CD79A ELISA Kit for Human(Homo sapiens) | EIAab.comCD79A ELISA Kit for Human(Homo sapiens)

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CD79A (Gene name),

B-cell antigen receptor complex-associated protein alpha chain (Protein name ), CD79A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CD79A(IGA;MB1);

Protein name:

B-cell antigen receptor complex-associated protein alpha chain;

Alternative:

MB-1 membrane glycoprotein;Ig-alpha;Surface IgM-associated protein;Membrane-bound immunoglobulin-associated protein;

CD:

CD79a;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-210, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity.

Function:

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

Protein Attributes:

Sequence length:

226

Sequence:

50:

100:

150:

200:

226:

DISRGLQGTY | QDVGSLNIGD | VQLEKP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:973

STRING:

9606.ENSP00000221972

SMR:

P11912

String:

P11912

UniGene:

Hs.631567

Pfam:

PF02189

MIM:

112205

Uniprot:

P11912

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ELISA Kit for Human B-cell antigen receptor complex-associated protein alpha chain

Cat.:

E15278d

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96T

ELISA Kit for Human B-cell antigen receptor complex-associated protein alpha chain

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E15278b

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96T

ELISA Kit for Human B-cell antigen receptor complex-associated protein alpha chain

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E15278m

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96T

ELISA Kit for Human B-cell antigen receptor complex-associated protein alpha chain

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E15278h

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96T

CLIA Kit for Human B-cell antigen receptor complex-associated protein alpha chain

Cat.:

U15278b

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Packing:

96T

CLIA Kit for Human B-cell antigen receptor complex-associated protein alpha chain

Cat.:

U15278m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human B-cell antigen receptor complex-associated protein alpha chain

Cat.:

U15278h

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MSDS:

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Packing:

96T

CLIA Kit for Human B-cell antigen receptor complex-associated protein alpha chain

Cat.:

U15278d

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human B-cell antigen receptor complex-associated protein alpha chain

Cat.:

P15278Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human B-cell antigen receptor complex-associated protein alpha chain

Cat.:

P15278Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human B-cell antigen receptor complex-associated protein alpha chain

Monoclonal Antibody for Human B-cell antigen receptor complex-associated protein alpha chain

Protein for Human B-cell antigen receptor complex-associated protein alpha chain

R&D Technical Data

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Precision

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Recovery

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References

1.

"Structure and expression of the mb-1 transcript in human lymphoid cells."
Leduc I. , Preud'Homme J.L. , Cogne M.
Clin. Exp. Immunol.90:141-146(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29."
Mueller B.S. , Cooper L. , Terhorst C.
Eur. J. Immunol.22:1621-1625(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Tonsil.
3.

"Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex."
Flaswinkel H. , Reth M.
Immunogenetics36:266-269(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes."
Yu L.M. , Chang T.W.
J. Immunol.148:633-637(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

"Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene."
Ha H.J. , Kubagawa H. , Burrows P.D.
J. Immunol.148:1526-1531(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
6.

"Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene."
Hashimoto S. , Mohrenweiser H.W. , Gregersen P.K. , Chiorazzi N.
Immunogenetics40:287-295(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
7.

"Structure, chromosomal localization, and methylation pattern of the human mb-1 gene."
Ha H. , Barnoski B.L. , Sun L. , Emanuel B.S. , Burrows P.D.
J. Immunol.152:5749-5757(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells."
Hashimoto S. , Chiorazzi N. , Gregersen P.K.
Mol. Immunol.32:651-659(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
9.

Koyama M. , Nakamura T.
Submitted (1994-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
10.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Small intestine.
11.

"Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex."
Vasile S. , Coligan J.E. , Yoshida M. , Seon B.K.
Mol. Immunol.31:419-427(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-52
12.

"B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties."
Sakaguchi N. , Kashiwamura S. , Kimoto M. , Thalmann P. , Melchers F.
EMBO J.7:3457-3464(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 190-226 (ISOFORM 1)
13.

"Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex."
Luisiri P. , Lee Y.J. , Eisfelder B.J. , Clark M.R.
J. Biol. Chem.271:5158-5163(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta."
Tseng J. , Eisfelder B.J. , Clark M.R.
Blood89:1513-1520(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"Mutations in Igalpha (CD79a) result in a complete block in B-cell development."
Minegishi Y. , Coustan-Smith E. , Rapalus L. , Ersoy F. , Campana D. , Conley M.E.
J. Clin. Invest.104:1115-1121(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AGM3
16.

"The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction."
Mueller R. , Wienands J. , Reth M.
Proc. Natl. Acad. Sci. U.S.A.97:8451-8454(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;MUTAGENESIS OF SER-197; SER-203 AND THR-209
17.

"Novel Igalpha (CD79a) gene mutation in a Turkish patient with B cell-deficient agammaglobulinemia."
Wang Y. , Kanegane H. , Sanal O. , Tezcan I. , Ersoy F. , Futatani T. , Miyawaki T.
Am. J. Med. Genet.108:333-336(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AGM3
18.

"Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor."
Gaul B.S. , Harrison M.L. , Geahlen R.L. , Burton R.A. , Post C.B.
J. Biol. Chem.275:16174-16182(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 184-195;PHOSPHORYLATION;INTERACTION WITH LYN

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