Maf ELISA Kit for Mouse(Mus musculus) | EIAab.comMaf ELISA Kit for Mouse(Mus musculus)

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Maf (Gene name),

Transcription factor Maf (Protein name ), MAF_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Maf(Maf2);

Protein name:

Transcription factor Maf;

Alternative:

V-maf musculoaponeurotic fibrosarcoma oncogene homolog;Proto-oncogene c-Maf;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or as a heterodimer. Heterotetramer of two MAF and two USF2. Interacts with PAX6; the interaction is direct. Interacts with MYB; interaction take place weakly in normal T cells and increases in T cells following stimulation through the TCR engagement. Interacts with MYB; the ternary complexe formed with MYB and the CD13 promoter is regulated in response to differentiating signals. Interacts with USF2; the interaction inhibits its DNA-binding activity on the L7 promoter. Interacts with CREBBP, EP300 and ETS1.

Function:

Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

370

Sequence:

50:

100:

150:

200:

250:

300:

350:

370:

NGFRENGSSS | DNPSSPEFFM |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P54843

UniGene:

Mm.275549

KEGG:

mmu:17132

SMR:

P54843

Pfam:

PF03131

Uniprot:

P54843

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ELISA Kit for Mouse Transcription factor Maf

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E1179h

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96T

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ELISA Kit for Mouse Transcription factor Maf

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E1179r

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96T

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ELISA Kit for Mouse Transcription factor Maf

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E1179m

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ELISA Kit for Mouse Transcription factor Maf

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E1179b

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96T

ELISA Kit for Mouse Transcription factor Maf

Cat.:

E1179c

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96T

CLIA Kit for Mouse Transcription factor Maf

Cat.:

U1179m

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96T

CLIA Kit for Mouse Transcription factor Maf

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U1179b

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96T

CLIA Kit for Mouse Transcription factor Maf

Cat.:

U1179h

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96T

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CLIA Kit for Mouse Transcription factor Maf

Cat.:

U1179c

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96T

CLIA Kit for Mouse Transcription factor Maf

Cat.:

U1179r

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96T

Polyclonal Antibody for Mouse Transcription factor Maf

Cat.:

P1179Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Transcription factor Maf

Cat.:

P1179Rb-h

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Polyclonal Antibody for Mouse Transcription factor Maf

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P1179Rb-m

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Monoclonal Antibody for Mouse Transcription factor Maf

Protein for Mouse Transcription factor Maf

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The maf proto-oncogene stimulates transcription from multiple sites in a promoter that directs Purkinje neuron-specific gene expression."
Kurschner C. , Morgan J.I.
Mol. Cell. Biol.15:246-254(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: BALB/c.
tissue: Cerebellum.
2.

"Mafs, Prox1, and Pax6 can regulate chicken betaB1-crystallin gene expression."
Cui W. , Tomarev S.I. , Piatigorsky J. , Chepelinsky A.B. , Duncan M.K.
J. Biol. Chem.279:11088-11095(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
strain: C57BL/6J.
tissue: Head.
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity."
Kurschner C. , Morgan J.I.
Biochem. Biophys. Res. Commun.231:333-339(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HETEROTETRAMER;INTERACTION WITH USF2;MUTAGENESIS OF LEU-334
6.

"c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation."
Hedge S.P. , Kumar A. , Kurschner C. , Shapiro L.H.
Mol. Cell. Biol.18:2729-2737(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ETS1 AND MYB
7.

"The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines."
Kim J.I. , Ho I.-C. , Grusby M.J. , Glimcher L.H.
Immunity10:745-751(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
8.

"Regulation of lens fiber cell differentiation by transcription factor c-Maf."
Kawauchi S. , Takahashi S. , Nakajima O. , Ogino H. , Morita M. , Nishizawa M. , Yasuda K. , Yamamoto M.
J. Biol. Chem.274:19254-19260(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
9.

"Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development."
Kim J.I. , Li T. , Ho I.C. , Grusby M.J. , Glimcher L.H.
Proc. Natl. Acad. Sci. U.S.A.96:3781-3785(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
10.

"Regulation of mouse lens fiber cell development and differentiation by the Maf gene."
Ring B.Z. , Cordes S.P. , Overbeek P.A. , Barsh G.S.
Development127:307-317(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
11.

"CREB-binding protein/p300 co-activation of crystallin gene expression."
Chen Q. , Dowhan D.H. , Liang D. , Moore D.D. , Overbeek P.A.
J. Biol. Chem.277:24081-24089(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CREBBP AND EP300
12.

"Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development."
MacLean H.E. , Kim J.I. , Glimcher M.J. , Wang J. , Kronenberg H.M. , Glimcher L.H.
Dev. Biol.262:51-63(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
13.

"Developmental contribution of c-maf in the kidney: distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knockout mice kidney and liver."
Imaki J. , Tsuchiya K. , Mishima T. , Onodera H. , Kim J.I. , Yoshida K. , Ikeda H. , Sakai M.
Biochem. Biophys. Res. Commun.320:1323-1327(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
14.

"c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells."
Peng S. , Lalani S. , Leavenworth J.W. , Ho I.-C. , Pauza M.E.
Eur. J. Immunol.37:2868-2880(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MYB
15.

"CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element."
Mahoney K.M. , Petrovic N. , Schacke W. , Shapiro L.H.
Gene403:178-187(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF SER-15 AND SER-70;DNA-BINDING;TISSUE SPECIFICITY
16.

"Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression."
Gosmain Y. , Avril I. , Mamin A. , Philippe J.
J. Biol. Chem.282:35024-35034(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH PAX6;DNA-BINDING;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
17.

"A new MAFia in cancer."
Eychene A. , Rocques N. , Pouponnot C.
Nat. Rev. Cancer8:683-693(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;FUNCTION

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