Mapk1 ELISA Kit for Mouse(Mus musculus) | EIAab.comMapk1 ELISA Kit for Mouse(Mus musculus)

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Mapk1 (Gene name),

Mitogen-activated protein kinase 1 (Protein name ), MK01_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapk1(Erk2;Mapk;Prkm1);

Protein name:

Mitogen-activated protein kinase 1(MAP kinase 1;MAPK 1);

Alternative:

Extracellular signal-regulated kinase 2(ERK-2);ERT1;Mitogen-activated protein kinase 2(MAP kinase 2;MAPK 2);MAP kinase isoform p42(p42-MAPK);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with ARHGEF2, HSF4 and NISCH (By similarity). Interacts with MORG1. Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with ARRB2 (By similarity). Interacts with ADAM15 (By similarity). Interacts with NEK2.

Function:

Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2), heat shock factor protein 4 (HSF4) and ARHGEF2 (By similarity). Phosphorylates SPZ1.

Subcellular Location:

Nucleus Cytoplasm cytoskeleton centrosome

Protein Attributes:

Sequence length:

358

Sequence:

50:

100:

150:

200:

250:

300:

350:

358:

RFQPGYRS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P63085

UniGene:

Mm.196581

String:

P63085

Pfam:

PF00069

KEGG:

mmu:26413

Uniprot:

P63085

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ELISA Kit for Mouse MAP kinase 1

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E1206m

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96T

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ELISA Kit for Mouse MAP kinase 1

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E1206r

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96T

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ELISA Kit for Mouse MAP kinase 1

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E1206h

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ELISA Kit for Mouse MAP kinase 1

Cat.:

E1206b

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96T

CLIA Kit for Mouse MAP kinase 1

Cat.:

U1206h

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CLIA Kit for Mouse MAP kinase 1

Cat.:

U1206m

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96T

CLIA Kit for Mouse MAP kinase 1

Cat.:

U1206r

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96T

CLIA Kit for Mouse MAP kinase 1

Cat.:

U1206b

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96T

Polyclonal Antibody for Mouse MAP kinase 1

Cat.:

P1206Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 1

Cat.:

P1206Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 1

Cat.:

P1206Rb-r

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40ug/0.2ml

Monoclonal Antibody for Mouse MAP kinase 1

Protein for Mouse MAP kinase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation."
Her J.-H. , Wu J.-S. , Rall T.B. , Sturgill T.W. , Weber M.J.
Nucleic Acids Res.19:3743-3743(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Swiss.
tissue: Fibroblast.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Brain.
tissue: Head.
tissue: Thymus.
tissue: Urinary bladder.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Eye.
4.

Lubec G. , Klug S. , Kang S.U. , Sunyer B. , Chen W.-Q.
Submitted (2009-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 54-65; 76-89; 137-162; 171-189; 193-201 AND 260-268;IDENTIFICATION BY MASS SPECTROMETRY
strain: C57BL/6.
strain: OF1.
tissue: Brain.
tissue: Hippocampus.
5.

"Novel CDC2-related protein kinases produced in murine hematopoietic stem cells."
Ershler M.A. , Nagorskaya T.V. , Visser J.W.M. , Belyavsky A.V.
Gene124:305-306(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-190
strain: CBA.
tissue: Bone marrow.
6.

"Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)."
Payne D.M. , Rossomando A.J. , Martino P. , Erickson A.K. , Her J.-H. , Shabanowitz J. , Hunt D.F. , Weber M.J. , Sturgill T.W.
EMBO J.10:885-892(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-183 AND TYR-185;PARTIAL PROTEIN SEQUENCE
7.

"Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells."
Zhang S. , Mantel C. , Broxmeyer H.E.
J. Leukoc. Biol.65:372-380(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING
8.

"Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways."
Mizuki M. , Fenski R. , Halfter H. , Matsumura I. , Schmidt R. , Muller C. , Gruning W. , Kratz-Albers K. , Serve S. , Steur C. , Buchner T. , Kienast J. , Kanakura Y. , Berdel W.E. , Serve H.
Blood96:3907-3914(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING
9.

"Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells."
Ku H. , Meier K.E.
J. Biol. Chem.275:11333-11340(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PXN
10.

"PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase."
Formstecher E. , Ramos J.W. , Fauquet M. , Calderwood D.A. , Hsieh J.C. , Canton B. , Nguyen X.T. , Barnier J.V. , Camonis J. , Ginsberg M.H. , Chneiweiss H.
Dev. Cell1:239-250(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PEA15;SUBCELLULAR LOCATION;FUNCTION OF THE MAPK ERK CASCADE
11.

"Molecular interpretation of ERK signal duration by immediate early gene products."
Murphy L.O. , Smith S. , Chen R.H. , Fingar D.C. , Blenis J.
Nat. Cell Biol.4:556-564(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF FOS;SUBCELLULAR LOCATION
12.

"Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists."
Vomastek T. , Schaeffer H.-J. , Tarcsafalvi A. , Smolkin M.E. , Bissonette E.A. , Weber M.J.
Proc. Natl. Acad. Sci. U.S.A.101:6981-6986(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MORG1
13.

"bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis."
Hsu S.-H. , Hsieh-Li H.-M. , Huang H.-Y. , Huang P.-H. , Li H.
Cancer Res.65:4041-4050(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION OF SPZ1
14.

"Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties."
Parra J.L. , Buxade M. , Proud C.G.
J. Biol. Chem.280:37623-37633(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MKNK2
15.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-183 AND TYR-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
16.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-183 AND TYR-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
17.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-183 AND TYR-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
18.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-183 AND TYR-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
19.

"Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling."
Arora D. , Stopp S. , Bohmer S.A. , Schons J. , Godfrey R. , Masson K. , Razumovskaya E. , Ronnstrand L. , Tanzer S. , Bauer R. , Bohmer F.D. , Muller J.P.
J. Biol. Chem.286:10918-10929(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING
20.

"The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions."
Yoon S. , Seger R.
Growth Factors24:21-44(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
21.

"The ERK signaling cascade--views from different subcellular compartments."
Yao Z. , Seger R.
BioFactors35:407-416(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;REVIEW ON SUBCELLULAR LOCATION
22.

"The ERK cascade: distinct functions within various subcellular organelles."
Wortzel I. , Seger R.
Genes Cancer2:195-209(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
23.

"ISG15 modulates development of the erythroid lineage."
Maragno A.L. , Pironin M. , Alcalde H. , Cong X. , Knobeloch K.P. , Tangy F. , Zhang D.E. , Ghysdael J. , Quang C.T.
PLoS ONE6:E26068-E26068(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION

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