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Index > Protein center > NASP(Gene name) > Human
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  • NASP (Gene name),
  • Nuclear autoantigenic sperm protein (Protein name ),  NASP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    NASP;
    Protein name:
    Nuclear autoantigenic sperm protein(NASP);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to linker H1 histones but not to core histones. Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T.
    Function:
    Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    788
    Sequence:
    50:
    MAMESTATAA | VAAELVSADK | IEDVPAPSTS | ADKVESLDVD | SEAKKLLGLG | 
    100:
    QKHLVMGDIP | AAVNAFQEAA | SLLGKKYGET | ANECGEAFFF | YGKSLLELAR | 
    150:
    MENGVLGNAL | EGVHVEEEEG | EKTEDESLVE | NNDNIDEEAR | EELREQVYDA | 
    200:
    MGEKEEAKKT | EDKSLAKPET | DKEQDSEMEK | GGREDMDISK | SAEEPQEKVD | 
    250:
    LTLDWLTETS | EEAKGGAAPE | GPNEAEVTSG | KPEQEVPDAE | EEKSVSGTDV | 
    300:
    QEECREKGGQ | EKQGEVIVSI | EEKPKEVSEE | QPVVTLEKQG | TAVEVEAESL | 
    350:
    DPTVKPVDVG | GDEPEEKVVT | SENEAGKAVL | EQLVGQEVPP | AEESPEVTTE | 
    400:
    AAEASAVEAG | SEVSEKPGQE | APVLPKDGAV | NGPSVVGDQT | PIEPQTSIER | 
    450:
    LTETKDGSGL | EEKVRAKLVP | SQEETKLSVE | ESEAAGDGVD | TKVAQGATEK | 
    500:
    SPEDKVQIAA | NEETQEREEQ | MKEGEETEGS | EEDDKENDKT | EEMPNDSVLE | 
    550:
    NKSLQENEEE | EIGNLELAWD | MLDLAKIIFK | RQETKEAQLY | AAQAHLKLGE | 
    600:
    VSVESENYVQ | AVEEFQSCLN | LQEQYLEAHD | RLLAETHYQL | GLAYGYNSQY | 
    650:
    DEAVAQFSKS | IEVIENRMAV | LNEQVKEAEG | SSAEYKKEIE | ELKELLPEIR | 
    700:
    EKIEDAKESQ | RSGNVAELAL | KATLVESSTS | GFTPGGGGSS | VSMIASRKPT | 
    750:
    DGASSSNCVT | DISHLVRKKR | KPEEESPRKD | DAKKAKQEPE | VNGGSGDAVP | 
    788:
    SGNEVSENME | EEAENQAESR | AAVEGTVEAG | ATVESTAC
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human NASP
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    ELISA Kit for Human NASP
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    ELISA Kit for Human NASP
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    E9778r
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    ELISA Kit for Human NASP
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    ELISA Kit for Human NASP
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    CLIA Kit for Human NASP
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    CLIA Kit for Human NASP
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    CLIA Kit for Human NASP
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    CLIA Kit for Human NASP
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    U9778h
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    CLIA Kit for Human NASP
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    Polyclonal Antibody for Human NASP
    Polyclonal Antibody for Human NASP
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    P9778Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NASP
    Polyclonal Antibody for Human NASP
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    Polyclonal Antibody for Human NASP
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NASP
    Monoclonal Antibody for Human NASP
    Monoclonal Antibody for Human NASP
    Monoclonal Antibody for Human NASP
    Monoclonal Antibody for Human NASP
    Protein for Human NASP
    Protein for Human NASP
    Protein for Human NASP
    Protein for Human NASP
    Protein for Human NASP

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein."
      O'Rand M.G. , Richardson R.T. , Zimmerman L.J. , Widgren E.E.
      Dev. Biol.154:37-44(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Testis.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-635 (ISOFORM 3)
      tissue: Placenta.
      tissue: Teratocarcinoma.
    3. 3.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Liver.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Eye.
      tissue: Lung.
      tissue: Placenta.
      tissue: Testis.
    7. 7.
      "Histone-binding domains in a human nuclear autoantigenic sperm protein."
      Batova I. , O'Rand M.G.
      Biol. Reprod.54:1238-1244(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HISTONE-BINDING REGIONS
    8. 8.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-451; SER-503 AND SER-726;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-464;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-244; THR-390; SER-408 AND THR-683;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    13. 13.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    14. 14.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-33;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-123; SER-127; SER-189; SER-451; THR-490; SER-497 AND SER-503;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-138 AND SER-141 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-123; SER-127; SER-189; SER-244; SER-299; SER-321; THR-390; SER-408; SER-421; SER-451; THR-464; THR-477; SER-480; THR-490; SER-497; SER-503; SER-726 AND SER-751;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-138 AND SER-141 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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