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Index > Protein center > Drd2(Gene name) > Mouse
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  • Drd2 (Gene name),
  • D(2) dopamine receptor (Protein name ),  DRD2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Drd2;
    Protein name:
    D(2) dopamine receptor;
    Alternative:
    Dopamine D2 receptor;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B, CADPS, CADPS2 and CLIC6. Interacts with ARRB2 and GNAI1.
    Function:
    Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    444
    Sequence:
    50:
    MDPLNLSWYD | DDLERQNWSR | PFNGSEGKPD | RPHYNYYAML | LTLLIFIIVF | 
    100:
    GNVLVCMAVS | REKALQTTTN | YLIVSLAVAD | LLVATLVMPW | VVYLEVVGEW | 
    150:
    KFSRIHCDIF | VTLDVMMCTA | SILNLCAISI | DRYTAVAMPM | LYNTRYSSKR | 
    200:
    RVTVMIAIVW | VLSFTISCPL | LFGLNNTDQN | ECIIANPAFV | VYSSIVSFYV | 
    250:
    PFIVTLLVYI | KIYIVLRKRR | KRVNTKRSSR | AFRANLKTPL | KGNCTHPEDM | 
    300:
    KLCTVIMKSN | GSFPVNRRRM | DAARRAQELE | MEMLSSTSPP | ERTRYSPIPP | 
    350:
    SHHQLTLPDP | SHHGLHSNPD | SPAKPEKNGH | AKIVNPRIAK | FFEIQTMPNG | 
    400:
    KTRTSLKTMS | RRKLSQQKEK | KATQMLAIVL | GVFIICWLPF | FITHILNIHC | 
    444:
    DCNIPPVLYS | AFTWLGYVNS | AVNPIIYTTF | NIEFRKAFMK | ILHC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse D(2) dopamine receptor
    Cat.:
    E0673m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse D(2) dopamine receptor
    Cat.:
    E0673r
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse D(2) dopamine receptor
    Cat.:
    E0673h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse D(2) dopamine receptor
    Cat.:
    E0673b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse D(2) dopamine receptor
    Cat.:
    E0673d
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse D(2) dopamine receptor
    Cat.:
    U0673m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse D(2) dopamine receptor
    Cat.:
    U0673h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse D(2) dopamine receptor
    Cat.:
    U0673r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse D(2) dopamine receptor
    Cat.:
    U0673b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse D(2) dopamine receptor
    Cat.:
    U0673d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse D(2) dopamine receptor
    Polyclonal Antibody for Mouse D(2) dopamine receptor
    Cat.:
    P0673Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse D(2) dopamine receptor
    Polyclonal Antibody for Mouse D(2) dopamine receptor
    Cat.:
    P0673Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse D(2) dopamine receptor
    Cat.:
    P0673Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse D(2) dopamine receptor
    Monoclonal Antibody for Mouse D(2) dopamine receptor
    Monoclonal Antibody for Mouse D(2) dopamine receptor
    Monoclonal Antibody for Mouse D(2) dopamine receptor
    Monoclonal Antibody for Mouse D(2) dopamine receptor
    Protein for Mouse D(2) dopamine receptor
    Protein for Mouse D(2) dopamine receptor
    Protein for Mouse D(2) dopamine receptor
    Protein for Mouse D(2) dopamine receptor
    Protein for Mouse D(2) dopamine receptor

    R&D Technical Data
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    s

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    s
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤7.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤10.8%

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

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    Recovery
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    Recovery was determined by spiking various levels of DRD2 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    101

    94-107

    Plasma

    100

    92-106

     

     

     

     

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    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of DRD2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    94-108%

    96-107%

    93-110%

    97-104%

    EDTA plasma(n=5)

    92-108%

    91-110%

    92-106%

    94-108%

    heparin plasma(n=5)

    95-106%

     

    93-107%

    95-105%

    91-109%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Differential expression of the mouse D2 dopamine receptor isoforms."
      Montmayeur J.P. , Bausero P. , Amlaiky N. , Maroteaux L. , Hen R. , Borrelli E.
      FEBS Lett.278:239-243(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    2. 2.
      "A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus."
      Chio C.L. , Hess G.F. , Graham R.S. , Huff R.M.
      Nature343:266-269(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "The dopamine D2 receptor: two molecular forms generated by alternative splicing."
      Dal-Toso R. , Sommer B. , Ewert M. , Herb A. , Pritchett D.B. , Bach A. , Shivers B.D. , Seeburg P.H.
      EMBO J.8:4025-4034(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 175-270 (ISOFORM 1)
    6. 6.
      "Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow."
      Fulton S. , Thibault D. , Mendez J.A. , Lahaie N. , Tirotta E. , Borrelli E. , Bouvier M. , Tempel B.L. , Trudeau L.E.
      J. Biol. Chem.286:9360-9372(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCNA2
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