EFEMP1 ELISA Kit for Human(Homo sapiens) | EIAab.comEFEMP1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > EFEMP1(Gene name) > Human

EFEMP1 (Gene name),

EGF-containing fibulin-like extracellular matrix protein 1 (Protein name ), FBLN3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

EFEMP1(FBLN3;FBNL);

Protein name:

EGF-containing fibulin-like extracellular matrix protein 1;

Alternative:

Fibrillin-like protein;Extracellular protein S1-5;Fibulin-3(FIBL-3);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ECM1. Interacts with TIMP3.

Function:

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.

Subcellular Location:

Secreted extracellular space Secreted extracellular space extracellular matrix Localizes to the lamina propria underneath the olfactory epithelium.

Protein Attributes:

Sequence length:

493

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

493:

LVKSLSGPRE | HIVDLEMLTV | SSIGTFRTSS | VLRLTIIVGP | FSF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.732348

SMR:

Q12805

Pfam:

PF07645

UniGene:

Hs.76224

Pfam:

PF12662

String:

Q12805

MIM:

126600

KEGG:

hsa:2202

STRING:

9606.ENSP00000347596

Uniprot:

Q12805

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ELISA Kit for Human EGF-containing fibulin-like extracellular matrix protein 1

Cat.:

E11818h

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Manual:

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Packing:

96T

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ELISA Kit for Human EGF-containing fibulin-like extracellular matrix protein 1

Cat.:

E11818m

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MSDS:

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Packing:

96T

ELISA Kit for Human EGF-containing fibulin-like extracellular matrix protein 1

Cat.:

E11818r

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Packing:

96T

CLIA Kit for Human EGF-containing fibulin-like extracellular matrix protein 1

Cat.:

U11818r

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Packing:

96T

CLIA Kit for Human EGF-containing fibulin-like extracellular matrix protein 1

Cat.:

U11818h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human EGF-containing fibulin-like extracellular matrix protein 1

Cat.:

U11818m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human EGF-containing fibulin-like extracellular matrix protein 1

Cat.:

P11818Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human EGF-containing fibulin-like extracellular matrix protein 1

Cat.:

P11818Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human EGF-containing fibulin-like extracellular matrix protein 1

Cat.:

P11818Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human EGF-containing fibulin-like extracellular matrix protein 1

Protein for Human EGF-containing fibulin-like extracellular matrix protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"An overexpressed gene transcript in senescent and quiescent human fibroblasts encoding a novel protein in the epidermal growth factor-like repeat family stimulates DNA synthesis."
Lecka-Czernik B. , Lumpkin C.K. Jr. , Goldstein S.
Mol. Cell. Biol.15:120-128(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];POSSIBLE ALTERNATIVE SPLICING
tissue: Skin.
2.

"Structure and chromosomal assignment of the human S1-5 gene (FBNL) that is highly homologous to fibrillin."
Ikegawa S. , Toda T. , Okui K. , Nakamura Y.
Genomics35:590-592(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4."
Giltay R. , Timpl R. , Kostka G.
Matrix Biol.18:469-480(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"EFEMP1 is not associated with sporadic early onset drusen."
Sauer C.G. , White K. , Kellner U. , Rudolph G. , Jurklies B. , Pauleikhoff D. , Weber B.H.
Ophthalmic Genet.22:27-34(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
tissue: Synovium.
6.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
9.

"Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration."
Marmorstein L.Y. , Munier F.L. , Arsenijevic Y. , Schorderet D.F. , McLaughlin P.J. , Chung D. , Traboulsi E. , Marmorstein A.D.
Proc. Natl. Acad. Sci. U.S.A.99:13067-13072(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;CHARACTERIZATION OF VARIANT DHRD TRP-345
10.

"Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations."
Klenotic P.A. , Munier F.L. , Marmorstein L.Y. , Anand-Apte B.
J. Biol. Chem.279:30469-30473(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIMP3
11.

"EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells."
Camaj P. , Seeliger H. , Ischenko I. , Krebs S. , Blum H. , De Toni E.N. , Faktorova D. , Jauch K.W. , Bruns C.J.
Biol. Chem.390:1293-1302(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN EGFR ACTIVATION
12.

"ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain."
Sercu S. , Lambeir A.M. , Steenackers E. , El Ghalbzouri A. , Geentjens K. , Sasaki T. , Oyama N. , Merregaert J.
Matrix Biol.28:160-169(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ECM1
13.

"Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion."
Hu B. , Thirtamara-Rajamani K.K. , Sim H. , Viapiano M.S.
Mol. Cancer Res.7:1756-1770(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Fibulin-3 negatively regulates chondrocyte differentiation."
Wakabayashi T. , Matsumine A. , Nakazora S. , Hasegawa M. , Iino T. , Ota H. , Sonoda H. , Sudo A. , Uchida A.
Biochem. Biophys. Res. Commun.391:1116-1121(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
15.

"A single EFEMP1 mutation associated with both malattia Leventinese and Doyne honeycomb retinal dystrophy."
Stone E.M. , Lotery A.J. , Munier F.L. , Heon E. , Piguet B. , Guymer R.H. , Vandenburgh K. , Cousin P. , Nishimura D. , Swiderski R.E. , Silvestri G. , Mackey D.A. , Hagerman G.S. , Bird A.C. , Sheffield V.C. , Schorderet D.F.
Nat. Genet.22:199-202(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DHRD TRP-345;VARIANT PHE-220
16.

"Dominant radial drusen and Arg345Trp EFEMP1 mutation."
Matsumoto M. , Traboulsi E.I.
Am. J. Ophthalmol.131:810-812(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DHRD TRP-345
17.

"The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice."
Fu L. , Garland D. , Yang Z. , Shukla D. , Rajendran A. , Pearson E. , Stone E.M. , Zhang K. , Pierce E.A.
Hum. Mol. Genet.16:2411-2422(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT DHRD TRP-345

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