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Index > Protein center > GPRC6A(Gene name) > Human
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  • GPRC6A (Gene name),
  • G-protein coupled receptor family C group 6 member A (Protein name ),  GPC6A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GPRC6A;
    Protein name:
    G-protein coupled receptor family C group 6 member A(hGPRC6A);
    Alternative:
    G-protein coupled receptor GPCR33(hGPCR33);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritionnal and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    926
    Sequence:
    50:
    MAFLIILITC | FVIILATSQP | CQTPDDFVAA | TSPGHIIIGG | LFAIHEKMLS | 
    100:
    SEDSPRRPQI | QECVGFEISV | FLQTLAMIHS | IEMINNSTLL | PGVKLGYEIY | 
    150:
    DTCTEVTVAM | AATLRFLSKF | NCSRETVEFK | CDYSSYMPRV | KAVIGSGYSE | 
    200:
    ITMAVSRMLN | LQLMPQVGYE | STAEILSDKI | RFPSFLRTVP | SDFHQIKAMA | 
    250:
    HLIQKSGWNW | IGIITTDDDY | GRLALNTFII | QAEANNVCIA | FKEVLPAFLS | 
    300:
    DNTIEVRINR | TLKKIILEAQ | VNVIVVFLRQ | FHVFDLFNKA | IEMNINKMWI | 
    350:
    ASDNWSTATK | ITTIPNVKKI | GKVVGFAFRR | GNISSFHSFL | QNLHLLPSDS | 
    400:
    HKLLHEYAMH | LSACAYVKDT | DLSQCIFNHS | QRTLAYKANK | AIERNFVMRN | 
    450:
    DFLWDYAEPG | LIHSIQLAVF | ALGYAIRDLC | QARDCQNPNA | FQPWELLGVL | 
    500:
    KNVTFTDGWN | SFHFDAHGDL | NTGYDVVLWK | EINGHMTVTK | MAEYDLQNDV | 
    550:
    FIIPDQETKN | EFRNLKQIQS | KCSKECSPGQ | MKKTTRSQHI | CCYECQNCPE | 
    600:
    NHYTNQTDMP | HCLLCNNKTH | WAPVRSTMCF | EKEVEYLNWN | DSLAILLLIL | 
    650:
    SLLGIIFVLV | VGIIFTRNLN | TPVVKSSGGL | RVCYVILLCH | FLNFASTSFF | 
    700:
    IGEPQDFTCK | TRQTMFGVSF | TLCISCILTK | SLKILLAFSF | DPKLQKFLKC | 
    750:
    LYRPILIIFT | CTGIQVVICT | LWLIFAAPTV | EVNVSLPRVI | ILECEEGSIL | 
    800:
    AFGTMLGYIA | ILAFICFIFA | FKGKYENYNE | AKFITFGMLI | YFIAWITFIP | 
    850:
    IYATTFGKYV | PAVEIIVILI | SNYGILYCTF | IPKCYVIICK | QEINTKSAFL | 
    900:
    KMIYSYSSHS | VSSIALSPAS | LDSMSGNVTM | TNPSSSGKSA | TWQKSKDLQA | 
    926:
    QAFAHICREN | ATSVSKTLPR | KRMSSI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human hGPRC6A
    Cat.:
    E6430h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human hGPRC6A
    Cat.:
    E6430r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human hGPRC6A
    Cat.:
    E6430b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human hGPRC6A
    Cat.:
    E6430m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human hGPRC6A
    Cat.:
    U6430h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human hGPRC6A
    Cat.:
    U6430b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human hGPRC6A
    Cat.:
    U6430m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human hGPRC6A
    Cat.:
    U6430r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human hGPRC6A
    Cat.:
    P6430Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human hGPRC6A
    Cat.:
    P6430Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human hGPRC6A
    Polyclonal Antibody for Human hGPRC6A
    Cat.:
    P6430Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human hGPRC6A
    Monoclonal Antibody for Human hGPRC6A
    Monoclonal Antibody for Human hGPRC6A
    Monoclonal Antibody for Human hGPRC6A
    Protein for Human hGPRC6A
    Protein for Human hGPRC6A
    Protein for Human hGPRC6A
    Protein for Human hGPRC6A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor."
      Wellendorph P. , Braeuner-Osborne H.
      Gene335:37-46(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY;VARIANT SER-91
      tissue: Kidney.
    2. 2.
      "Cloning of a metabotropic glutamate/pheromone receptor (GPRC6A)."
      Lorenz-Depiereux B. , Dorner M. , Strom T.M.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-91
      tissue: Kidney.
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M. , Sato T. , Okouchi I. , Arita M. , Futami K. , Matsumoto S. , Tsutsumi S. , Aburatani H. , Asai K. , Akiyama Y.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-926
    5. 5.
      "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S. , Kadowaki S. , Haga T. , Takaesu H. , Mitaku S.
      FEBS Lett.520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 559-926
    6. 6.
      "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids."
      Wellendorph P. , Hansen K.B. , Balsgaard A. , Greenwood J.R. , Egebjerg J. , Brauener-Osborne H.
      Mol. Pharmacol.67:589-597(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF SER-149 AND THR-172
    7. 7.
      "GPRC6A mediates the non-genomic effects of steroids."
      Pi M. , Parrill A.L. , Quarles L.D.
      J. Biol. Chem.285:39953-39964(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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