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Index > Protein center > CHAT(Gene name) > Human
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  • CHAT (Gene name),
  • Choline O-acetyltransferase (Protein name ),  CLAT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CHAT;
    Protein name:
    Choline O-acetyltransferase(CHOACTase;ChAT;Choline acetylase);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    748
    Sequence:
    50:
    MGLRTAKKRG | LGGGGKWKRE | EGGGTRGRRE | VRPACFLQSG | GRGDPGDVGG | 
    100:
    PAGNPGCSPH | PRAATRPPPL | PAHTPAHTPE | WCGAASAEAA | EPRRAGPHLC | 
    150:
    IPAPGLTKTP | ILEKVPRKMA | AKTPSSEESG | LPKLPVPPLQ | QTLATYLQCM | 
    200:
    RHLVSEEQFR | KSQAIVQQFG | APGGLGETLQ | QKLLERQEKT | ANWVSEYWLN | 
    250:
    DMYLNNRLAL | PVNSSPAVIF | ARQHFPGTDD | QLRFAASLIS | GVLSYKALLD | 
    300:
    SHSIPTDCAK | GQLSGQPLCM | KQYYGLFSSY | RLPGHTQDTL | VAQNSSIMPE | 
    350:
    PEHVIVACCN | QFFVLDVVIN | FRRLSEGDLF | TQLRKIVKMA | SNEDERLPPI | 
    400:
    GLLTSDGRSE | WAEARTVLVK | DSTNRDSLDM | IERCICLVCL | DAPGGVELSD | 
    450:
    THRALQLLHG | GGYSKNGANR | WYDKSLQFVV | GRDGTCGVVC | EHSPFDGIVL | 
    500:
    VQCTEHLLKH | VTQSSRKLIR | ADSVSELPAP | RRLRWKCSPE | IQGHLASSAE | 
    550:
    KLQRIVKNLD | FIVYKFDNYG | KTFIKKQKCS | PDAFIQVALQ | LAFYRLHRRL | 
    600:
    VPTYESASIR | RFQEGRVDNI | RSATPEALAF | VRAVTDHKAA | VPASEKLLLL | 
    650:
    KDAIRAQTAY | TVMAITGMAI | DNHLLALREL | ARAMCKELPE | MFMDETYLMS | 
    700:
    NRFVLSTSQV | PTTTEMFCCY | GPVVPNGYGA | CYNPQPETIL | FCISSFHSCK | 
    748:
    ETSSSKFAKA | VEESLIDMRD | LCSLLPPTES | KPLATKEKAT | RPSQGHQP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    KEGG:
    MIM:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human CHOACTase
    Cat.:
    E1428r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human CHOACTase
    Cat.:
    E1428m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human CHOACTase
    Cat.:
    E1428h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human CHOACTase
    Cat.:
    E1428c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human CHOACTase
    Cat.:
    E1428p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CHOACTase
    Cat.:
    U1428p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CHOACTase
    Cat.:
    U1428c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CHOACTase
    Cat.:
    U1428h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CHOACTase
    Cat.:
    U1428m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human CHOACTase
    Cat.:
    U1428r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human CHOACTase
    Polyclonal Antibody for Human CHOACTase
    Cat.:
    P1428Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CHOACTase
    Cat.:
    P1428Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CHOACTase
    Cat.:
    P1428Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CHOACTase
    Monoclonal Antibody for Human CHOACTase
    Monoclonal Antibody for Human CHOACTase
    Monoclonal Antibody for Human CHOACTase
    Monoclonal Antibody for Human CHOACTase
    Monoclonal Antibody for Human CHOACTase
    Protein for Human CHOACTase
    Protein for Human CHOACTase
    Protein for Human CHOACTase
    Protein for Human CHOACTase
    Protein for Human CHOACTase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A complementary DNA for human choline acetyltransferase induces two forms of enzyme with different molecular weights in cultured cells."
      Oda Y. , Nakanishi I. , Deguchi T.
      Brain Res. Mol. Brain Res.16:287-294(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM M);VARIANTS GLY-392 AND MET-461
      tissue: Spinal cord.
    2. 2.
      "Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans."
      Ohno K. , Tsujino A. , Brengman J.M. , Harper C.M. , Bajzer Z. , Udd B. , Beyring R. , Robb S. , Kirkham F.J. , Engel A.G.
      Proc. Natl. Acad. Sci. U.S.A.98:2017-2022(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS M; R AND S);ALTERNATIVE SPLICING;VARIANTS CMSEA PRO-210; ALA-211; THR-305; CYS-420; LYS-441; GLY-482; LEU-498; LEU-506 AND HIS-560;VARIANTS THR-120; GLY-392 AND MET-461
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM R);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-748 (ISOFORM M);VARIANTS THR-120 AND MET-461
    6. 6.
      "Two mRNAs are transcribed from the human gene for choline acetyltransferase."
      Lorenzi M.V. , Trinidad A.C. , Zhang R. , Strauss W.L.
      DNA Cell Biol.11:593-603(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 111-669;VARIANTS THR-120 AND MET-461
    7. 7.
      "Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions."
      Toussaint J.L. , Geoffroy V. , Schmitt M. , Werner A. , Garnier J.-M. , Simoni P. , Kempf J.
      Genomics12:412-416(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 109-232
    8. 8.
      "Conservation of amino acid sequences between human and porcine choline acetyltransferase."
      Hersh L.B. , Takane K. , Gylys K. , Moomaw C. , Slaughter C.
      J. Neurochem.51:1843-1845(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 161-182; 271-295; 340-352; 376-382; 404-415; 550-559; 572-583; 620-632; 644-648; 650-662 AND 739-748
      tissue: Placenta.
    9. 9.
      "Isolation and sub-chromosomal localization of a DNA fragment of the human choline acetyltransferase gene."
      Cervini R. , Rocchi M. , DiDonato S. , Finocchiaro G.
      Neurosci. Lett.132:191-194(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 688-738
      tissue: Lymphocyte.
    10. 10.
      "Substrate binding and catalytic mechanism of human choline acetyltransferase."
      Kim A.-R. , Rylett R.J. , Shilton B.H.
      Biochemistry45:14621-14631(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 120-733 IN COMPLEXES WITH CHOLINE AND ACETYL COENZYME A
    11. 11.
      "Congenital myasthenic syndrome with episodic apnea in patients homozygous for a CHAT missense mutation."
      Kraner S. , Laufenberg I. , Strassburg H.M. , Sieb J.P. , Steinlein O.K.
      Arch. Neurol.60:761-763(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMSEA THR-336
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