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Index > Protein center > Gpi(Gene name) > Mouse
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  • Gpi (Gene name),
  • Glucose-6-phosphate isomerase (Protein name ),  G6PI_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Gpi(Gpi1);
    Protein name:
    Glucose-6-phosphate isomerase(GPI);
    Alternative:
    Neuroleukin(NLK);Autocrine motility factor(AMF);Phosphohexose isomerase(PHI);Phosphoglucose isomerase(PGI);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer in the catalytically active form, monomer in the secreted form.
    Function:
    Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
    Subcellular Location:
    Cytoplasm Secreted
    Protein Attributes:
    Sequence length:
    558
    Sequence:
    50:
    MAALTRNPQF | QKLLEWHRAN | SANLKLRELF | EADPERFNNF | SLNLNTNHGH | 
    100:
    ILVDYSKNLV | NKEVMQMLVE | LAKSRGVEAA | RDNMFSGSKI | NYTENRAVLH | 
    150:
    VALRNRSNTP | IKVDGKDVMP | EVNRVLDKMK | SFCQRVRSGD | WKGYTGKSIT | 
    200:
    DIINIGIGGS | DLGPLMVTEA | LKPYSKGGPR | VWFVSNIDGT | HIAKTLASLS | 
    250:
    PETSLFIIAS | KTFTTQETIT | NAETAKEWFL | EAAKDPSAVA | KHFVALSTNT | 
    300:
    AKVKEFGIDP | QNMFEFWDWV | GGRYSLWSAI | GLSIALHVGF | DHFEQLLSGA | 
    350:
    HWMDQHFLKT | PLEKNAPVLL | ALLGIWYINC | YGCETHALLP | YDQYMHRFAA | 
    400:
    YFQQGDMESN | GKYITKSGAR | VDHQTGPIVW | GEPGTNGQHA | FYQLIHQGTK | 
    450:
    MIPCDFLIPV | QTQHPIRKGL | HHKILLANFL | AQTEALMKGK | LPEEARKELQ | 
    500:
    AAGKSPEDLE | KLLPHKVFEG | NRPTNSIVFT | KLTPFILGAL | IAMYEHKIFV | 
    550:
    QGIMWDINSF | DQWGVELGKQ | LAKKIEPELE | GSSAVTSHDS | STNGLISFIK | 
    558:
    QQRDTKLE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse GPI
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    E0725r
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    96T
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    ELISA Kit for Mouse GPI
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    E0725h
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    96T
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    ELISA Kit for Mouse GPI
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    ELISA Kit for Mouse GPI
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    E0725p
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    Packing:
    96T
    ELISA Kit for Mouse GPI
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    E0725m
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    ELISA Kit for Mouse GPI
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    E0725b
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    96T
    CLIA Kit for Mouse GPI
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    U0725p
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    96T
    CLIA Kit for Mouse GPI
    Cat.:
    U0725r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse GPI
    Cat.:
    U0725h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse GPI
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse GPI
    Cat.:
    U0725m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse GPI
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    U0725b
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    Packing:
    96T
    Polyclonal Antibody for Mouse GPI
    Cat.:
    P0725Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse GPI
    Polyclonal Antibody for Mouse GPI
    Cat.:
    P0725Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse GPI
    Polyclonal Antibody for Mouse GPI
    Polyclonal Antibody for Mouse GPI
    Cat.:
    P0725Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse GPI
    Monoclonal Antibody for Mouse GPI
    Monoclonal Antibody for Mouse GPI
    Monoclonal Antibody for Mouse GPI
    Monoclonal Antibody for Mouse GPI
    Monoclonal Antibody for Mouse GPI
    Protein for Mouse GPI
    Protein for Mouse GPI
    Protein for Mouse GPI
    Protein for Mouse GPI
    Protein for Mouse GPI
    Protein for Mouse GPI

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    References
    1. 1.
      "Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons."
      Gurney M.E. , Heinrich S.P. , Lee M.R. , Yin H.-S.
      Science234:566-574(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Salivary gland.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Bone marrow.
      tissue: Head.
      tissue: Heart.
      tissue: Olfactory bulb.
      tissue: Thymus.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    5. 5.
      Lubec G. , Klug S. , Kang S.U.
      Submitted (2007-04) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-36; 63-73; 97-104; 107-124; 148-176; 181-234; 242-252; 255-273; 424-438; 455-461 AND 467-481;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Brain.
      tissue: Hippocampus.
    6. 6.
      "Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis."
      Chu C.C. , Paul W.E.
      Mol. Immunol.35:487-502(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 235-393
      strain: BALB/c.
      tissue: Spleen.
    7. 7.
      "Identification of a novel tandemly repeated sequence present in an intron of the glucose phosphate isomerase (GPI) gene in mouse and man."
      Faik P. , Walker J.I. , Morgan M.J.
      Genomics21:122-127(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-558
    8. 8.
      "Quantitative allelic discrimination of GPI-c and GPI-a using molecular beacons."
      Bauchwitz R.P. , Tyagi S. , Marras S.A.E.
      Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 417-543
      strain: 129.
    9. 9.
      "Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences."
      Faik P. , Walker J.I.H. , Redmill A.A.M. , Morgan M.J.
      Nature332:455-456(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTITY OF NEUROLEUKIN AS PGI
    10. 10.
      "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."
      Giannakopoulos N.V. , Luo J.K. , Papov V. , Zou W. , Lenschow D.J. , Jacobs B.S. , Borden E.C. , Li J. , Virgin H.W. , Zhang D.E.
      Biochem. Biophys. Res. Commun.336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
    11. 11.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-142;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    12. 12.
      "The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening."
      Solomons J.T.G. , Zimmerly E.M. , Burns S. , Krishnamurthy N. , Swan M.K. , Krings S. , Muirhead H. , Chirgwin J. , Davies C.
      J. Mol. Biol.342:847-860(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH G6P;ACTIVE SITE
    13. 13.
      "Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide."
      Watanabe H. , Takehana K. , Date M. , Shinozaki T. , Raz A.
      Cancer Res.56:2960-2963(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTITY OF AMF AS PGI
    14. 14.
      "Crystal structures of mouse autocrine motility factor in complex with carbohydrate phosphate inhibitors provide insight into structure-activity relationship of the inhibitors."
      Tanaka N. , Haga A. , Naba N. , Shiraiwa K. , Kusakabe Y. , Hashimoto K. , Funasaka T. , Nagase H. , Raz A. , Nakamura K.T.
      J. Mol. Biol.356:312-324(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-557 IN COMPLEX WITH INHIBITORS
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