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Index > Protein center > Nasp(Gene name) > Mouse
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  • Nasp (Gene name),
  • Nuclear autoantigenic sperm protein (Protein name ),  NASP_MOUSE from NCBI database.
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  • Gene name:
    Nasp;
    Protein name:
    Nuclear autoantigenic sperm protein(NASP);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds to linker H1 histones but not to core histones. Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T.
    Function:
    Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and linker H1 histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    773
    Sequence:
    50:
    MATESTAAAA | IAAELVSADK | IEDAPAPSTS | ADKMESLDVD | SEAKKLLGLG | 
    100:
    QKHLVMGDIP | AAVNAFQEAA | SLLGKKYGET | ANECGEAFFF | YGKSLLELAR | 
    150:
    MENGVLGNAL | EGVHVEEEEG | EKTEDESLVE | NNDNVDEEAR | EELREQVYDA | 
    200:
    MGEKEAKKAE | GKSLTKPETD | KEQESEVEKG | GREDMDISEP | EEKLQETVEP | 
    250:
    TSKQLTESSE | EAKEAAIPGL | NEDEVASGKT | EQESLCTEKG | KSISGAYVQN | 
    300:
    KEFRETVEEG | EEIISLEKKP | KETSEDQPIR | AAEKQGTLMK | VVEIEAEIDP | 
    350:
    QVKSADVGGE | EPKDQVATSE | SELGKAVLME | LSGQDVEASP | VVAAEAGAEV | 
    400:
    SEKPGQEITV | IPNNGPVVGQ | STVGDQTPSE | PQTSAERLTE | TKDGSSVEEV | 
    450:
    KAELVPEQEE | AMLPVEESEA | AGDGVETKVA | QKATEKAPED | KFKIAANEET | 
    500:
    PERDEQMKEG | EETEGSEEED | RENDKAEETP | NESVLEKKSL | QENEEEEIGN | 
    550:
    LELAWDMLDL | AKIIFKRQET | KEAQLYAAQA | HLKLGEVSVE | SENYIQAVEE | 
    600:
    FQACLSLQEQ | YLEAHDRLLA | ETHYQLGLAY | GYNSQYDEAV | AQFGKSIDVI | 
    650:
    EKRMAVLHEQ | MKEAEGSFTE | YEKEIEELKE | LLPEIREKIE | DAKESQRSGN | 
    700:
    VAELALKATL | VESSTSGFTP | SGAGASVSMI | ASRKPTDGAS | SSNCVTDISH | 
    750:
    LVRKKRKPEE | ESPRKDDAKK | AKQEPEVNGG | SGDAVSSGKE | VSENMEAEAE | 
    773:
    NQAESQTAEG | TVESAATIKS | TAC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
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    ELISA Kit for Mouse NASP
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    ELISA Kit for Mouse NASP
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    CLIA Kit for Mouse NASP
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    CLIA Kit for Mouse NASP
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    96T
    CLIA Kit for Mouse NASP
    Cat.:
    U9778r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse NASP
    Cat.:
    U9778h
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    CLIA Kit for Mouse NASP
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    MSDS:
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    Polyclonal Antibody for Mouse NASP
    Polyclonal Antibody for Mouse NASP
    Cat.:
    P9778Rb-r
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    Packing:
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    Polyclonal Antibody for Mouse NASP
    Polyclonal Antibody for Mouse NASP
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    Polyclonal Antibody for Mouse NASP
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    Packing:
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    Monoclonal Antibody for Mouse NASP
    Monoclonal Antibody for Mouse NASP
    Monoclonal Antibody for Mouse NASP
    Monoclonal Antibody for Mouse NASP
    Monoclonal Antibody for Mouse NASP
    Protein for Mouse NASP
    Protein for Mouse NASP
    Protein for Mouse NASP
    Protein for Mouse NASP
    Protein for Mouse NASP

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein."
      Richardson R.T. , Batova I.N. , Widgren E.E. , Zheng L.-X. , Whitfield M. , Marzluff W.F. , O'Rand M.G.
      J. Biol. Chem.275:30378-30386(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);INTERACTION WITH HISTONES;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      strain: BALB/c.
      tissue: Ovary.
      tissue: Spleen.
      tissue: Testis.
    2. 2.
      "Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation."
      Richardson R.T. , Alekseev O.M. , Grossman G. , Widgren E.E. , Thresher R. , Wagner E.J. , Sullivan K.D. , Marzluff W.F. , O'Rand M.G.
      J. Biol. Chem.281:21526-21534(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2);FUNCTION;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE
      strain: 129/SvJ.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-453 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Testis.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: FVB/N.
      tissue: Mammary gland.
    5. 5.
      "Overexpression of the linker histone-binding protein tNASP affects progression through the cell cycle."
      Alekseev O.M. , Bencic D.C. , Richardson R.T. , Widgren E.E. , O'Rand M.G.
      J. Biol. Chem.278:8846-8852(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH HISTONES
    6. 6.
      "Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei."
      Alekseev O.M. , Widgren E.E. , Richardson R.T. , O'Rand M.G.
      J. Biol. Chem.280:2904-2911(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HIST1H1T AND HSP90
    7. 7.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-241; LYS-251 AND LYS-284;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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