Aimp2 ELISA Kit for Mouse(Mus musculus) | EIAab.comAimp2 ELISA Kit for Mouse(Mus musculus)

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Aimp2 (Gene name),

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Protein name ), AIMP2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Aimp2(Jtv1);

Protein name:

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2;

Alternative:

Protein JTV-1;Multisynthase complex auxiliary component p38;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain).

Function:

Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Subcellular Location:

Cytoplasm cytosol Nucleus Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.

Protein Attributes:

Sequence length:

320

Sequence:

50:

100:

150:

200:

250:

300:

320:

RWLKSCENLA | PFSTALQLLK |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.200499

KEGG:

mmu:231872

String:

Q8R010

SMR:

Q8R010

STRING:

10090.ENSMUSP00000031613

Uniprot:

Q8R010

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ELISA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

E2927h

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Manual:

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96T

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ELISA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

E2927r

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Packing:

96T

ELISA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

E2927m

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96T

ELISA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

E2927b

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Packing:

96T

CLIA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

U2927b

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

U2927m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

U2927r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

U2927h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

P2927Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

P2927Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Cat.:

P2927Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Protein for Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Czech II.
strain: FVB/N.
strain: FVB/N-3.
tissue: Mammary tumor.
3.

"p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance."
Kim J.Y. , Kang Y.-S. , Lee J.-W. , Kim H.J. , Ahn Y.H. , Park H. , Ko Y.-G. , Kim S.
Proc. Natl. Acad. Sci. U.S.A.99:7912-7916(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
4.

"Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation."
Kim M.J. , Park B.-J. , Kang Y.-S. , Kim H.J. , Park J.-H. , Kang J.W. , Lee S.W. , Han J.M. , Lee H.-W. , Kim S.
Nat. Genet.34:330-336(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
5.

"Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death."
Ko H.S. , von Coelln R. , Sriram S.R. , Kim S.W. , Chung K.K.K. , Pletnikova O. , Troncoso J. , Johnson B. , Saffary R. , Goh E.L. , Song H. , Park B.-J. , Kim M.J. , Kim S. , Dawson V.L. , Dawson T.M.
J. Neurosci.25:7968-7978(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
7.

"AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53."
Han J.M. , Park B.-J. , Park S.G. , Oh Y.S. , Choi S.J. , Lee S.W. , Hwang S.-K. , Chang S.-H. , Cho M.-H. , Kim S.
Proc. Natl. Acad. Sci. U.S.A.105:11206-11211(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION

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