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Index > Protein center > Prkaca(Gene name) > Rat
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  • Prkaca (Gene name),
  • cAMP-dependent protein kinase catalytic subunit alpha (Protein name ),  KAPCA_RAT from NCBI database.
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  • General Annotation
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  • Gene name:
    Prkaca;
    Protein name:
    cAMP-dependent protein kinase catalytic subunit alpha(PKA C-alpha);
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2.
    Function:
    Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
    Subcellular Location:
    Cytoplasm Cell membrane Nucleus Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.
    Protein Attributes:
    Sequence length:
    351
    Sequence:
    50:
    MGNAAAAKKG | SEQESVKEFL | AKAKEDFLKK | WEDPSQNTAQ | LDHFDRIKTL | 
    100:
    GTGSFGRVML | VKHKESGNHY | AMKILDKQKV | VKLKQIEHTL | NEKRILQAVN | 
    150:
    FPFLVKLEFS | FKDNSNLYMV | MEYVPGGEMF | SHLRRIGRFS | EPHARFYAAQ | 
    200:
    IVLTFEYLHS | LDLIYRDLKP | ENLLIDQQGY | IQVTDFGFAK | RVKGRTWTLC | 
    250:
    GTPEYLAPEI | ILSKGYNKAV | DWWALGVLIY | EMAAGYPPFF | ADQPIQIYEK | 
    300:
    IVSGKVRFPS | HFSSDLKDLL | RNLLQVDLTK | RFGNLKNGVN | DIKNHKWFAT | 
    350:
    TDWIAIYQRK | VEAPFIPKFK | GPGDTSNFDD | YEEEEIRVSI | NEKCGKEFTE | 
    351:
    F
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat PKA C-alpha
    Cat.:
    E1918h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat PKA C-alpha
    Cat.:
    E1918m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat PKA C-alpha
    Cat.:
    E1918r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat PKA C-alpha
    Cat.:
    E1918d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat PKA C-alpha
    Cat.:
    E1918p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat PKA C-alpha
    Cat.:
    E1918b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PKA C-alpha
    Cat.:
    U1918m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PKA C-alpha
    Cat.:
    U1918r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PKA C-alpha
    Cat.:
    U1918b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PKA C-alpha
    Cat.:
    U1918d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PKA C-alpha
    Cat.:
    U1918p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PKA C-alpha
    Cat.:
    U1918h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Rat PKA C-alpha
    Polyclonal Antibody for Rat PKA C-alpha
    Cat.:
    P1918Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat PKA C-alpha
    Polyclonal Antibody for Rat PKA C-alpha
    Polyclonal Antibody for Rat PKA C-alpha
    Cat.:
    P1918Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat PKA C-alpha
    Cat.:
    P1918Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat PKA C-alpha
    Monoclonal Antibody for Rat PKA C-alpha
    Monoclonal Antibody for Rat PKA C-alpha
    Monoclonal Antibody for Rat PKA C-alpha
    Monoclonal Antibody for Rat PKA C-alpha
    Monoclonal Antibody for Rat PKA C-alpha
    Protein for Rat PKA C-alpha
    Protein for Rat PKA C-alpha
    Cat.:
    R1918h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Rat PKA C-alpha
    Cat.:
    R1918m
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Rat PKA C-alpha
    Protein for Rat PKA C-alpha
    Protein for Rat PKA C-alpha

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    Precision
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    Linearity
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    References
    1. 1.
      "Rat C alpha catalytic subunit of the cAMP-dependent protein kinase: cDNA sequence and evidence that it is the only isoform expressed in myoblasts."
      Wiemann S. , Voss H. , Kinzel V. , Pyerin W.
      Biochim. Biophys. Acta1089:254-256(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    2. 2.
      "A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry."
      Jedrzejewski P.T. , Girod A. , Tholey A. , Koenig N. , Thullner S. , Kinzel V. , Bossemeyer D.
      Protein Sci.7:457-469(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-8 (ISOFORM 1);MYRISTOYLATION AT GLY-2;DEAMIDATION AT ASN-3
    3. 3.
      "Phosphorylation of rat spermatidal protein TP2 by sperm-specific protein kinase A and modulation of its transport into the haploid nucleus."
      Ullas K.S. , Rao M.R.S.
      J. Biol. Chem.278:52673-52680(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-313 (ISOFORM 2);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      strain: Wistar.
    4. 4.
      "Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep."
      Datta S. , Desarnaud F.
      J. Neurosci.30:12263-12273(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RAPID EYE MOVEMENT SLEEP
    5. 5.
      "RAB13 regulates Sertoli cell permeability barrier dynamics through protein kinase A."
      Su W. , Liu X.
      J. Mol. Endocrinol.50:305-318(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB13
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