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Index > Protein center > Mbtps1(Gene name) > Mouse
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  • Mbtps1 (Gene name),
  • Membrane-bound transcription factor site-1 protease (Protein name ),  MBTP1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mbtps1(S1p;Ski1);
    Protein name:
    Membrane-bound transcription factor site-1 protease;
    Alternative:
    Sterol-regulated luminal protease;Endopeptidase S1P;Subtilisin/kexin isozyme 1(SKI-1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein May sort to other organelles, including lysosomal and/or endosomal compartments.
    Protein Attributes:
    Sequence length:
    1052
    Sequence:
    50:
    MKLVSTWLLV | LVVLLCGKRH | LGDRLGTRAL | EKAPCPSCSH | LTLKVEFSST | 
    100:
    VVEYEYIVAF | NGYFTAKARN | SFISSALKSS | EVENWRIIPR | NNPSSDYPSD | 
    150:
    FEVIQIKEKQ | KAGLLTLEDH | PNIKRVTPQR | KVFRSLKFAE | SNPIVPCNET | 
    200:
    RWSQKWQSSR | PLKRASLSLG | SGFWHATGRH | SSRRLLRAIP | RQVAQTLQAD | 
    250:
    VLWQMGYTGA | NVRVAVFDTG | LSEKHPHFKN | VKERTNWTNE | RTLDDGLGHG | 
    300:
    TFVAGVIASM | RECQGFAPDA | ELHIFRVFTN | NQVSYTSWFL | DAFNYAILKK | 
    350:
    MDVLNLSIGG | PDFMDHPFVD | KVWELTANNV | IMVSAIGNDG | PLYGTLNNPA | 
    400:
    DQMDVIGVGG | IDFEDNIARF | SSRGMTTWEL | PGGYGRVKPD | IVTYGAGVRG | 
    450:
    SGVKGGCRAL | SGTSVASPVV | AGAVTLLVST | VQKRELVNPA | SVKQALIASA | 
    500:
    RRLPGVNMFE | QGHGKLDLLR | AYQILSSYKP | QASLSPSYID | LTECPYMWPY | 
    550:
    CSQPIYYGGM | PTIVNVTILN | GMGVTGRIVD | KPEWRPYLPQ | NGDNIEVAFS | 
    600:
    YSSVLWPWSG | YLAISISVTK | KAASWEGIAQ | GHIMITVASP | AETELHSGAE | 
    650:
    HTSTVKLPIK | VKIIPTPPRS | KRVLWDQYHN | LRYPPGYFPR | DNLRMKNDPL | 
    700:
    DWNGDHVHTN | FRDMYQHLRS | MGYFVEVLGA | PFTCFDATQY | GTLLLVDSEE | 
    750:
    EYFPEEIAKL | RRDVDNGLSL | VIFSDWYNTS | VMRKVKFYDE | NTRQWWMPDT | 
    800:
    GGANIPALNE | LLSVWNMGFS | DGLYEGEFVL | ANHDMYYASG | CSIAKFPEDG | 
    850:
    VVITQTFKDQ | GLEVLKQETA | VVENVPILGL | YQIPSEGGGR | IVLYGDSNCL | 
    900:
    DDSHRQKDCF | WLLDALLQYT | SYGVTPPSLS | HSGNRQRPPS | GAGLAPPERM | 
    950:
    EGNHLHRYSK | VLEAHLGDPK | PRPLPACPHL | SWAKPQPLNE | TAPSNLWKHQ | 
    1000:
    KLLSIDLDKV | VLPNFRSNRP | QVRPLSPGES | GAWDIPGGIM | PGRYNQEVGQ | 
    1050:
    TIPVFAFLGA | MVALAFFVVQ | ISKAKSRPKR | RRPRAKRPQL | AQQAHPARTP | 
    1052:
    SV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    KEGG:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Membrane-bound transcription factor site-1 protease
    Cat.:
    E10827h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Membrane-bound transcription factor site-1 protease
    Cat.:
    E10827m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Membrane-bound transcription factor site-1 protease
    Cat.:
    E10827r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Membrane-bound transcription factor site-1 protease
    Cat.:
    U10827r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Membrane-bound transcription factor site-1 protease
    Cat.:
    U10827m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Membrane-bound transcription factor site-1 protease
    Cat.:
    U10827h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Membrane-bound transcription factor site-1 protease
    Cat.:
    P10827Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Membrane-bound transcription factor site-1 protease
    Cat.:
    P10827Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Membrane-bound transcription factor site-1 protease
    Cat.:
    P10827Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Membrane-bound transcription factor site-1 protease
    Monoclonal Antibody for Mouse Membrane-bound transcription factor site-1 protease
    Monoclonal Antibody for Mouse Membrane-bound transcription factor site-1 protease
    Protein for Mouse Membrane-bound transcription factor site-1 protease
    Protein for Mouse Membrane-bound transcription factor site-1 protease
    Protein for Mouse Membrane-bound transcription factor site-1 protease

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Mammalian subtilisin/kexin isozyme SKI-1: a widely expressed proprotein convertase with a unique cleavage specificity and cellular localization."
      Seidah N.G. , Mowla S.J. , Hamelin J. , Mamarbachi A.M. , Benjannet S. , Toure B.B. , Basak A. , Munzer J.S. , Marcinkiewicz J. , Zhong M. , Barale J.-C. , Lazure C. , Murphy R.A. , Chretien M. , Marcinkiewicz M.
      Proc. Natl. Acad. Sci. U.S.A.96:1321-1326(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION
      tissue: Pituitary.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Skin.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      strain: NMRI.
      tissue: Mammary gland.
      tissue: Retina.
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