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Index > Protein center > NFAM1(Gene name) > Human
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  • NFAM1 (Gene name),
  • NFAT activation molecule 1 (Protein name ),  NFAM1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    NFAM1(CNAIP);
    Protein name:
    NFAT activation molecule 1;
    Alternative:
    NFAT-activating protein with ITAM motif 1;Calcineurin/NFAT-activating ITAM-containing protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ZAP70 and SYK. No direct interaction with the B-cell antigen receptor (BCR).
    Function:
    May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Partially recruited to lipid rafts upon BCR stimulation.
    Protein Attributes:
    Sequence length:
    270
    Sequence:
    50:
    MENQPVRWRA | LPGLPRPPGL | PAAPWLLLGV | LLLPGTLRLA | GGQSVTHTGL | 
    100:
    PIMASLANTA | ISFSCRITYP | YTPQFKVFTV | SYFHEDLQGQ | RSPKKPTNCH | 
    150:
    PGLGTENQSH | TLDCQVTLVL | PGASATGTYY | CSVHWPHSTV | RGSGTFILVR | 
    200:
    DAGYREPPQS | PQKLLLFGFT | GLLSVLSVVG | TALLLWNKKR | MRGPGKDPTR | 
    250:
    KCPDPRSASS | PKQHPSESVY | TALQRRETEV | YACIENEDGS | SPTAKQSPLS | 
    270:
    QERPHRFEDD | GELNLVYENL | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human NFAT activation molecule 1
    Cat.:
    E3904m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human NFAT activation molecule 1
    Cat.:
    E3904h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human NFAT activation molecule 1
    Cat.:
    U3904m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NFAT activation molecule 1
    Cat.:
    U3904h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human NFAT activation molecule 1
    Cat.:
    P3904Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NFAT activation molecule 1
    Cat.:
    P3904Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NFAT activation molecule 1
    Monoclonal Antibody for Human NFAT activation molecule 1
    Protein for Human NFAT activation molecule 1
    Protein for Human NFAT activation molecule 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway."
      Yang J. , Hu G. , Wang S.W. , Li Y. , Martin R. , Li K. , Yao Z.
      J. Biol. Chem.278:16797-16801(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF TYR-220 AND TYR-231
    2. 2.
      "NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling."
      Ohtsuka M. , Arase H. , Takeuchi A. , Yamasaki S. , Shiina R. , Suenaga T. , Sakurai D. , Yokosuka T. , Arase N. , Iwashima M. , Kitamura T. , Moriya H. , Saito T.
      Proc. Natl. Acad. Sci. U.S.A.101:8126-8131(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;GLYCOSYLATION;INTERACTION WITH SYK AND ZAP70;MUTAGENESIS OF TYR-220 AND TYR-231
      tissue: T-cell.
    3. 3.
      "A genome annotation-driven approach to cloning the human ORFeome."
      Collins J.E. , Wright C.L. , Edwards C.A. , Davis M.P. , Grinham J.A. , Cole C.G. , Goward M.E. , Aguado B. , Mallya M. , Mokrab Y. , Huckle E.J. , Beare D.M. , Dunham I.
      Submitted (2006-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H. , Takano J. , Kikuno R. , Hirosawa M. , Nagase T. , Nomura N. , Ohara O.
      DNA Res.10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-270
      tissue: Spleen.
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