Huwe1 ELISA Kit for Mouse(Mus musculus) | EIAab.comHuwe1 ELISA Kit for Mouse(Mus musculus)

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Huwe1 (Gene name),

E3 ubiquitin-protein ligase HUWE1 (Protein name ), HUWE1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Huwe1(Kiaa0312;Ureb1);

Protein name:

E3 ubiquitin-protein ligase HUWE1;

Alternative:

HECT, UBA and WWE domain-containing protein 1;E3Histone;Upstream regulatory element-binding protein 1(URE-B1;URE-binding protein 1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with isoform p19ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity (By similarity). Interacts with MYCN, POLB and CDC6.

Function:

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.

Subcellular Location:

Cytoplasm Nucleus Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells.

Protein Attributes:

Sequence length:

4377

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4377:

PAYESFEKLR | HMLLLAIQEC | SEGFGLA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:59026

UniGene:

Mm.27372

Pfam:

PF14377

String:

Q7TMY8

SMR:

Q7TMY8

Pfam:

PF06012

STRING:

10090.ENSMUSP00000026292

Uniprot:

Q7TMY8

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ELISA Kit for Mouse E3 ubiquitin-protein ligase HUWE1

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ELISA Kit for Mouse E3 ubiquitin-protein ligase HUWE1

Cat.:

E2369m

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96T

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ELISA Kit for Mouse E3 ubiquitin-protein ligase HUWE1

Cat.:

E2369h

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96T

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CLIA Kit for Mouse E3 ubiquitin-protein ligase HUWE1

Cat.:

U2369h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Mouse E3 ubiquitin-protein ligase HUWE1

Cat.:

U2369m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase HUWE1

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Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase HUWE1

Cat.:

P2369Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase HUWE1

Cat.:

P2369Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase HUWE1

Protein for Mouse E3 ubiquitin-protein ligase HUWE1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor."
Chen D. , Kon N. , Li M. , Zhang W. , Qin J. , Gu W.
Cell121:1071-1083(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: C57BL/6J.
2.

Chen D. , Kon N. , Li M. , Zhang W. , Qin J. , Gu W.
Submitted (2006-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 253; 1728; 2009-2010; 2032 AND 3034-3035
3.

"Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones."
Liu Z. , Oughtred R. , Wing S.S.
Mol. Cell. Biol.25:2819-2831(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
strain: C57BL/6J.
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Hara Y. , Nagase T. , Ohara O. , Koga H.
DNA Res.9:179-188(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1445-4377 (ISOFORM 1)
tissue: Embryonic intestine.
6.

Okazaki N. , Kikuno R. , Nagase T. , Ohara O. , Koga H.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
tissue: Brain.
7.

Lubec G. , Kang S.U.
Submitted (2007-04) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1627-1655; 3127-3133 AND 3245-3253;IDENTIFICATION BY MASS SPECTROMETRY
strain: C57BL/6.
tissue: Brain.
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1630-4377 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3283-4377 (ISOFORM 3)
strain: C57BL/6.
strain: FVB/N-3.
tissue: Brain.
tissue: Eye.
tissue: Mammary gland.
9.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3421-4377 (ISOFORM 4)
strain: C57BL/6J.
10.

"Mouse homolog to KIAA0312."
Seki N. , Hattori A. , Hayashi A. , Kozuma S. , Muramatsu M. , Saito T.
Submitted (1999-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4005-4377 (ISOFORMS 1/3)
11.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
12.

"Regulated expression of the ubiquitin protein ligase, E3(Histone)/LASU1/Mule/ARF-BP1/HUWE1, during spermatogenesis."
Liu Z. , Miao D. , Xia Q. , Hermo L. , Wing S.S.
Dev. Dyn.236:2889-2898(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
13.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395; SER-1907 AND SER-3810;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
14.

"The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein."
Zhao X. , Heng J.I.-T. , Guardavaccaro D. , Jiang R. , Pagano M. , Guillemot F. , Iavarone A. , Lasorella A.
Nat. Cell Biol.10:643-653(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
15.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1907;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
16.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2267;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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