Akr7a3 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAkr7a3 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Akr7a3(Gene name) > Rat

Akr7a3 (Gene name),

Aflatoxin B1 aldehyde reductase member 3 (Protein name ), ARK73_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Akr7a3(Afar;Akr7a1);

Protein name:

Aflatoxin B1 aldehyde reductase member 3(AFB1-AR);

Alternative:

Aflatoxin B1 aldehyde reductase member 1(rAFAR1);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer. Heterodimer with AKR7A2.

Function:

Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Probably involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

327

Sequence:

50:

100:

150:

200:

250:

300:

327:

GPLEPAVVDA | FDQAWNLVAH | ECPNYFR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.6043

SMR:

P38918

String:

P38918

Pfam:

PF00248

KEGG:

rno:26760

Uniprot:

P38918

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ELISA Kit for Rat AFB1-AR

Cat.:

E3483h

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Packing:

96T

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ELISA Kit for Rat AFB1-AR

Cat.:

E3483r

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96T

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CLIA Kit for Rat AFB1-AR

Cat.:

U3483r

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MSDS:

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Packing:

96T

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CLIA Kit for Rat AFB1-AR

Cat.:

U3483h

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Manual:

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Packing:

96T

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Polyclonal Antibody for Rat AFB1-AR

Cat.:

P3483Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat AFB1-AR

Cat.:

P3483Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat AFB1-AR

Protein for Rat AFB1-AR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases."
Ellis E.M. , Judah D.J. , Neal G.E. , Hayes J.D.
Proc. Natl. Acad. Sci. U.S.A.90:10350-10354(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Fischer 344.
tissue: Liver.
2.

"cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3."
Knight L.P. , Primiano T. , Groopman J.D. , Kensler T.W. , Sutter T.R.
Carcinogenesis20:1215-1223(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION
strain: Fischer 344.
tissue: Liver.
3.

"Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter."
Ellis E.M. , Slattery C.M. , Hayes J.D.
Carcinogenesis24:727-737(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: Fischer 344.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
5.

Raymackers J. , Anderson L.
Submitted (1994-11) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 6-17; 89-97; 156-184; 232-246 AND 250-274
tissue: Liver.
6.

"Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin."
Hayes J.D. , Judah D.J. , Neal G.E.
Cancer Res.53:3887-3894(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
7.

"Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins."
Kelly V.P. , Sherratt P.J. , Crouch D.H. , Hayes J.D.
Biochem. J.366:847-861(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COFACTOR;SUBUNIT
8.

"The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily."
Kozma E. , Brown E. , Ellis E.M. , Lapthorn A.J.
J. Biol. Chem.277:16285-16293(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) IN COMPLEX WITH NADP AND CITRATE;SUBUNIT

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