Irak4 ELISA Kit for Mouse(Mus musculus) | EIAab.comIrak4 ELISA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Irak4(Gene name) > Mouse

Irak4 (Gene name),

Interleukin-1 receptor-associated kinase 4 (Protein name ), IRAK4_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Irak4;

Protein name:

Interleukin-1 receptor-associated kinase 4(IRAK-4);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome. Once phosphorylated, IRAK4 dissociates from the receptor complex and then associates with the TNF receptor-associated factor 6 (TRAF6), IRAK1, and PELI1; this intermediate complex is required for subsequent NF-kappa-B activation. Interacts with IL1RL1.

Function:

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-TAK1/NR2C2-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, TAK1/NR2C2 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

459

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

459:

QQLLQEMSA

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

Q8R4K2

UniGene:

Mm.422858

KEGG:

mmu:266632

Pfam:

PF00531

String:

Q8R4K2

Uniprot:

Q8R4K2

FOR

ELISA Kit for Mouse IRAK-4

Cat.:

E9259m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse IRAK-4

Cat.:

E9259h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Mouse IRAK-4

Cat.:

E9259b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse IRAK-4

Cat.:

U9259b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse IRAK-4

Cat.:

U9259m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse IRAK-4

Cat.:

U9259h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse IRAK-4

Cat.:

P9259Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse IRAK-4

Cat.:

P9259Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse IRAK-4

Monoclonal Antibody for Mouse IRAK-4

Protein for Mouse IRAK-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase."
Li S. , Strelow A. , Fontana E.J. , Wesche H.
Proc. Natl. Acad. Sci. U.S.A.99:5567-5572(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Skin.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Embryo.
4.

"Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4."
Suzuki N. , Suzuki S. , Duncan G.S. , Millar D.G. , Wada T. , Mirtsos C. , Takada H. , Wakeham A. , Itie A. , Li S. , Penninger J.M. , Wesche H. , Ohashi P.S. , Mak T.W. , Yeh W.C.
Nature416:750-756(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
5.

"Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1."
Choi K.C. , Lee Y.S. , Lim S. , Choi H.K. , Lee C.H. , Lee E.K. , Hong S. , Kim I.H. , Kim S.J. , Park S.H.
Nat. Immunol.7:1057-1065(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN COMPLEX WITH IRAK1; MYD88; PELI1 AND TRAF6
6.

"B cell antigen receptor-induced activation of an IRAK4-dependent signaling pathway revealed by a MALT1-IRAK4 double knockout mouse model."
Dufner A. , Schamel W.W.
Cell Commun. Signal.9:6-6(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
7.

"Molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling."
Lasker M.V. , Gajjar M.M. , Nair S.K.
J. Immunol.175:4175-4179(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1-113
8.

"Solution structure of the death domain of interleukin-1 receptor-associated kinase 4 (IRAK4) from Mus musculus."
RIKEN structural genomics initiative (RSGI)
Submitted (2004-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-114

Product Feedback Wall

* Email:
*Comments: