim S.H. , Kim S. , Cho D. , Kim T.S.
J. Immunol.180:2894-2902(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-267;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.

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