RUNX1 ELISA Kit for Human(Homo sapiens) | EIAab.comRUNX1 ELISA Kit for Human(Homo sapiens)

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RUNX1 (Gene name),

Runt-related transcription factor 1 (Protein name ), RUNX1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RUNX1(AML1;CBFA2);

Protein name:

Runt-related transcription factor 1;

Alternative:

Core-binding factor subunit alpha-2(CBF-alpha-2);Acute myeloid leukemia 1 protein;Polyomavirus enhancer-binding protein 2 alpha B subunit(PEA2-alpha B;PEBP2-alpha B);Oncogene AML-1;SL3/AKV core-binding factor alpha B subunit;SL3-3 enhancer factor 1 alpha B subunit;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with MYST3 and MYST4. Interacts with SUV39H1, leading to abrogation of transactivating and DNA-binding properties of RUNX1. Interacts with YAP1. Interacts with HIPK2 (By similarity). Interaction with CDK6 prevents myeloid differentiation, reducing its transcription transactivation activity.

Function:

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

453

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

453:

RPY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

151385

KEGG:

hsa:861

UniGene:

Hs.149261

Pfam:

PF00853

SMR:

Q01196

String:

Q01196

Uniprot:

Q01196

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ELISA Kit for Human Runt-related transcription factor 1

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E10487h

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96T

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ELISA Kit for Human Runt-related transcription factor 1

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E10487m

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ELISA Kit for Human Runt-related transcription factor 1

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E10487r

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96T

CLIA Kit for Human Runt-related transcription factor 1

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U10487m

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96T

CLIA Kit for Human Runt-related transcription factor 1

Cat.:

U10487h

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96T

CLIA Kit for Human Runt-related transcription factor 1

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U10487r

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Polyclonal Antibody for Human Runt-related transcription factor 1

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P10487Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Runt-related transcription factor 1

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P10487Rb-r

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Polyclonal Antibody for Human Runt-related transcription factor 1

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P10487Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human Runt-related transcription factor 1

Protein for Human Runt-related transcription factor 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

Ahn M.-Y. , Bae S.C. , Zhang Y.W. , Shigesada K. , Ito Y.
Submitted (1994-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1."
Miyoshi H. , Shimizu K. , Kozu T. , Maseki N. , Kaneko Y. , Ohki M.
Proc. Natl. Acad. Sci. U.S.A.88:10431-10434(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM AML-1C)
tissue: Leukocyte.
3.

"AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts."
Sacchi N. , Nisson P.E. , Watkins P.C. , Faustinella F. , Wijsman J. , Hagemeijer A.
Genes Chromosomes Cancer11:226-236(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE PRODUCTS;CHROMOSOMAL TRANSLOCATION WITH EAP
4.

"Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis."
Nucifora G. , Birn D.J. , Espinosa R. III , Erickson P. , Lebeau M.M. , Roulston D. , McKeithan T.W. , Drabkin H. , Rowley J.D.
Blood81:2728-2734(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM AML-1E);CHROMOSOMAL TRANSLOCATION WITH ETO
5.

"AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization."
Levanon D. , Negreanu V. , Bernstein Y. , Bar-Am I. , Avivi L. , Groner Y.
Genomics23:425-432(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM AML-1A)
tissue: Monocyte.
6.

"Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia."
Miyoshi H. , Ohira M. , Shimizu K. , Mitani K. , Hirai H. , Imai T. , Yokoyama K. , Soeda E. , Ohki M.
Nucleic Acids Res.23:2762-2769(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS AML-1B; AML-1A; AML-1G AND AML-1L)
7.

"The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation."
Meyers S. , Lenny N. , Hiebert S.W.
Mol. Cell. Biol.15:1974-1982(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM AML-1G)
tissue: B-cell.
8.

"A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells."
Zhang Y.-W. , Bae S.-C. , Huang G. , Fu Y.-X. , Lu J. , Ahn M.-Y. , Kanno Y. , Kanno T. , Ito Y.
Mol. Cell. Biol.17:4133-4145(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM AML-1L)
9.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM AML-1G)
12.

"Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia."
Mitani K. , Ogawa S. , Tanaka T. , Miyoshi H. , Kurokawa M. , Mano H. , Yazaki Y. , Ohki M. , Hirai H.
EMBO J.13:504-510(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-177;CHROMOSOMAL TRANSLOCATION WITH MECOM IN CHRONIC MYELOCYTIC LEUKEMIA
13.

"Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions."
Ghozi M.C. , Bernstein Y. , Negreanu V. , Levanon D. , Groner Y.
Proc. Natl. Acad. Sci. U.S.A.93:1935-1940(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-90 (ISOFORMS AML-1H AND AML-1I)
14.

"A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1."
Levanon D. , Bernstein Y. , Negreanu V. , Ghozi M.C. , Bar-Am I. , Aloya R. , Goldenberg D. , Lotem J. , Groner Y.
DNA Cell Biol.15:175-185(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 440-453;ALTERNATIVE SPLICING
tissue: Monocyte.
15.

"Sequencing and analysis of 960 kb between AML1 and CBR1 on chromosome 21q22.2."
Blechschmidt K. , Rump A. , Nordsiek G. , Drescher B. , Weber J. , Rosenthal A.
Submitted (1998-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19;ALTERNATIVE SPLICING (ISOFORM AML-1G)
16.

"Leukaemia/Drosophila homology."
Daga A. , Tighe J.E. , Calabi F.
Nature356:484-484(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIMILARITY TO RUNT
17.

"Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions."
Meyers S. , Downing J.R. , Hiebert S.W.
Mol. Cell. Biol.13:6336-6345(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENHANCER CORE BINDING SEQUENCE
18.

"ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function."
Bruhn L. , Munnerlyn A. , Grosschedl R.
Genes Dev.11:640-653(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ALYREF/THOC4
19.

"The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family."
Gamou T. , Kitamura E. , Hosoda F. , Shimuzu K. , Hayashi Y. , Nagase T. , Yokoyama Y. , Ohki M.
Blood91:4028-4037(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH CBFA2T3
20.

"Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors."
Levanon D. , Goldstein R.E. , Bernstein Y. , Tang H. , Goldenberg D. , Stifani S. , Paroush Z. , Groner Y.
Proc. Natl. Acad. Sci. U.S.A.95:11590-11595(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TLE1
21.

"Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias."
Mao S. , Frank R.C. , Zhang J. , Miyazaki Y. , Nimer S.D.
Mol. Cell. Biol.19:3635-3644(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ELF1; ELF2; ELF4 AND SPI1
22.

"Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein."
Kitabayashi I. , Aikawa Y. , Nguyen L.A. , Yokoyama A. , Ohki M.
EMBO J.20:7184-7196(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KAT6A;PHOSPHORYLATION
23.

"MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2."
Pelletier N. , Champagne N. , Stifani S. , Yang X.-J.
Oncogene21:2729-2740(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KAT6B;FUNCTION
24.

"SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo."
Chakraborty S. , Sinha K.K. , Senyuk V. , Nucifora G.
Oncogene22:5229-5237(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUV39H1;METHYLATION
25.

"Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene."
Cho J.-Y. , Akbarali Y. , Zerbini L.F. , Gu X. , Boltax J. , Wang Y. , Oettgen P. , Zhang D.-E. , Libermann T.A.
J. Biol. Chem.279:19512-19522(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ELF2
26.

"RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription."
Reed-Inderbitzin E. , Moreno-Miralles I. , Vanden-Eynden S.K. , Xie J. , Lutterbach B. , Durst-Goodwin K.L. , Luce K.S. , Irvin B.J. , Cleary M.L. , Brandt S.J. , Hiebert S.W.
Oncogene25:5777-5786(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUV39H1
27.

"Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction."
Fujimoto T. , Anderson K. , Jacobsen S.E. , Nishikawa S.I. , Nerlov C.
EMBO J.26:2361-2370(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MYELOID DIFFERENTIATION;INTERACTION WITH CDK6
28.

"LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22)."
Imagama S. , Abe A. , Suzuki M. , Hayakawa F. , Katsumi A. , Emi N. , Kiyoi H. , Naoe T.
Eur. J. Haematol.79:25-31(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH MACROD1
29.

"PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis."
Wee H.-J. , Voon D.C.-C. , Bae S.-C. , Ito Y.
Blood112:3777-3787(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-249; THR-273 AND SER-276 BY HIPK2;VARIANT GLN-174;MUTAGENESIS OF SER-67; LYS-83; GLY-108; SER-249; THR-273 AND SER-276
30.

"Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage."
Levy D. , Adamovich Y. , Reuven N. , Shaul Y.
Mol. Cell29:350-361(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH YAP1
31.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14 AND SER-21;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
32.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; SER-249; SER-266; SER-268 AND SER-276;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
33.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-24 AND LYS-43;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
34.

"Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta."
Warren A.J. , Bravo J. , Williams R.L. , Rabbitts T.H.
EMBO J.19:3004-3015(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 59-173 IN COMPLEX WITH CBFB
35.

"The leukemia-associated AML1 (Runx1) -- CBF beta complex functions as a DNA-induced molecular clamp."
Bravo J. , Li Z. , Speck N.A. , Warren A.J.
Nat. Struct. Biol.8:371-378(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 54-243 IN COMPLEX WITH CBFB AND DNA;MUTAGENESIS OF ARG-80; LYS-83; THR-84; ARG-135; ARG-139; ARG-142; LYS-167; THR-169; ASP-171; ARG-174 AND ARG-177
36.

"DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending."
Bartfeld D. , Shimon L. , Couture G.C. , Rabinovich D. , Frolow F. , Levanon D. , Groner Y. , Shakked Z.
Structure10:1395-1407(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 61-174 IN COMPLEX WITH DNA
37.

"Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain."
Nagata T. , Gupta V. , Sorce D. , Kim W.-Y. , Sali A. , Chait B.T. , Shigesada K. , Ito Y. , Werner M.H.
Nat. Struct. Biol.6:615-619(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 53-178;MUTAGENESIS OF ALA-107 AND GLY-108
38.

"The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains."
Berardi M.J. , Sun C. , Zehr M. , Abildgaard F. , Peng J. , Speck N.A. , Bushweller J.H.
Structure7:1247-1256(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 61-175 IN COMPLEX WITH DNA
39.

"The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding."
Baeckstroem S. , Wolf-Watz M. , Grundstroem C. , Haerd T. , Grundstroem T. , Sauer U.H.
J. Mol. Biol.322:259-272(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 46-185;CHLORIDE-BINDING
40.

"AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia."
Nucifora G. , Rowley J.D.
Blood86:1-14(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON AML1 TRANSLOCATIONS
41.

"Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells."
Nisson P.E. , Watkins P.C. , Sacchi N.
Cancer Genet. Cytogenet.63:81-88(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH MTG8/ETO IN AML-M2
42.

"Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction."
Kozu T. , Miyoshi H. , Shimizu K. , Maseki N. , Kaneko Y. , Asou H. , Kamada N. , Ohki M.
Blood82:1270-1276(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH MTG8/ETO IN AML-M2
43.

"The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript."
Miyoshi H. , Kozu T. , Shimizu K. , Enomoto K. , Maseki N. , Kaneko Y. , Kamada N. , Ohki M.
EMBO J.12:2715-2721(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH MTG8/ETO IN AML-M2
44.

"The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1."
Nucifora G. , Begy C.R. , Erickson P. , Drabkin H.A. , Rowley J.D.
Proc. Natl. Acad. Sci. U.S.A.90:7784-7788(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH EAP IN MYELODYSPLASIA
tissue: Peripheral blood.
45.

"Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2."
Tighe J.E. , Calabi F.
Blood84:2115-2121(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH MTG8/ETO IN AML-M2
46.

"The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion."
Romana S.P. , Mauchauffe M. , le Coniat M. , Chumakov I. , le Paslier D. , Berger R. , Bernard O.A.
Blood85:3662-3670(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH TEL IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
47.

"Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells."
Era T. , Asou N. , Kunisada T. , Yamasaki H. , Asou H. , Kamada N. , Nishikawa S. , Yamaguchi K. , Takatsuki K.
Genes Chromosomes Cancer13:25-33(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH MTG8/ETO IN AML-M2
48.

"Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia."
Golub T.R. , Barker G.F. , Bohlander S.K. , Hiebert S.W. , Ward D.C. , Bray-Ward P. , Morgan E. , Raimondi S.C. , Rowley J.D. , Gilliland D.G.
Proc. Natl. Acad. Sci. U.S.A.92:4917-4921(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH TEL IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
49.

"Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia."
Song W.-J. , Sullivan M.G. , Legare R.D. , Hutchings S. , Tan X. , Kufrin D. , Ratajczak J. , Resende I.C. , Haworth C. , Hock R. , Loh M. , Felix C. , Roy D.-C. , Busque L. , Kurnit D. , Willman C. , Gewirtz A.M. , Speck N.A. , more...
Nat. Genet.23:166-175(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FPDMM GLN-139 AND GLN-174
50.

"Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes."
Gelsi-Boyer V. , Trouplin V. , Adelaide J. , Aceto N. , Remy V. , Pinson S. , Houdayer C. , Arnoulet C. , Sainty D. , Bentires-Alj M. , Olschwang S. , Vey N. , Mozziconacci M.-J. , Birnbaum D. , Chaffanet M.
BMC Cancer8:299-299(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL REARRANGEMENT

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