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Index > Protein center > Ret(Gene name) > Mouse
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  • Ret (Gene name),
  • Proto-oncogene tyrosine-protein kinase receptor Ret (Protein name ),  RET_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ret;
    Protein name:
    Proto-oncogene tyrosine-protein kinase receptor Ret;
    Alternative:
    Proto-oncogene c-Ret;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Phosphorylated form interacts with the PBT domain of DOK2, DOK4 and DOK5. The phosphorylated form interacts with PLCG1 and GRB7.
    Function:
    Probable receptor with tyrosine-protein kinase activity; important for development.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1115
    Sequence:
    50:
    MAKATSGAAG | LGLKLILLLP | LLGEAPLGLY | FSRDAYWERL | YVDQPAGTPL | 
    100:
    LYVHALRDAP | GEVPSFRLGQ | HLYGVYRTRL | HENDWIRINE | TTGLLYLNQS | 
    150:
    LDHSSWEQLS | IRNGGFPLLT | IFLQVFLGST | AQREGECHWP | GCTRVYFSFI | 
    200:
    NDTFPNCSSF | KAQDLCIPET | AVSFRVRENR | PPGTFYHFHM | LPVQFLCPNI | 
    250:
    SVKYSLLGGD | SLPFRCDPDC | LEVSTRWALD | RELREKYVLE | ALCIVAGPGA | 
    300:
    NKETVTLSFP | VTVYDEDDSA | PTFSGGVGTA | SAVVEFKRKE | GTVVATLQVF | 
    350:
    DADVVPASGE | LVRRYTNTLL | SGDSWAQQTF | RVEHSPIETL | VQVNNNSVRA | 
    400:
    TMHNYKLILN | RSLSISESRV | LQLAVLVNDS | DFQGPGAGGI | LVLHFNVSVL | 
    450:
    PVTLNLPRAY | SFPVNKRARR | YAQIGKVCVE | NCQEFSGVSI | QYKLQPSSIN | 
    500:
    CTALGVVTSP | EDTSGTLFVN | DTEALRRPEC | TKLQYTVVAT | DRQTRRQTQA | 
    550:
    SLVVTVEGTS | ITEEVGCPKS | CAVNKRRPEC | EECGGLGSPT | GRCEWRQGDG | 
    600:
    KGITRNFSTC | SPSTRTCPDG | HCDAVESRDA | NICPQDCLRA | DIVGGHERGE | 
    650:
    RQGIKAGYGI | CNCFPDEKKC | FCEPEDSQGP | LCDALCRTII | TAALFSLIIS | 
    700:
    ILLSIFCVCH | HHKHGHKPPI | ASAEMTFCRP | AQGFPISYSS | SGTRRPSLDS | 
    750:
    TENQVPVDSF | KIPEDPKWEF | PRKNLVLGKT | LGEGEFGKVV | KATAFRLKGR | 
    800:
    AGYTTVAVKM | LKENASQSEL | RDLLSEFNLL | KQVNHPHVIK | LYGACSQDGP | 
    850:
    LLLIVEYAKY | GSLRGFLRDS | RKIGPAYVSG | GGSRNSSSLD | HPDERVLTMG | 
    900:
    DLISFAWQIS | RGMQYLAEMK | LVHRDLAARN | ILVAEGRKMK | ISDFGLSRDV | 
    950:
    YEEDSYVKKS | KGRIPVKWMA | IESLFDHIYT | TQSDVWSFGV | LLWEIVTLGG | 
    1000:
    NPYPGIPPER | LFNLLKTGHR | MERPDNCSEE | MYRLMLQCWK | QEPDKRPVFA | 
    1050:
    DISKDLEKMM | VKSRDYLDLA | ASTPSDSLLY | DDGLSEEETP | LVDCNNAPLP | 
    1100:
    RSLPSTWIEN | KLYGMSDPNW | PGESPVPLTR | ADGTSTGFPR | YANDSVYANW | 
    1115:
    MVSPSAAKLM | DTFDS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Cat.:
    E15070h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Cat.:
    E15070r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Cat.:
    U15070h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Polyclonal Antibody for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Polyclonal Antibody for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Monoclonal Antibody for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Monoclonal Antibody for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Monoclonal Antibody for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Protein for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Protein for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret
    Protein for Mouse Proto-oncogene tyrosine-protein kinase receptor Ret

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily."
      Iwamoto T. , Taniguchi M. , Asai N. , Ohkusu K. , Nakashima I. , Takahashi M.
      Oncogene8:1087-1091(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Molecular characterization of mouse neuro-2a c-ret proto-oncogene."
      Phua C.Y.D. , Too H.P.
      Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      Wang Y.-Z. , Yoong L.-F. , Too H.-P.
      Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: BALB/c.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Spinal ganglion.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      "Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7."
      Pandey A. , Liu X. , Dixon J.E. , Di Fiore P.P. , Dixit V.M.
      J. Biol. Chem.271:10607-10610(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB7 AND PLCG1
    7. 7.
      "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation."
      Grimm J. , Sachs M. , Britsch S. , Di Cesare S. , Schwarz-Romond T. , Alitalo K. , Birchmeier W.
      J. Cell Biol.154:345-354(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOK2; DOK4 AND DOK5;PHOSPHORYLATION;MUTAGENESIS OF TYR-1063
    8. 8.
      "Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis."
      Veiga-Fernandes H. , Coles M.C. , Foster K.E. , Patel A. , Williams A. , Natarajan D. , Barlow A. , Pachnis V. , Kioussis D.
      Nature446:547-551(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PEYER'S PATCH ORGANOGENESIS;INTERACTION WITH ARTN
    9. 9.
      "CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction."
      Tsui C.C. , Pierchala B.A.
      J. Neurosci.28:8789-8800(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RET;TISSUE SPECIFICITY
    10. 10.
      "RET signaling is required for survival and normal function of nonpeptidergic nociceptors."
      Golden J.P. , Hoshi M. , Nassar M.A. , Enomoto H. , Wood J.N. , Milbrandt J. , Gereau R.W. IV , Johnson E.M. Jr. , Jain S.
      J. Neurosci.30:3983-3994(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NOCICEPTORS REGULATION;DISRUPTION PHENOTYPE
    11. 11.
      "A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo."
      Samadi A.K. , Mukerji R. , Shah A. , Timmermann B.N. , Cohen M.S.
      Surgery148:1228-1236(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    12. 12.
      "Structural basis for the specific recognition of RET by the Dok1 phosphotyrosine binding domain."
      Shi N. , Ye S. , Bartlam M. , Yang M. , Wu J. , Liu Y. , Sun F. , Han X. , Peng X. , Qiang B. , Yuan J. , Rao Z.
      J. Biol. Chem.279:4962-4969(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 1055-1067;PHOSPHORYLATION AT TYR-1063
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